Potential application of silver nanoparticles to control the infectivity of Rift Valley fever virus in vitro and in vivo

Borrego, Belén; Lorenzo, Gema; Mota‐Morales, Josué D.; Almanza-Reyes, Horacio; Mateos, Francisco; López-Gil, Elena; Losa, Nuria de la; Бурмистров, В. А.; Pestryakov, Alexey; Brun, Alejandro; Bogdanchikova, Nina

doi:10.1016/j.nano.2016.01.021

Cited by 114 publications

(80 citation statements)

References 33 publications

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“…AgNPs have been proven to have broad antimicrobial activity against Gram positive and Gram negative bacteria (Kim et al, 2007;Morones et al, 2005). In addition, some studies have shown that AgNPs also have antiviral activity against a broad range of viruses including herpes simplex virus (Baram-Pinto et al, 2009), influenza virus (Papp et al, 2010;Xiang et al, 2013), hepatitis B virus (Lu et al, 2008, HIV-1 Lara et al, 2010a, b;Sun et al, 2005), Rift Valley fever virus (Borrego et al, 2016), dengue virus (Murugan et al, 2016;Sujitha et al, 2015) and Tacaribe virus (Speshock et al, 2010).…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Drug repurposing for new, efficient, broad spectrum antivirals

2019

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Emerging viruses are a major threat to human health. Recent outbreaks have emphasized the urgent need for new antiviral treatments. For several pathogenic viruses, considerable efforts have focused on vaccine development. However, during epidemics infected individuals need to be treated urgently. High-throughput screening of clinically tested compounds provides a rapid means to identify undiscovered, antiviral functions for wellcharacterized therapeutics. Repurposed drugs can bypass part of the early cost and time needed for validation and authorization. In this review we describe recent efforts to find broad spectrum antivirals through drug repurposing. We have chosen several candidates and propose strategies to understand their mechanism of action and to determine how resistance to antivirals develops in infected cells.

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Section: Silver Nanoparticlesmentioning

confidence: 99%

Drug repurposing for new, efficient, broad spectrum antivirals

2019

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“…The antimicrobial activities of silver have been known since ancient times and used efficiently against a wide range of microorganisms [60]. Silver nanoparticles (AgNPs) are highly lethal against microorganisms and thus have strong antimicrobial effects against wide spectra of microbes, including bacteria [61], fungi [62] and viruses [63]. Silver nanoparticles are able to adhere to microbial cell wall and consequently penetrate it, causing structural changes of the cell membrane and thus making it more permeable [64].…”

Section: Water Disinfectantsmentioning

confidence: 99%

Biogenic Synthesis of Silver Nanoparticle from Mushroom Exopolysaccharides and its Potentials in Water Purification

Adeeyo¹,

Odiyo²

2018

CHEM

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Objective:This study reports a novel eco-friendly biosynthesis of Silver Nanoparticles (AgNPs) from Exopolysaccharides (EPS) ofLentinus edodesafter an attempt to optimise the production of EPS through mutagenesis. It further describes some potential application of silver nanoparticles in water treatment.Methods:A wild strain ofL. edodeswas subjected to UV irradiation, a physical mutagen, at 254 nm. The wild and resultant irradiated strains were then assessed for the production of EPS and subsequent application of the crude EPSs for biosynthesis of AgNPs. The particles were characterised by colour pattern and UV-visible spectroscopy. Based on superior EPS production and nanoparticle attributes, nanoparticles obtained from UV irradiated process were further subjected to Scanning Electron Microscopy (SEM). EPS produced was quantified by the phenol-sulphuric acid method and studied by GC-MS.Results:Results obtained for EPS productivity indicated the presence of monomer sugars such as arabinose (50.65%), mannose (19.20%), mannitol (15.58%), fructose (7.96%), trehalose (6.49%), and glucuronic acid, xylose, galactose and glucose with low percentages of ≤ 0.11. EPS productivity of wild and mutant strains was obtained as 1.044 and 2.783 mg/ml, respectively, after 7 days of fermentation. The result of EPS production for UV irradiated strain corresponds to a yield improvement of 2.7 fold of the wild-type. UV Spectroscopy and SEM analysis studies on EPS nanoparticle product of the improved (UV irradiated) strain indicated the formation of AgNPs at the absorption band of 421 nm with a size range of 50-100 nm.Conclusion:This study, which aimed at eco-friendly synthesis of myco-nanoparticle has established the novel ability ofL. edodes’polysaccharide in silver nanoparticles biosynthesis. It expounded potential frontiers of silver nanoparticles application in the water industry. To the best of the authors’ knowledge, this result represents the first report on the biosynthesis of AgNPs usingL. edode’sEPS.

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“…Silver Nanoparticles. Silver nanoparticles (Ag NPs) are highly toxic to microorganisms and thus have strong antibacterial effects against a wide range of microorganisms, including viruses [11], bacteria [10], and fungi [12]. As a good antimicrobial agent, silver nanoparticles have been widely used for the disinfection of water.…”

Section: Nanomaterials For Water and Wastewater Treatmentmentioning

confidence: 99%

An Overview of Nanomaterials for Water and Wastewater Treatment

Lu¹,

Wang²,

Stoller³

et al. 2016

Advances in Materials Science and Engineering

248

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Due to the exceptional characteristics which resulted from nanoscale size, such as improved catalysis and adsorption properties as well as high reactivity, nanomaterials have been the subject of active research and development worldwide in recent years. Numerous studies have shown that nanomaterials can effectively remove various pollutants in water and thus have been successfully applied in water and wastewater treatment. In this paper, the most extensively studied nanomaterials, zero-valent metal nanoparticles (Ag, Fe, and Zn), metal oxide nanoparticles (TiO2, ZnO, and iron oxides), carbon nanotubes (CNTs), and nanocomposites are discussed and highlighted in detail. Besides, future aspects of nanomaterials in water and wastewater treatment are discussed.

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Potential application of silver nanoparticles to control the infectivity of Rift Valley fever virus in vitro and in vivo

Cited by 114 publications

References 33 publications

Drug repurposing for new, efficient, broad spectrum antivirals

Drug repurposing for new, efficient, broad spectrum antivirals

Biogenic Synthesis of Silver Nanoparticle from Mushroom Exopolysaccharides and its Potentials in Water Purification

An Overview of Nanomaterials for Water and Wastewater Treatment

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