Potential Applications of Liposomes to Therapy *

Ryman, Brenda E.; Jewkes, R. F.; Jeyasingh, K.; Osborne, Michael P.; Patel, Harish M.; Richardson, V. J.; Tattersall, Martin H. N.; Tyrrell, D. A. J.

doi:10.1111/j.1749-6632.1978.tb22031.x

Cited by 78 publications

(12 citation statements)

References 62 publications

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“…Segal et al [19] first reported that uptake of liposomeentrapped actinomycin D and liposomal lip ids by regional lymph nodes following intratesticular injections was higher for sonicated small liposomes than for large liposomes. Similar observations of higher lymph node uptake of small liposomes were made follow ing subcutaneous [18] or intramuscular [10] injection. Strand and Persson [20] examined the uptake of radiocolloids in parasternal lymph nodes following subcutaneous injec tion into rabbits and reported that the opti mal particle size for the colloids was 1-10 nm.…”

Section: Discussionsupporting

confidence: 70%

“…9, 14]. Inter stitial injection of liposomes may be useful in the diagnosis and therapy of lymph node métastasés because it is known that lym phatic capillaries preferentially absorb fatty substances and particulate materials [1]: however, only a few reports have appeared which describe lymph node uptake following interstitial injection of liposomes containing cytotoxic drugs [17][18][19]. We have previously reported an enhancement in lymph node up take of melphalan (MPL) produced by lipo somal entrapment of the drug and the effects on lymph node metastasis in rats bearing a MPL-sensitive mammary adenocarcinoma [13].…”

Section: Introductionmentioning

confidence: 99%

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Carrier Activity of Sonicated Small Liposomes Containing Melphalan to Regional Lymph Nodes of Rats

1983

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Tissue distribution following subcutaneous injection of liposomes containing melphalan (MPL) was studied in rats using ¹⁴C-MPL and ³H-phosphatidylcholine. Two types of liposomes, prepared by either a brief or a prolonged sonication, were compared. Brief sonication formed large liposomes of various sizes, while liposomes obtained after a prolonged sonication were small and relatively uniform in size (34 nm in mean diameter). Subcutaneous injection of small liposomes produced a strikingly high and sustained concentration of MPL equivalents in regional lymph nodes. In contrast, most liposomes prepared by a brief sonication appeared to remain at the injection site, and there was only a slight increase in the lymph node concentration of MPL equivalents over the plasma level during the 24-hour experiments.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Carrier Activity of Sonicated Small Liposomes Containing Melphalan to Regional Lymph Nodes of Rats

1983

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“…Recently (13,24,30,31,34). Recent reports from a number of laboratories have dealt with the physicochemical properties of IFN-containing liposomes and the resultant antiviral activities of this drug.…”

mentioning

confidence: 99%

Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model

Weiner

Williams

Birch

et al. 1989

Antimicrob Agents Chemother

116

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The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method of liposomal preparation rather than the lipid composition of the bilayers appeared to be the most important factor for reducing lesion scores. Only liposomes prepared by the dehydration-rehydration method were effective. This finding implied that the dehydration and subsequent rehydration of the liposomes facilitate partitioning of the interferon into liposomal bilayers, where the drug is positioned for transfer into the lipid compartment of the stratum corneum. Liposomes do not appear to function as permeation enhancers but seem to provide the needed physicochemical environment for transfer of interferon into the skin.

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“…The use of controlled or sustained release delivery systems can eliminate some of the problems associated with toxicity and several novel delivery systems have been developed. These include implantable mechanical and osmotic pumps [13] biodegradeable and non biodegradeable polymeric implants [14,15] and small particulate systems including microcapsules, microspheres and liposomes [15][16][17]. The results obtained with all these systems have been encouraging and it is likely that many of them will have eventual clinical applications.…”

Section: Discussionmentioning

confidence: 98%

Sustained release of a corticosteroid using polymeric implants

et al. 1986

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An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral blood leukocytes, lymphoid tissue weight and the inflammatory response has been evaluated. This mode of methylprednisolone administration was compared with conventional systemic therapy and was found to produce rapid and prolonged pharmacological effects at very low plasma levels of drug. A dose response relationship was established and we determined that, for a given quantity of drug, the level and duration of suppression was greater using sustained release therapy. The inflammatory response was also depressed using this mode of administration. These results, coupled with the commercial availability and existing clinical approval of SIMPLEX P bone cement, suggest that further development may lead to useful clinical protocols.

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Potential Applications of Liposomes to Therapy *

Cited by 78 publications

References 62 publications

Carrier Activity of Sonicated Small Liposomes Containing Melphalan to Regional Lymph Nodes of Rats

Carrier Activity of Sonicated Small Liposomes Containing Melphalan to Regional Lymph Nodes of Rats

Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model

Sustained release of a corticosteroid using polymeric implants

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