Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Andrade, Thaís Montenegro de; Melo, Ademar Soares; Dias, Rui Guilherme Cardoso; Varela, Everton Luís Pompeu; Oliveira, Fábio Rodrigues de; Vieira, José Luís Fernandes; Andrade, Milene Aparecida; Baetas, Ana Cristina; Monteiro, Marta Chagas; Maia, Cristiane do Socorro Ferraz

doi:10.1016/j.jep.2012.07.020

Cited by 24 publications

(23 citation statements)

References 26 publications

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“…Moreover, lesions can lead to cell inactivation, as well as mutagenic potential (Friedberg et al, 2006), justifying the need for further such studies in other experimental models, such as bacteria and eukaryotic cells. In addition, some studies suggest that various extracts or compounds of this species exhibit antioxidant or pro-oxidant activity (Carlini, 2003;Andrade et al, 2012). In this work, the antigenotoxic effect was influenced by plant origin, suggesting, in turn, the influence of some genetic variation.…”

Section: Discussionmentioning

confidence: 54%

“…Some studies have reported on the pro-oxidant effects of this species in different experimental models (Salim, 2011;Andrade et al, 2012). Using a sea urchin model, a moderate genotoxic activity, based on cytogenetic changes, was reported (Hoyos et al, 1992), but to our knowledge, this is the first study on the effect of extracts of P. alliacea on the DNA molecule.…”

Section: Discussionmentioning

confidence: 85%

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License (Ponte et al, 1996), acaricide (Johnson et al, 1997), antibacterial (Szczepan et al, 1972;Williams et al, 2003), antifungal (Benevides et al, 2001), and treatment for bovine viral diarrhea virus (BVDV) (Ruffa et al, 2002). Many of these effects may result from a cytotoxic mechanism also described for this species as the inhibition of antioxidant status in vitro and in vivo, featuring pro-oxidant effects in a concentrationdependent manner (Andrade et al, 2012). On the other hand, components of the extracts have shown a well-defined antioxidant activity (Delle-Monache et al, 1996;Okada et al, 2008), as well as immunomodulatory (Quadros et al, 1999) and neuropharmacological activities (Cifuentes et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

N¹,

Mansur²,

Dantas³

et al. 2014

J. Med. Plants Res.

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Petiveria alliacea L. is a native herbaceous species from the Amazon region traditionally used in folk medicine for its various pharmacological activities. This study aimed to perform a comparative assessment of genotoxic and antigenotoxic potential of field-and in vitro-grown plants. Specimens from different populations from Rio de Janeiro State were used as donor plants for in vitro culture on Murashige and Skoog (MS) medium. Aqueous extracts from field and in vitro plants were evaluated by analyzing their effect on the integrity of pUC 9.1 plasmid. DNA genotoxic potential was assessed after treatment of plasmid DNA with increasing concentrations of aqueous extracts (1.0, 5.0 t o 10.0 mg/ml) from the populations studied and the in vitro plants originated from them. The electrophoretic analysis showed changes in the structural conformation of plasmid DNA, indicating the occurrence of single-and double-strand breaks caused by the extracts, demonstrating the genotoxic potential at higher concentrations. The antigenotoxic potential was assessed based on plasmid protection induced by the extracts after DNA treatment with stannous chloride. Thus, data also pointed to a antigenotoxic effect of extracts against oxidative damage. In addition, the intensity of the effect of extracts on plasmid DNA varied according to origin of plants.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

N¹,

Mansur²,

Dantas³

et al. 2014

J. Med. Plants Res.

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“…Petiveria alliacea is an important Amazonian herb with (Andrade et al, 2012;Silva et al, 2015). Although previous studies have demonstrated that P. alliacea induces genotoxic hazards in low concentrations, there is a lack of information about the effects of high concentrations of ethanolic preparations in both in vitro and in vivo models.…”

Section: Discussionmentioning

confidence: 99%

“…The hydroalcoholic extract was choosen because previous studies of our group have demonstrated its potential effects on central nervous system when comparing with traditionally preparations (Andrade et al, 2012;Silva et al, 2015). Crude EHPa was prepared through the maceration method.…”

Section: Extract Preparationmentioning

confidence: 99%

In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

Silva¹,

Oliveira²,

PaixÃ£o³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract. Genotoxicity was evaluated using an in vitro comet assay in human lymphocytes (50, 100, and 250 mg/ml) and an in vivo micronucleus assay in mice orally treated with the extract (50, 100, and 250 mg/kg b.w., p.o.). The phytochemical screening identified the metabolites reducing sugars, alkaloids and saponins. TLC analyses identified organosulfur compounds in EHPa. Comet assay data showed that EHPa induced exacerbated DNA damage at 100 mg/ml treatments (EHPa 100 mg/ml:

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Plants of the Phytolaccaceae family with antimicrobial activity: A systematic review

Sydor

Ramos‐Milaré

Pereira

et al. 2022

Phytotherapy Research

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Phytolaccaceae is a plant family of the order Caryophyllales, which includes species used in traditional medicine to treat diseases. The purpose of this study was to investigate Phytolaccaceae family plants with potential antimicrobial action, through a systematic review. The study was conducted following the criteria of PRISMA protocol. The search was performed in the electronic databases PubMed, Web of Science, Scopus, and LILACS, in March 2021. The search strategy used free descriptors and terms, limiting articles to the English language, regardless of publication year. The risk of bias and the quality of publications were based on the CONSORT checklist, modified for in vitro studies and SYRCLE’s RoB tool for in vivo study. Five independent judges performed quality assessments of publications and risk of bias analysis. Ninety‐five publications were retrieved from the databases and, after screening and eligibility criteria, 22 articles remained, from 1998 to 2019. In the selected studies, the plants were obtained from eight countries. In vivo and in vitro studies of extracts from the Phytolaccaceae family plants, evaluating antibacterial (8 publications), antifungal (8), anti‐Trypanosoma (2), anti‐Leishmania (2), antiviral (1), and antiamoebic (1) activities, are included. The plant species identified belong to genera Petiveria, Phytolacca, Gallesia, Trichostigma, and Seguieria. The risk of bias in the 22 publications both in vitro and in vitro was suboptimal. The evidence obtained showed that the Phytolaccaceae family, a source of plants with antimicrobial action, can serve as a basis for the creation of new herbal medicines, expanding the possibility of treatment for infectious diseases and stimulating their preservation and biodiversity. However, more high‐quality studies are needed to establish the clinical efficacy of the plant.

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Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Cited by 24 publications

References 26 publications

Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

Effect of extracts from field and in vitro plants of Petiveria alliacea L. on plasmidial DNA

In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

Plants of the Phytolaccaceae family with antimicrobial activity: A systematic review

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