Potential Biomarkers of Preeclampsia: Inverse Correlation between Hydrogen Peroxide and Nitric Oxide Early in Maternal Circulation and at Term in Placenta of Women with Preeclampsia

Aris, Aziz; Benali, Saad; Ouellet, Annie; Moutquin, Jean‐Marie; Leblanc, Samuel

doi:10.1016/j.placenta.2009.01.003

Cited by 70 publications

(44 citation statements)

References 37 publications

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“…Preeclampsia is a major cause of maternal deaths of obstetric cause and is responsible for high morbidity and fetal mortality (Aris et al, 2009). Preeclampsia is characterized by de novo hypertension (two blood pressure measurements ≥ 140/90 mmHg) and proteinuria (> 300 mg/24 h) that develops after 20 weeks of gestation in a formerly normotensive woman (Health Secretary, 2007).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

Sandoval-Carrillo¹,

Aguilar-Durán²,

Vazquez-Alaniz³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of preeclampsia. This case-control study involved 112 preeclamptic and 233 normoevolutive pregnant women. The null polymorphisms were 2161 GSTT1/GSTM1 null polymorphisms and preeclampsia ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 2160-2165 (2014) genotyped by multiplex polymerase chain reaction (PCR). Our results showed an increased risk of preeclampsia in patients with the GSTT1 null genotype [odds ratio (OR) = 2.21; 95% confidence interval (CI) = 1.14-4.27; P = 0.018]. Our data further showed that a combination of deletion genotypes of the GSTM1 and GSTT1 genes conferred an even higher risk of preeclampsia (OR = 4.56, 95%CI = 1.59-13.09; P = 0.005). Our results provide the first evidence suggesting that a GSTT1 null polymorphism might be associated with preeclampsia in the Mexican mestizo population, and that this risk increases with the combination of both GSTT1 and GSTM1 null polymorphisms.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

Sandoval-Carrillo¹,

Aguilar-Durán²,

Vazquez-Alaniz³

et al. 2014

Genet. Mol. Res.

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“…HHcy was signifi cantly positively correlated with ADMA, and both of them were signifi cantly negatively correlated with NO. Several studies were interested in assessing the levels of NO in pre-eclampsia (Aris et al 2009). However, these studies were contradictory, since some have shown increased levels of NO in maternal circulation (Bhatnagar et al 2007;Vural 2002) and placenta (Shaamash et al 2000), while others found decreased levels in maternal serum (Sandrim et al 2008) and placenta (Schonfelder et al 2004) or even normal levels (Orange et al 2003).…”

Section: Discussionmentioning

confidence: 99%

The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia

Demir

Paşa

et al. 2012

Journal of Obstetrics and Gynaecology

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Nitric oxide (NO) contributes to vasodilatation that is observed during normal pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has been linked to endothelial dysfunction. Maternal ADMA has been reported to be higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The aim of this presented study is to evaluate the alterations of plasma homocysteine, ADMA and NO levels in mild pre-eclampsia. A total of 40 pre-eclamptic women and 40 healthy controls were included into the study. Mean systolic and diastolic blood pressure, mean serum homocysteine and ADMA levels were significantly higher and NO level was lower in patients. Serum homocysteine, ADMA and NO levels found to be correlated among them and with blood pressure. In conclusion, we found that homocysteine and ADMA levels were increased and NO levels decreased in pre-eclampsia.

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“…Aris et al [81] found a significant inverse correlation between increased levels of H 2 O 2 and decreased levels of NO early in maternal circulation and at term, in the placenta of women with PE. The Chappell et al [82] case-control study assessed antioxidant status, oxidative stress, placental and endothelial function, and serum lipid concentrations in 160 women.…”

Section: Cellular Inflammatory Markersmentioning

confidence: 98%

Markers of preeclampsia and the relationship to cardiovascular disease: review of the twenty-first century literature

Gastrich

Faro

Rosen

2010

The Journal of Maternal-Fetal & Neonatal Medicine

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Potential Biomarkers of Preeclampsia: Inverse Correlation between Hydrogen Peroxide and Nitric Oxide Early in Maternal Circulation and at Term in Placenta of Women with Preeclampsia

Cited by 70 publications

References 37 publications

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

The role of homocysteine, asymmetric dimethylarginine and nitric oxide in pre-eclampsia

Markers of preeclampsia and the relationship to cardiovascular disease: review of the twenty-first century literature

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