Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis

Keikha, Masoud

doi:10.1016/j.nmni.2022.100980

Cited by 6 publications

(1 citation statement)

References 88 publications

(81 reference statements)

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“…), etc., which revealed that some of the most common autoantigen targets in COVID-19-associated coagulopathies, such as CL, PF4 and β2GP, have significant mimics with these bacteria but do not have significant mimics with SARS-CoV-2 and especially its spike protein [ 40 ] (summarized in Figure 1 ). Since some bacterial infections, especially GAS , Staphylococci, Klebsiella and Clostridia , are themselves associated with increased risks of coagulopathies [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ], these results suggested that preceding or concomitant bacterial co-infections may support the induction of a variety of COVID-19 autoimmune coagulopathies through anamnestic secondary cross-reactivity or bystander activation of complementary autoimmune mechanisms to those activated by SARS-CoV-2. Conversely, if a pre- or co-existing bacterial infection were necessary to induce autoimmune coagulopathies, then the absence of such infections among the vast majority of vaccinees might explain the extremely infrequent occurrence of vaccine-induced thrombotic events [ 62 , 63 ].…”

Section: Introductionmentioning

confidence: 99%

Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 Coagulopathies

Root‐Bernstein

Huber

Ziehl

2022

IJMS

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COVID-19 patients often develop coagulopathies including microclotting, thrombotic strokes or thrombocytopenia. Autoantibodies are present against blood-related proteins including cardiolipin (CL), serum albumin (SA), platelet factor 4 (PF4), beta 2 glycoprotein 1 (β2GPI), phosphodiesterases (PDE), and coagulation factors such as Factor II, IX, X and von Willebrand factor (vWF). Different combinations of autoantibodies associate with different coagulopathies. Previous research revealed similarities between proteins with blood clotting functions and SARS-CoV-2 proteins, adenovirus, and bacterial proteins associated with moderate-to-severe COVID-19 infections. This study investigated whether polyclonal antibodies (mainly goat and rabbit) against these viruses and bacteria recognize human blood-related proteins. Antibodies against SARS-CoV-2 and adenovirus recognized vWF, PDE and PF4 and SARS-CoV-2 antibodies also recognized additional antigens. Most bacterial antibodies tested (group A streptococci [GAS], staphylococci, Escherichia coli [E. coli], Klebsiella pneumoniae, Clostridia, and Mycobacterium tuberculosis) cross-reacted with CL and PF4. while GAS antibodies also bound to F2, Factor VIII, Factor IX, and vWF, and E. coli antibodies to PDE. All cross-reactive interactions involved antibody-antigen binding constants smaller than 100 nM. Since most COVID-19 coagulopathy patients display autoantibodies against vWF, PDE and PF4 along with CL, combinations of viral and bacterial infections appear to be necessary to initiate their autoimmune coagulopathies.

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Section: Introductionmentioning

confidence: 99%

Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 Coagulopathies

Root‐Bernstein

Huber

Ziehl

2022

IJMS

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Renegade Bacterial Genetic Sequences in a Stealth Adapted Virus: Biological and Diagnostic Implications

2022

Preprint

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There are major differences between viruses, bacteria, and eukaryotic cells in the structuring of their genomes, modes of replication, and capacity to horizontally transfer genetic sequences. DNA sequencing of a cloned African green monkey simian cytomegalovirus (SCMV) indicate the inclusion of certain bacterial and cellular genetic sequences. The virus was cultured from a chronic fatigue syndrome (CFS) patient. It is stealth adapted with the loss or mutation of the genes coding for the relatively few viral components normally targeted by the cellular immune system. This article identifies the likely origins of many of the bacterial-derived genetic sequences present in this virus. There are multiple clones with close but non-identical sequence alignments with different genomic regions of theOchrobactrum quorumnocens A44species of bacteria. Another set of clones matched most closely to diverse genomic regions ofMycoplasma fermentansbacteria. The sequences of several other clones could only be approximately aligned to those of different types of bacteria. The sequence of clone 3B513 is consistent with genetic contributions from the genomes of several types of bacteria. The term viteria refers to viruses with bacteria-derived genetic sequences. Stealth adapted viruses are the likely primary cause of CFS and autism, and possibly act as cofactors in many illnesses including AIDS. The additional incorporation of bacterial sequences into these viruses can potentially lead to the mistaken diagnoses of a bacterial chronic illness rather than a viral infection. Stealth adapted virus testing should be performed in illnesses attributed toMycoplasma, Borrelia, andStreptococcalinfections.

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Classification of Stroke and Non-Stroke Patients from Human Body Movements using Smartphone Videos and Deep Neural Networks

Feliandra

Khadijah

Rachmadi

et al. 2022

2022 International Conference on Advanced Computer Science and Information Systems (ICACSIS)

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Potential association between bacterial infections and ischemic stroke based on fifty case-control studies: A systematic review and meta-analysis

Cited by 6 publications

References 88 publications

Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 Coagulopathies

Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 Coagulopathies

Renegade Bacterial Genetic Sequences in a Stealth Adapted Virus: Biological and Diagnostic Implications

Classification of Stroke and Non-Stroke Patients from Human Body Movements using Smartphone Videos and Deep Neural Networks

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