Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Oliveira, Ana Flávia Costa da Silveira; Teixeira, Róbson Ricardo; Oliveira, André Silva de; Souza, Ana Paula Martins de; Silva, Milene Lopes da; Paula, Sérgio Oliveira de

doi:10.20944/preprints201703.0118.v1

Cited by 19 publications

(30 citation statements)

References 44 publications

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“…Nowadays, research and development programs are continuously adopting approaches based on plant-based products for the development of drugs. Pure compounds and plant extracts have been investigated for the synthesis of new pharmaceuticals and therapeutics (Oliveira et al 2017). Plants have a variety of secondary metabolites like flavonoids, terpenoids, lignans, tannins, and alkaloids having diverse anti-infection activities, as well as antioxidant activities (Kapoor et al 2017;Akram et al 2018).…”

Section: Plant-based Antiviral Moleculesmentioning

confidence: 99%

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Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

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Section: Plant-based Antiviral Moleculesmentioning

confidence: 99%

“…These include phenolics, carotenoids, terpenoids, and alkaloids. Out of which, the phytochemicals belonging to phenolics, alkaloids, and terpenoids have been explained in further sections (Kapoor et al 2017 (Oliveira et al 2017;Akram et al 2018). These viruses have either DNA or RNA as genetic material.…”

Section: Plant-based Antiviral Moleculesmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

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“…The extracts from the Vitex negundo and Hyptis suaveolens were reported to exhibit 50% viral inhibition against Asian strains at a concentration of 15.62 μg/mL but no inhibition was reported against African strains. They also reported harringtonine (alkaloid extract obtained from Japanese plum yew) inhibited CHIKV infection (EC 50 = 0.24 µM), with minimal cytotoxicity (cell viability >90%) at early stage of viral replication [44]. Esposito et al reported the anti-CHIKV activity of 4βdideoxyphorbol ester with an EC 50 value of 4.0 ± 0.3 μM [45].…”

Section: Chikv Inhibitors From Natural Sourcesmentioning

confidence: 95%

“…Approaches utilizing the administration of neutralizing monoclonal antibodies and the developed VLPs can generate effective immunogenicity and provide safety to the host [43][44][45]. MAbs-targeting epitopes of envelop proteins of CHIKV are disclosed as effective in neutralizing its infection and are patented [62,63,70].…”

Section: Expert Opinionmentioning

confidence: 99%

Antiviral therapeutics for chikungunya virus

Ghildiyal

Gabrani

2020

Expert Opinion on Therapeutic Patents

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Introduction: Chikungunya virus (CHIKV), a reemerging human arthropod borne virus, can causes global epidemic outbreaks and has become a serious health concern due to the unavailability of any antiviral therapy/vaccine. Extensive research has been conducted to target different proteins from CHIKV to curtail the spread of virus. Areas covered: This review provides an overview of the granted patents including the current status of antiviral strategies targeting CHIKV. Expert opinion: Under the current scenario, potential molecules and different approaches have been utilized to suppress CHIKV infection. MV-CHIKV and VRC-CHKVLP059-00-VP vaccine candidates have successfully completed phase I clinical trials and ribavirin (inhibitor) has shown significant inhibition of CHIKV replication and could be the most promising candidates. The drug resistance and toxicity can be modulated by using the inhibitors/drugs in combination. Moreover, nanoparticle formulations can improve the efficacy and bioavailability of drugs.

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“…4 The incidence of DENV has increased approximately 30-fold over the past 50 years. 5 Dengue virus, the causal agent of dengue, has been shown to induce apoptosis in vitro and in vivo. 6,7 The mechanisms that trigger the apoptotic cellular responses, however, have not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

Anti-Dengue Type 2 Virus Activities of Zinc (Ii) Complex Compounds With 2-(2,4 -Dihydroxyphenyl)-3,5,7-Trihydroxycromen-4-One Ligands in Vero Cells

Sucipto¹,

Setyawati

Churrotin

et al. 2019

IJTID

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Dengue virus (DENV) is a disease that is transmitted through Aedes aegypti and Aedes albopictus mosquitoes, and is spread in tropical and sub-tropical regions. Now, dengue or antiviral vaccines for humans do not yet exist, but there are great efforts to achieve this goal. Complex compounds are reported to fungicidal, bactericidal and antiviral activity. Antiviral activity against DENV is an important alternative to the characterization and development of drugs candidate. The purpose of this study was to study zinc(II) compounds with 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxycromen-4-one ligand on DENV-2 replication in Vero cells. Vero cell lines (African green monkey kidney) was used in this study, maintained and propagated in Minimum Essential Eagle Medium containing 10% fetal bovine serum at 37°C in 5% CO2. The activity of dengue virus was carried out by enzyme-immunosorbent assay (ELISA) method and CellTiter96® Non-Radioactive Proliferation. The value of activity inhibition (IC50) of complex compounds with variations of mol metal: ligand 1:2, 1:3, and 1:4 against dengue virus type 2 (DENV2) was 2.44 μg/ml, 2.75 μg/ml, respectively and 2.00 μg/ml, also the toxicity value (CC50) of complex compounds with variation mol metal: ligand 1:4 for Vero cells is 3.59 μg/ml. The results of this study were indicate that these properties have been shown to inhibit anti-dengue type 2 virus (DENV-2), but are also toxic in Vero cells. Including previous study about complex compound interaction with dengue virus type 2 activity, Zn(II) more reactive compound then Cu(II), and Co(II). The comparison with Cu(II) complex compound, it has been revealed that Co(II) and Zn(II) is more toxic, was found to be nontoxic to human erythrocyte cells even at a concentration of 500 μg/ml.

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Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Cited by 19 publications

References 44 publications

Phytochemicals as Antiviral Agents: Recent Updates

Phytochemicals as Antiviral Agents: Recent Updates

Antiviral therapeutics for chikungunya virus

Anti-Dengue Type 2 Virus Activities of Zinc (Ii) Complex Compounds With 2-(2,4 -Dihydroxyphenyl)-3,5,7-Trihydroxycromen-4-One Ligands in Vero Cells

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