Renegade Bacterial Genetic Sequences in a Stealth Adapted Virus: Biological and Diagnostic Implications

Wj, Martin

doi:10.1101/2022.10.11.511846

Cited by 3 publications

(4 citation statements)

References 63 publications

(40 reference statements)

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“…44 Most of the remaining bacterial sequences in stealth virus-1 cultures match sequences in Ochrobactrum an alpha-proteobacteria. 36 Furthermore, some of the data are consistent with genetic recombination between sequences from different bacterial strains. It will be of interest to sequence stealth adapted viruses from chronic Lyme disease patients 44 to determine whether this diagnosis is based on the presence of renegade Borrelia burgdorferi sequences, rather than intact bacteria.…”

Section: Renegade Bacterial Sequencesmentioning

confidence: 53%

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Stealth adapted viruses and the epidemic of chronic illnesses

Martin

2024

JHVRV

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Stealth adapted viruses elude recognition by the cellular immune system due to the loss or mutation of genes coding the relatively few components typically targeted by the cellular immune system. Political barriers to accepting the existence of these viruses arose when it became apparent that some of the viruses had originated from the cytomegaloviruses that commonly infected monkeys used to produce poliovirus vaccines. Many virologists are seemingly unaware of the restricted targeting of viral components by the cellular immune system or that genetically defective viruses can continue to replicate and cause cellular damage. Immunologists may also be somewhat reluctant to acknowledge possible non-immunological virus defense mechanisms. There are growing concerns regarding the increasing incidence of major chronic illnesses. Patient support groups are continually advocating for more research on the cause of specific disease entities. There is also a growing sense that special interests may have unintentionally imposed toxic exposures on the public leading to chronic illnesses. Relief from such exposures is being demanded by various Health Freedom movements. This article is intended to better inform the Health Freedom movements and various chronic illness support groups about the existence of stealth adapted viruses. A broader understanding of these viruses and their incorporated renegade cellular and microbial sequences will facilitate therapeutic endeavors, especially those based on the Alternative Cellular Energy (ACE) pathway.

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Section: Renegade Bacterial Sequencesmentioning

confidence: 53%

“…Thirty-four of the sequenced clones from stealth virus-1 matched with very high significance to bacterial sequences. 33,36 There were no bacteria in the cultures that could be maintained in antibiotic-free media. Ten of the bacterial sequences matched regions of the genome of Mycoplasma fermentans.…”

Section: Renegade Bacterial Sequencesmentioning

confidence: 99%

Stealth adapted viruses and the epidemic of chronic illnesses

Martin

2024

JHVRV

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“…It was initially described in a cytopathic virus cultured from a patient with chronic fatigue syndrome (CFS) [2]. Sequence analyses of this prototypic stealth adapted virus indicate the further acquisition of genetic sequences from cellular and bacterial genomes [8][9][10][11][12][13][14][15]. These additional sequences are seemingly abandoning their host in favor of further passage together with the remaining sequences of the originating virus.…”

Section: Introduction and Discussionmentioning

confidence: 99%

“…These additional sequences are seemingly abandoning their host in favor of further passage together with the remaining sequences of the originating virus. As such, they are referred to as renegade sequences [10][11][12][13][14][15]. Although the prototypic stealth adapted virus originated from an African green monkey simian cytomegalovirus (SCMV), the identified cellular-derived renegade sequences are from the human genome rather than from an African green monkey genome [10].…”

Section: Introduction and Discussionmentioning

confidence: 99%

Genetically Unstable Renegade Cellular Sequences in Stealth Adapted Viruses

Martin

2023

Preprint

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Certain classes of viruses have acquired cellular genetic sequences as part of their evolutionary formation. The acquired sequences have essentially become stable components within the virus. The incorporation of cellular sequences can also occur more dynamically as part of an immune evasion mechanism termed stealth adaptation. This involves the loss or mutation of genes coding for the relatively few components that are normally targeted by the cellular immune system. It has been shown to occur with cytomegaloviruses infecting the types of monkeys in which cultured kidney cells were used to produce live polio vaccines. Genetic sequencing of polymerase chain reaction (PCR) products generated in a selection of these viruses has revealed rhesus monkey-derived cellular sequences. Human cellular sequences were present in an African green monkey-derived stealth adapted virus. The human sequences have presumably replaced African green monkey cellular sequences by homologous recombination. Stealth adapted viruses need to be viewed as carriers of potentially highly pathogenic, genetically unstable "renegade" cellular sequences. As discussed in other articles, microbe-derived renegade sequences can also be present in stealth adapted viruses. These findings open a new era in potential virus-induced illnesses.

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Stealth adapted viruses can incorporate renegade cellular and bacterial genetic sequences: public health implications

Wj¹

2023

JHVRV

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The cellular immune system normally responds to relatively few of the different structural components that comprise the complete virus. Mutation or deletion of the genes coding for these few antigenic components is an immune evasion mechanism termed “stealth adaptation.” I initially used this term to describe a virus derived from an African green monkey simian cytomegalovirus (SCMV). This article provides an extended discussion of the Public Health relevance of previously reported findings relating to this virus. Of particular significance, the virus did not evoke inflammation in the chronic fatigue syndrome (CFS) patient from whom the virus was repeatedly cultured, nor in virus inoculated animals. The viral genome consists of multiple fragments of double stranded DNA with lengths of approximately twenty thousand nucleotides (20 kb). This is in marked contrast to the >226 kb size of the normal SCMV genome. Purified virus DNA was cloned, and sequence data were subsequently obtained. Most of the cloned sequences match to regions corresponding in their entirety to only approximately half of the originating SCMV genome. These matching sequences are very unevenly distributed along the SCMV genome. Moreover, there are significant genetic sequence differences between clones matching to identical regions of the SCMV genome. In addition to the SCMV matching sequences, there are sequences that match to regions of the human genome. There are also sequences that match closely to genes of bacterial origin. The major sources of the bacterial sequences in the initially cultured stealth adapted virus are from Mycoplasma fermentans and Ochrobactrum quorumnocens bacteria. These findings have extended the generic concept of stealth adaptation to include not only the loss or mutation of portions of the originating virus genome, which would have otherwise resulted in cellular immune recognition, but also the potential incorporation/acquisition of additional “renegade” genetic sequences from cellular genes and from other microbial genomes. The apparent acquisition of cellular genetic sequences by stealth adapted viruses may potentially lead to the infectious transmission of genetically determined illnesses. The inclusion of bacterial sequences is also concerning since it indicates possible bacteria mediated transmission of infectious stealth adapted viruses. Furthermore, the transmissible bacterial sequences can potentially result in the mistaken diagnosis of a stealth adapted virus infection for a bacterial disease. Examples are likely to include chronic Lyme disease and PANDAS, a severe childhood psychiatric illness. Public Health officials should respond urgently to the existence of stealth adapted viruses.

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Renegade Bacterial Genetic Sequences in a Stealth Adapted Virus: Biological and Diagnostic Implications

Cited by 3 publications

References 63 publications

Stealth adapted viruses and the epidemic of chronic illnesses

Stealth adapted viruses and the epidemic of chronic illnesses

Genetically Unstable Renegade Cellular Sequences in Stealth Adapted Viruses

Stealth adapted viruses can incorporate renegade cellular and bacterial genetic sequences: public health implications

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