Potential association of long noncoding RNA HA117 with tetralogy of Fallot

Abstract

Tetralogy of Fallot (TOF) is a congenital heart disease characterized by abnormal cardiomyocyte differentiation in the right ventricular outflow tract (RVOT), and HA117 is a novel long noncoding RNA (lncRNA) with anti-differentiation roles.To investigate the potential association of HA117 with TOF, we collected 84 RVOT tissues from patients with TOF. We determined the expression of HA117 in RVOT samples from TOF patients and collected clinical data to conduct a cross-sectional and short-term follow-up study.McGoon ratio, Nakata index, and left ventricular end-diastolic volume index (LVEDVI) were negatively correlated with the expression of HA117 based on subgroup analysis, correlation analysis and logistic regression analysis. Additionally, cardiopulmonary bypass (CPB) time and ICU stay were longer in patients with higher expression of HA117 than in patients with lower expression of HA117. Furthermore, percentage improvement in SPO2 was significantly reduced in patients with increased HA117 expression at 6 months after surgery.Our results suggested that the increased expression of the novel lncRNA HA117 is a risk factor for unfavorable McGoon ratio, Nakata index and LVEDVI in TOF patients. Additionally, an increased expression of HA117 might lead to adverse short-term outcomes in TOF patients.

Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System

“…LncRNA HA117, which is known to suppress cardiomyocyte differentiation, is associated with diminished cardiac function in children with Tetralogy of Fallot (TOF). TOF is a common congenital heart defect usually characterized with a narrowed right ventricular outflow tract (RVOT) due to abnormal cardiomyocyte differentiation [ 57 ]. Although the functional contribution of HA117 to the pathogenesis of TOF is yet to be elucidated, expression of this lncRNA may prove to be a useful prognostic indicator [ 57 ].…”

Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

“…Tetralogy of Fallot (TOF) is one of the most common congenital heart diseases, characterized by defective ventricular septum and irregular cardiomyocyte differentiation, leading to the narrowing of right ventricular outflow tract (RVOT). Wang et al reported that increased cardiac tissue (RVOT) levels of HA117, a lncRNA known to have anti-differentiation function, is associated with poorer McGoon ratio, Nakata index, and left ventricular end-diastolic volume index (LVEDVI) in patients with TOF [116]. In addition, patients with higher levels of HA117 had longer cardiopulmonary bypass (CPB) time, ICU stay and poorer percentage improvement in SpO2 at 6 months after surgery.…”

“…In addition, patients with higher levels of HA117 had longer cardiopulmonary bypass (CPB) time, ICU stay and poorer percentage improvement in SpO2 at 6 months after surgery. Although the functional contribution of HA117 to the pathogenesis of TOF remains unknown, Wang et al proposed that HA117 could serve as a prognostic biomarker for TOF [116]. Table 6 summarizes lncRNAs that are involved in the development of cardiovascular system.…”

The Role of Non-Coding RNA in Congenital Heart Diseases

“…However, evidence of their functional implications is still lacking. On the other hand, a large dataset has provided evidence of the involvement of multiple deregulated microRNAs in distinct conditions of TOF, including pediatric [14,57,58,59,60,61] and corrected adult patients [62,63].…”