Potential Application of Nanotechnology in Health Care: An Insight

Muhammad, Wali; Haroon, Muhammad; Shah, Muzamil; Ullah, Muhammad Asad; Haleem, Iqra

doi:10.26524/nr1821

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Polystyrene microparticles are one of the earliest materials used to activate T cells in vitro. The particle size of the microparticles is about 4 ~ 5 μ m (13). However, polystyrene is difficult to degrade and easy to form embolism, leading to biological toxicity.…”

Section: Introductionmentioning

confidence: 99%

Nano-lipid Contrast Agent Combined with Ultrasound-Guided SGB in Nursing Treatment of Lymphedema after Breast Cancer Surgery

Zhang¹,

Yuan²,

Zhang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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At present, the application of nano-material technology in nursing treatment is more and more extensive, so the characteristics of a variety of chips tend to the medical field. Lymphedema after breast cancer surgery is common in the recovery period of patients, so the nursing work in this period is very important. In order to explore the effect of nano-lipid contrast agent combined with ultrasound-guided SGB in the nursing treatment of breast cancer postoperative lymphedema, the application scope of nanolipid contrast agent combined with ultrasound-guided SGB and the promotion of nano-materials on cell growth were studied. 11 cases of breast cancer patients in our hospital in 2020 were selected to study the status of lymphedema in the infection stage and recovery stage. The branching effects of nano-lipid contrast agent and ultrasound-guided SGB were evaluated. The results showed that at the same density, the recovery time of lymph tissue in the nano-lipid contrast agent combined with the ultrasound-guided SGB group was significantly shorter than that in the control group. Due to the self-healing state, the recovery time was the most significant 3-7 days after surgery. At this time, the survival rate of selfhealing cells was 34.75%, and that of the nano-lipid contrast agent group was 82.37%, which indicated that the nano-lipid contrast agent combined with ultrasound-guided SGB could effectively play the role of photodynamic therapy and synergistic therapy, and inhibit the growth of tumor cells. At present, many kinds of phototherapeutic agents can inhibit the growth of cancer cells and induce apoptosis of cancer cells. Safe and efficient nano photosensitizers have broad application prospects in the field of cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Nano-lipid Contrast Agent Combined with Ultrasound-Guided SGB in Nursing Treatment of Lymphedema after Breast Cancer Surgery

Zhang¹,

Yuan²,

Zhang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…[ 3,4 ] Currently, nanotechnology in the horizon of medicine offers some exciting possibilities. [ 5,6 ] Some methods are just considered, while others are at various experimental levels, or are currently being used. Nanotechnology has been associated with the medicinal applications of nanoparticles (NPs), which not only involves incorporation in the vaccine to make “nanovaccines” but also the usage of manufactured nanorobots to make repairs at the cellular level (referred as nanomedicine).…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Nanomaterials against Coronaviruses

Muhammad

Zhai

Gao

2020

Macromolecular Bioscience

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NPs may target a desired part of the body, whereas conventional drug formulations typically distribute throughout the entire body. In the case of nanovaccines, they can be designed to better target lymphatic organs and immune cells to promote better immune responses than the conventional vaccines. Sometimes the localized infection is difficult to be reached by the conventional vaccines, but can be cured by the nanovaccines with specific cells or organs-targeting molecules. In some situations, the nano-based systems are used to enhance the solubility of hydrophobic compounds. These systems not only preserve the reliability of antigens toward degradation but also stabilize a large number of therapeutic agents such as peptides, proteins, and nucleic acids. [9] Viral infections can pose challenges for global public health because of their problematic widespreading distribution and their potential to develop through genetic mutation. [10] Viral infections cause a high number of deaths and a disturbing health care system in a few decades. [10] Recently, a new strain of coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) has led to a pandemic situation that killed 597 583 (WHO, July 19, 2020) with millions of cases all over the world. The CoV belongs to the Coronaviridae family of Nidovirales order, [11-13] whose genomes usually range from 26 to 32 kb. [14] These viruses are called Coronaviruses (CoVes) because of the protruding spike proteins on their envelope that give the virions of crown-shaped. [15,16] Six CoVes species are responsible for the infection of humans, in which four of them (229E, OC43, NL63, and HKU1) are predominant and cause symptoms of a common cold in immunocompetent individuals. [17] While the other two strains are known as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which cause fatal diseases. [18,19] The acute respiratory cases appeared in early 2003 in China were caused by SARS-CoV, [20,21] while the MERS-CoV was the responsible pathogen for the Middle East outbreaks of severe respiratory disease in 2012. [22,23] The novel strain (SARS-CoV-2) caused pneumonia that seriously contributed to lung injuries. Identified scanning electron microscopy (SEM) image of SARS-CoV-2 is shown in Figure 1. The disease caused by this serious strain is termed as coronavirus diseases 2019 (COVID-19). To reduce infectious disease transmission, suitable methods are required based on the nature of the disease and mode of transmission. [24] For instance, vaccination is required for some One of the challenges facing by world nowadays is the generation of new pathogens that cause public health issues. Coronavirus (CoV) is one of the severe pathogens that possess the RNA (ribonucleic acid) envelop, and extensively infect humans, birds, and other mammals. The novel strain "SARS-CoV-2" (severe acute respiratory syndrome coronavirus-2) causes deadly infection all over the world and presents a pandemic situation nowadays. The SARS...

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“…Over the last 15 years, nanoparticles (NPs) have found numerous applications in biotechnology and medicine . For example, the plasmonic properties of noble metal NPs are used for imaging applications such as Raman spectroscopy to investigate molecules, pathogens, and tissues .…”

Section: Introductionmentioning

confidence: 99%

Step‐by‐step monitoring of a magnetic and SERS‐active immunosensor assembly for purification and detection of tau protein

Maurer

Frank

Porsiel

et al. 2019

Journal of Biophotonics

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We report a bottom‐up synthesis of iron oxide and gold nanoparticles, which are functionalized and combined to form a nanohybrid serving as an immune sensor, which selectively binds to tau protein, a biomarker for diagnosis of Alzheimer's disease. Detection of the target analyte is achieved by surface‐enhanced Raman scattering originating from the diagnostic part of the nanohybrid that was prepared from Au nanoparticles functionalized with 5,5′‐dithiobis‐(2‐nitrobenzoic acid) as a Raman reporter and monoclonal anti‐tau antibody. The magnetic part consists of FexOy nanoparticles functionalized with polyclonal anti‐tau antibody and is capable to separate tau protein from a complex matrix such as cerebrospinal fluid. We further identified and validated a set of analytical tools that allow monitoring the success of both nanoparticle preparation and each functionalization step performed during the assembly of the two binding sites by an immune reaction. By applying UV/Vis spectroscopy, dynamic light scattering, zeta potential measurements, X‐ray diffraction, small‐angle X‐ray scattering, and transmission electron microscopy, we demonstrate a proof‐of‐concept for a controlled and step‐by‐step traceable synthesis of a tau protein‐specific immune sensor.

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Potential Application of Nanotechnology in Health Care: An Insight

Cited by 6 publications

References 10 publications

Nano-lipid Contrast Agent Combined with Ultrasound-Guided SGB in Nursing Treatment of Lymphedema after Breast Cancer Surgery

Nano-lipid Contrast Agent Combined with Ultrasound-Guided SGB in Nursing Treatment of Lymphedema after Breast Cancer Surgery

Antiviral Activity of Nanomaterials against Coronaviruses

Step‐by‐step monitoring of a magnetic and SERS‐active immunosensor assembly for purification and detection of tau protein

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