Potential association of COVID-19 and ABO blood group: An Indian study

Garg, Iti; Srivastava, Swati; Dogra, Vikas; Bargotya, Mona; Bhattar, Sonali; Gupta, Utkarsh; Jain, S. K.; Hussain, Javid; Hembrom, Anju Angelina; Ghosh, Nilabja; Kumar, Vinay; Kumar, Bhuvnesh; Varshney, Rajeev K.; Ganju, Lilly

doi:10.1016/j.micpath.2021.105008

Cited by 13 publications

(18 citation statements)

References 32 publications

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“…Dentali et al confirmed the link between ABO blood groups and thrombosis risk in general, in which individuals with non-O blood groups were more likely to experience thrombotic episodes of venous or arterial origin [ 6 ]. Another study found an association between ABO blood groups and viral infections such as rotavirus, norovirus (NoV), dengue virus, Norwalk virus, and hepatitis B virus [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Bokhary¹,

Bokhary²,

Seadawi³

et al. 2022

Cureus

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The primary objective of this study was to explore whether coronavirus disease 2019 severity and outcomes varied between different ABO blood groups. This retrospective study included 363 COVID-19 confirmed patients who had their blood group recorded in the hospital medical records, from March to June 2020. Data representing demographics, clinical features, vital signs, laboratory findings, and COVID-19 outcomes were collected. Multivariate logistic regression was used for analysis and the results were adjusted for sociodemographic, clinical, and laboratory variables. The patients' mean age was 50 ± 17.8 years. Of the 363 patients, 30% were blood group A, 22.3% were blood group B, 8.8% were blood group AB, and 38.8% were blood group O. Bivariate analysis showed that patients with blood group AB were more likely to be free of any medical disease (65.6%) compared to other blood groups (p = 0.007). Fever was the most common presenting complaint (66.7%), and it did not significantly vary with changes in ABO blood groups (p = 0.230). Regarding laboratory characteristics, only C-reactive protein (CRP) levels were significantly associated with the blood groups, with high levels seen in blood groups A, B, and O (p = 0.036). In multivariate analysis, variations in emergency department (ED) disposition, requirement of intensive care unit care, and requirement of mechanical ventilation were not statistically significant among the different ABO blood groups. Furthermore, no correlation was found between hospital death and the different ABO blood groups. In conclusion, COVID-19 is most prevalent among patients with blood group O and least prevalent among those with blood group AB. No particular blood group had worse COVID-19 disease severity and outcomes than other blood groups. Therefore, we believe that ABO blood grouping should not be used as a major assessment tool for COVID-19 disease severity and outcome, and other known risk factors should be investigated.

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Section: Introductionmentioning

confidence: 99%

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Bokhary¹,

Bokhary²,

Seadawi³

et al. 2022

Cureus

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“…The present study collects clinical profiles of 383 COVID-19 patients from India. Out of these patients, 251 were males and 132 were females [ 23 ]. Thrombotic parameters of 70 patients were recorded and correlated with the severity of infection and mortality.…”

Section: Introductionmentioning

confidence: 99%

Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients

et al. 2022

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Introduction: Coronavirus disease 2019 (COVID-19) is a novel viral disease that spread as a global pandemic in 2020 by infecting millions of people across the world. Its clinical prognosis is dependent on various coagulatory parameters since thrombotic events are frequently associated with infection severity. Methods: A total of 383 COVID-19 patients enrolled in Rajiv Gandhi Super Specialty Hospital, Delhi, India, were included in the present retrospective study. Patients were divided into three categories, severe (n = 141), moderate (n = 138), and mild (n = 104) based on infection severity. Various thrombotic parameters and anticoagulant levels were measured in 70 patients and further analyzed. Results: Coagulopathy is seen in COVID-19 patients (n = 70) with a significant increase in fibrinogen, D-dimer levels, and prothrombin time in patients with severe and moderate disease compared to patients with a mild infection. Approximately, 70% of patients with severe and moderate disease demonstrated fibrinogen levels higher than the standard reference range. 60.41% of patients with severe disease showed significantly higher D-dimer levels. Thrombotic parameters were notably elevated in the nonsurvivors group compared to COVID-19 survivors. Nearly, 91% of patients with severe infection had anticoagulant protein S levels below the reference range. Conclusion: COVID-19 infection severely impacts the blood coagulation cascade, which might lead to the manifestation of severe symptoms and increased mortality in patients.

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“…During the current pandemic, several studies have investigated the association of blood groups and COVID-19 [ 13–18 ]. Some studies suggested that patients with blood group A are more susceptible to severe infection, but there are other controversial results [ 19–24 ]. More studies are needed to confirm the association between blood grouping and COVID-19 susceptibility and severity.…”

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confidence: 99%

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

et al. 2021

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Aim: Many factors have been speculated to explain the COVID-19 complex clinical phenotype. Due to the inconsistent data published on blood groups and COVID-19, we conducted a study on Iranian patients to further assess this association. Materials & methods: This retrospective study was conducted on data collected from confirmed COVID-19 hospitalized patients during March and December 2020 in a referral hospital for COVID-19, 5 Azar Hospital, Gorgan, north of Iran. A total of 1554 confirmed COVID-19 cases were enrolled in the study with blood group (ABO and Rh), demographic, and clinical data available. Results: Of 1554 patients, 1267 and 287 cases had recovered and deceased (due to COVID-19) outcomes, respectively. Most of the cases had O+ (29.6%), the least number had AB- (0.5%), and most of the deceased cases had O+ blood types (31.4%). Logistic regression analysis revealed that groups A- and B- had higher and groups B+, AB+, O+ and O- had lower odds of death than the A+ group. Conclusion: This study indicates that blood types may be related to the clinical outcome of COVID-19. Further studies with a large cohort for multiple people are required to validate this association.

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Potential association of COVID-19 and ABO blood group: An Indian study

Cited by 13 publications

References 32 publications

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Implications of COVID-19 on Thrombotic Profile of Severely Affected Patients

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

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