In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

Silva, JoÃ£o Paulo Bastos; Oliveira, FÃ¡bio Rodrigues de; PaixÃ£o, Thiago Portal da; Malcher, NÃ­vea Silva; Santos, PatrÃ­cia Carara dos; Baetas, Ana Cristina; Batitucci, Maria do Carmo Pimentel; Monteiro, Marta Chagas; Andrade, Marcieni AtaÃ­de de

doi:10.5897/ajpp2016.4581

Afr. J. Pharm. Pharmacol.

2016

DOI: 10.5897/ajpp2016.4581

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In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

JoÃ£o Paulo Bastos Silva¹,

FÃ¡bio Rodrigues de Oliveira²,

Thiago Portal da PaixÃ£o³

et al.

Abstract: Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract. Genotoxicity was evaluated using an in vitro comet assay in human lymphocytes (50, 100, and 250 … Show more

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Cited by 3 publications

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Flavonoid quantitative HPLC-DAD analysis of Petiveria alliacea

Henrique,

Pereira,

Fernandes Afonso

et al. 2024

Journal of Liquid Chromatography & Related Technologies

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Flavonoid quantitative HPLC-DAD analysis of Petiveria alliacea

Henrique,

Pereira,

Fernandes Afonso

et al. 2024

Journal of Liquid Chromatography & Related Technologies

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Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis

Choi,

Im,

Choi

et al. 2024

Front. Pharmacol.

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BackgroundThe use of herbal medicines (HMs) for the treatment of hypertension (HTN) is increasing globally, but research on the potential adverse effects and safety of HMs in HTN patients is limited. Therefore, this systematic review and meta-analysis aim to determine the global prevalence of HM usage among HTN patients and assess the safety of identified herbs based on current scientific evidence.MethodsThe PubMed/MEDLINE, EMBASE (Ovid), and Cumulated Index to Nursing and Allied Health Literature (CINAHL) databases were searched for cross-sectional studies on the use of HM among HTN patients. Our review includes studies published in English up to the year 2023. After extracting and appraising the data from the studies, a meta-analysis was conducted using the Stata version 16.0 to estimate the pooled prevalence of HM use in patients with HTN (PROSPERO: CRD42023405537). The safety classification of the identified HM was done based on the existing scientific literature.ResultsThis study analyzed 37 cross-sectional studies from 21 countries and found that 37.8% of HTN patients used HM to manage their health. The prevalence of HM use varied significantly based on publication year and geographical region. Among the 71 identified herbs, Allium sativum L., Hibiscus sabdariffa L., and Olea europaea L. were the most commonly used. However, four herbs were identified as contraindicated, 50 herbs required caution, and only 11 herbs were considered safe for use.ConclusionThe study highlights the potential risks of toxicities and adverse effects associated with HM use in the treatment of HTN. Ensuring patient safety involves using safe HMs in appropriate doses and avoiding contraindicated HMs. Future research should focus on identifying commonly used herbs, especially in resource-limited countries with poor HTN management, and additional clinical research is required to assess the toxicity and safety of commonly used HMs.

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Cytotoxicity of Extracts from Petiveria alliacea Leaves on Yeast

Cal

Araújo

Nunes

et al. 2022

Plants

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Petiveria alliacea L. is a plant used in traditional medicine harboring pharmacological properties with anti-inflammatory, antinociceptive, hypoglycemiant and anesthetic activities. This study assessed the potential cytotoxic, genotoxic and mutagenic effects of ethanolic extract of P. alliacea on Saccharomyces cerevisiae strains. S. cerevisiae FF18733 (wild type) and CD138 (ogg1) strains were exposed to fractioned ethanolic extracts of P. alliacea in different concentrations. Three experimental assays were performed: cellular inactivation, mutagenesis (canavanine resistance system) and loss of mitochondrial function (petites colonies). The chemical analyses revealed a rich extract with phenolic compounds such as protocatechuic acid, cinnamic and catechin epicatechin. A decreased cell viability in wild-type and ogg1 strains was demonstrated. All fractions of the extract exerted a mutagenic effect on the ogg1 strain. Only ethyl acetate and n-butanol fractions increased the rate of petites colonies in the ogg1 strain, but not in the wild-type strain. The results indicate that fractions of mid-polarity of the ethanolic extract, at the studied concentrations, can induce mutagenicity mediated by oxidative lesions in the mitochondrial and genomic genomes of the ogg1-deficient S. cerevisiae strain. These findings indicate that the lesions caused by the fractions of P. alliacea ethanolic extract can be mediated by reactive oxygen species and can reach multiple molecular targets to exert their toxicity.

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In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

Cited by 3 publications

References 48 publications

Flavonoid quantitative HPLC-DAD analysis of Petiveria alliacea

Flavonoid quantitative HPLC-DAD analysis of Petiveria alliacea

Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis

Cytotoxicity of Extracts from Petiveria alliacea Leaves on Yeast

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