Potential bioactive phenolics of Macedonian Sideritis species used for medicinal “Mountain Tea”

Petreska, Jasmina; Стефова, Марина; Ferreres, Federico; Moreno, Diego A.; Tomás‐Barberán, Francisco A; Stefkov, Gjoshe; Kulevanova, S.; Gil‐Izquierdo, Ángel

doi:10.1016/j.foodchem.2010.08.019

Cited by 63 publications

(66 citation statements)

References 28 publications

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“…In a similar way, the compound eluting in fraction 10 ( (Karioti, Bolognesi, Vincieri, & Bilia, 2010;Petreska et al, 2011) Isoscutellarein acetyl derivatives were also found in PEEL (fractions 5, 7, 9 and 11), as confirmed by the initial loss of 42 Da in their MS 2 spectra. From those, the isomeric compounds (MW 652 Da) which eluted in the first three fractions were the acetyl derivatives of isoscutellarein-O-allosyl(1→ 2)glucoside (compound of fraction 4) and of 4′-O-methylisoscutellarein-7-O-allosyl(1→ 2)glucoside (compound of fraction 10).…”

Section: Isoscutellarein Derivativessupporting

confidence: 62%

“…Moreover, the product ion [M−H−180] − at m/z 429 indicated the 1 → 2 glycosylation between the sugars (Ferreres et al, 2004;Petreska et al, 2011). Note that this compound has been previously described to occur in genus Stachys and Sideritis, both belonging to the same subfamily (Lamioideae) as Lamium (Ferreres et al, 2004;Petreska et al, 2011;Tomás-Barberán, Francisco, Gil, Ferreres, & Tomás-Lorente, 1992).…”

Section: Isoscutellarein Derivativesmentioning

confidence: 79%

“…The MS 2 spectrum of the major acetylated isomer of isoscutellarein-O-allosyl(1 → 2)glucoside, eluted in fraction 9 ([M−H] − ion at m/z 651), showed a base peak at m/z 285 ([M−H−324−42] − ), which is indicative for O-acetylglycosylation onto the phenolic hydroxyl groups (Petreska et al, 2011). Moreover, the intermediate ion [M-H-42-180] − at m/z 429 was indicative of an acetyl group on the external sugar (Karioti et al, 2010).…”

Section: Isoscutellarein Derivativesmentioning

confidence: 99%

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Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L. album L. is far from being understood. In this study, a purified ethanolic extract (PEEL) was prepared and further analyzed by high performance liquid chromatography and electrospray mass spectrometry. Overall, verbascoside accounted for approximately half of the phenolic content of the extract, but this also contained other bioactive phenolic compounds herein detected for the first time in the genus, namely isoscutellarein derivatives. The latter included isoscutellarein-7-O-allosyl(1 →2)glucoside, its O-methyl derivative, three acetyl derivatives of isoscutellarein-Oallosyl glucoside and one acetylated form of O-methylisoscutellarein-7-O-allosyl(1 →2)glucoside. From those, the main isoscutellarein derivative was assigned to isoscutellarein-7-O-(6-O-acetyl-β-allosyl)(1→2)-β-glucoside, as confirmed by NMR. Altogether, isoscutellarein derivatives accounted for almost 30% of PEEL phenolics. Since verbascoside and isoscutellarein derivatives are main components of L. album L. ethanolic extract, their possible association to the health benefits of the plant is discussed.

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Section: Isoscutellarein Derivativessupporting

confidence: 62%

Section: Isoscutellarein Derivativesmentioning

confidence: 79%

Section: Isoscutellarein Derivativesmentioning

confidence: 99%

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Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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“…Other fragmentation corresponding with cinnamic acids, m/z 179 and 161, was also observed. The compound was identified as echinacoside by compression to compound previously reported (Petreska et al, 2011).…”

Section: Resultsmentioning

confidence: 87%

Phytochemical characterization of phenolics by LC-MS/MS and biological evaluation of Ajuga orientalis from Turkey

Göğer

Köse

Göğer

et al. 2015

Bangladesh J Pharmacol

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The aim of this study was to reveal the phytochemical constituents, antioxidant and antimicrobial activity of Ajuga orientalis. According to the antimicrobial results, the methanol extract of A. orientalis showed a MIC value of 312.5 µg/mL against the tested pathogenic bacterial strains. Anticandidal activity of extract was found as 156.3 µg/mL both against Candida albicans and C. parapsilosis strains. Whereas the extract was more effective against C. tropicalis with the MIC value of 78.1 µg/mL. The in vitro DPPH radical scavenging activity of the extract was determined as IC50=0.4 ± 0.02 mg/mL whereas the standard BHT IC50 was 0.01 ± 0.00 mg/mL. Trolox Equivalent Antioxidant Capacity (TEAC) of extract was determined 1.3 mM TEAC, while BHT, 1.9 mM TEAC.

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“…LC-UV-MS plays an important role in the screening of phenols and flavonoids. In most cases, ESI-IT-MS n spectral information in conjunction with UV spectra allows rapid identification [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84]. The application of TOF-MS in structural elucidation of natural products is of ever increasing interest because TOF mass analyzer with high resolving power can provide the accurate mass measurement and full scan spectral sensitivity [85].…”

Section: Phenols and Flavonoidsmentioning

confidence: 99%