Potential biomedical applications of non-dissipative acoustic radiation force

Sarvazyan, Armen; Tsyuryupa, Sergey

doi:10.1121/2.0000337

Cited by 4 publications

(8 citation statements)

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“…The effects of this D-ARF are most pronounced in sonication of the medium by short ultrasonic pulses with durations on the order of microseconds. The D-ARF is generated locally at the boundaries between tissue structures and contribution of D-ARF could be pronounced in the case of short excitation pulses in the microsecong range, as it follows from available experimental data [78]. At longer ultrasound exposures in the range of milliseconds and longer, which are typically used in many acoustic imaging technologies, the contribution of D-ARF becomes negligible relative to A-ARF because of great absorption of ultrasound in biological tissues.…”

Section: In P T X C −mentioning

confidence: 92%

“…The ARF based on mechanism (D), let it be called D-ARF, results from the variation in acoustic energy density due to gradients of compressional wave speeds and mass densities in the medium [31,78]. Similar to B-ARF, it also is not related to the dissipation of energy.…”

Section: Mechanism Dmentioning

confidence: 99%

“…where p=p IN is as defined above. The resulting force can have different signs, which will lead to either pushing the boundary from the ultrasonic source or pulling toward it [78]. This possibility of changing the direction of force was first demonstrated in the experiment of Hertz and Mende [7].…”

Section: In P T X C −mentioning

confidence: 99%

“…But with decreasing the pulse duration, the contribution of A-ARF becomes negligible relative to B-ARF and D-ARF. The contribution of B-ARF relative to D-ARF, analyzed in [78] using theory of D-ARF developed by R. Beyer [79] is shown to be on the order of a few percent. For example, it is estimated that the contributions of B-ARF relative to the D-ARF acting on the interface between blood and liver and between blood and brain are 1.7% and 4.2% correspondingly.…”

Section: In P T X C −mentioning

confidence: 99%

See 3 more Smart Citations

Acoustic Radiation Force: A Review of Four Mechanisms for Biomedical Applications

Sarvazyan

Руденко

Fatemi

2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Radiation force is a universal phenomenon in any wave motion where the wave energy produces a static or transient force on the propagation medium. The theory of acoustic radiation force (ARF) dates back to the early 19th century. In recent years, there has been an increasing interest in the biomedical applications of ARF. Following a brief history of acoustic radiation force, this paper describes a concise theory of ARF under four physical mechanisms of radiation force generation in tissue-like media. These mechanisms are primarily based on the dissipation of acoustic energy of propagating waves, the reflection of the incident wave, gradients of the compressional wave speeds, and the spatial variations of energy density in standing acoustic waves.Examples describing some of the practical applications of ARF under each mechanism are presented. This paper concludes with a discussion on selected ideas for potential future applications of ARF in biomedicine.

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Section: In P T X C −mentioning

confidence: 92%

Section: Mechanism Dmentioning

confidence: 99%

Section: In P T X C −mentioning

confidence: 99%

Section: In P T X C −mentioning

confidence: 99%

See 2 more Smart Citations

Acoustic Radiation Force: A Review of Four Mechanisms for Biomedical Applications

Sarvazyan

Руденко

Fatemi

2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…It is possible to deliver force in a noncontact manner using ARF [ 90 ], and ARF has been considered as one possible mechanism in nanostructure-based theranostics [ 111 ]. The biomedical applications of ARF have been covered in several reviews by Sarvazyan et al [ 91 , 101 , 112 ] and Urban et al [ 113 ]. The schematic illustration of this mechanism is presented in Figure 2 .…”

Section: Reviewmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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Acoustic radiation force and motion of a free cylinder in a viscous fluid with a boundary defined by a plane wave incident at an arbitrary angle

Zhang

Gong

et al. 2020

Journal of Applied Physics

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The acoustic radiation force (ARF) is derived for a free cylinder immersed in a viscous fluid with a boundary defined by a plane wave incident at an arbitrary angle. Trajectories of a free rigid cylinder under the action of ARF are also investigated. Various aspects affecting the ARFs and trajectories of a free rigid cylinder, such as fluid viscosity, the incident angle of the plane wave, the density ratio of the fluid to particle, the particle radius, and boundary, are addressed in numerical simulations. Results show that ARFs are positive or negative depending on the various factors considered in this work. Moreover, the amplitude of the total ARF on a free cylinder in a bounded viscous fluid defined by a plane wave incident at a certain angle may decrease with increasing viscosity, which is significantly different from the case of a fixed cylinder immersed in a boundless viscous fluid. Furthermore, the trajectory of the particle changing with different conditions is investigated. We can predict and regulate the particle trajectory by selecting relevant parameters. The finite element method is implemented to validate the theoretical results. The finite element results and theoretical results are in good agreement. This work helps better understand the underlying mechanism of the particle manipulation using ARF.

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Potential biomedical applications of non-dissipative acoustic radiation force

Cited by 4 publications

References 0 publications

Acoustic Radiation Force: A Review of Four Mechanisms for Biomedical Applications

Acoustic Radiation Force: A Review of Four Mechanisms for Biomedical Applications

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Acoustic radiation force and motion of a free cylinder in a viscous fluid with a boundary defined by a plane wave incident at an arbitrary angle

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