Potential Antiviral Properties of Industrially Important Marine Algal Polysaccharides and Their Significance in Fighting a Future Viral Pandemic

Bai, Renu Geetha; Tuvikene, Rando

doi:10.3390/v13091817

Cited by 32 publications

(16 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More than 53% of the global agar production is derived from two primary species of red seaweed, namely Gracilariopsis and Gracilaria, as highlighted by Nasrollahzadeh et al [98]. The high antiviral activity of agarans, evaluated mainly against herpes simplex virus HSV-1 and HSV-2 from the encapsulated viruses [99][100][101][102], is considered to be correlated with the high-molecular-weight galactan sulfate fractions [103] and is mediated through direct interaction with the virus particle rather than by interaction with the host cells or with erythrocytes [104]. Currently, there is only one study, that of Farfour et al, 2022, that has investigated the dynamics of SARS-CoV-2 directly in agar media.…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Lefter,

Balyan,

Balmus

et al. 2024

Microbiology Research

View full text Add to dashboard Cite

Infection with the novel coronavirus SARS-CoV-2, the cause of coronavirus disease (COVID-19), has emerged as a global pandemic, with a high toll on casualties, economic impact, and human lifestyle. Despite the recent approval of various vaccines against the virus, challenges remain, including the limited availability of these vaccines, the prevalent rejection of vaccination by a large proportion of the population, and the recurrent appearance of new variants of the virus due to mutations. This context raises the alarm for scientists and clinicians to seek alternative and complementary therapies. In this context, natural products and their derivatives serve as reservoirs for potential therapeutic compounds that can be exploited in the research and production of antiviral drugs against COVID-19. Among these substances, lectin and polysaccharides isolated from fauna and flora emerge as complementary strategies for treating coronavirus infection. The review objective is to cover and analyze the specific role of polysaccharides and lectins and their synergy in the fight against this deadly SARS-CoV-2 virus. For this purpose, a primary literature search was conducted on Google Scholar, PubMed, and Web of Sciences using relevant keywords like “SARS-CoV-2 Variants”; “Antiviral Strategies”; “Antiviral Polysaccharides”; “Antiviral Lectins”; and “Synergistic effect”. The results demonstrate that lectins and polysaccharides exhibit antiviral activities against SARS-CoV-2 via mechanisms related to binding and steric blocking, the binding of glycan-based decoys, chemical reactions, virus particle disruption strategies, and steric blocking for competitive inhibition to block SARS-CoV-2 and its variants’ entry. In addition, this review analyzes the rationale behind combining polysaccharides and lectins, emphasizing complementary mechanisms of action. By simultaneously targeting multiple stages of the viral life cycle, this dual strategy aims to comprehensively inhibit viral propagation and enhance the durability of antiviral strategies over time.

show abstract

Section: Randomized Clinical Trialsmentioning

confidence: 99%

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Lefter,

Balyan,

Balmus

et al. 2024

Microbiology Research

View full text Add to dashboard Cite

show abstract

“…In addition, seaweed polysaccharides can inhibit viral transcription and replication through direct interference with viral replication enzymes or inhibition on other intracellular targets [ 140 ]. Marine polysaccharides, especially sulfated polysaccharides from marine algae, appear to block viral infection by inhibition of one or more of these stages, with the specific mechanisms dependent on the structure of the individual polysaccharide [ 140 , 141 , 142 , 143 , 144 ].…”

Section: Conclusion and Future Outlooksmentioning

confidence: 99%

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Wei

Wang

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

In recent years, various viral diseases have suddenly erupted, resulting in widespread infection and death. A variety of biological activities from marine natural products have gradually attracted the attention of people. Seaweeds have a wide range of sources, huge output, and high economic benefits. This is very promising in the pharmaceutical industry. In particular, sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. This review focuses on recent advances in antiviral research on the sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan. We hope that this review will provide new ideas for the development of COVID-19 therapeutics and vaccines.

show abstract

“…Starting with the first reported antiviral polysaccharides against mumps and influenza [ 1 , 2 ], several other reports have suggested that polysaccharides and their derivatives are potent antivirals [ 3 ]. The inhibition of human immunodeficiency virus 1 (HIV-1) by polysaccharides and their derivatives was also one of the reported antiviral activities [ 4 , 5 , 6 ]. Studies have also shown that sulfated polysaccharides from different sources showed beneficial effects against HIV infection either inhibiting cell entry or viral replication [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-HIV-1 Activity of Chitosan Oligomers N-Conjugated with Asparagine and Glutamine

Karadeniz

2023

BioTech

View full text Add to dashboard Cite

Chitosan oligomers (COS) are polysaccharides obtained by the hydrolyzation of chitosan. They are water-soluble, biodegradable, and have a wide range of beneficial properties for human health. Studies have shown that COS and its derivatives possess antitumor, antibacterial, antifungal, and antiviral activities. The goal of the current study was to investigate the anti-human immunodeficiency virus-1 (HIV-1) potential of amino acid-conjugated COS compared to COS itself. The HIV-1 inhibitory effects of asparagine-conjugated (COS-N) and glutamine-conjugated (COS-Q) COS were evaluated by their ability to protect C8166 CD4+ human T cell lines from HIV-1 infection and infection-mediated death. The results show that the presence of COS-N and COS-Q was able to prevent cells from HIV-1-induced lysis. Additionally, p24 viral protein production was observed to be suppressed in COS conjugate-treated cells compared to COS-treated and untreated groups. However, the protective effect of COS conjugates diminished by delayed treatment indicated an early stage inhibitory effect. COS-N and COS-Q did not show any inhibitory effect on the activities of HIV-1 reverse transcriptase and protease enzyme. The results suggest that COS-N and COS-Q possess an HIV-1 entry inhibition activity compared to COS and further studies to develop different peptide and amino acid conjugates containing N and Q amino acids might yield more effective compounds to battle HIV-1 infection.

show abstract

Potential Antiviral Properties of Industrially Important Marine Algal Polysaccharides and Their Significance in Fighting a Future Viral Pandemic

Cited by 32 publications

References 165 publications

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

In Vitro Anti-HIV-1 Activity of Chitosan Oligomers N-Conjugated with Asparagine and Glutamine

Contact Info

Product

Resources

About