Potential antitumor effects of egg extract and purple fluid from marine Aplysia fasciata against experimental Ehrlich ascites carcinoma

Salem, Mohamed Labib; Mona, Mohamed H.; Ziada, Mai; Bassiony, Mohamed Aa

doi:10.21608/jcbr.2020.21606.1008

Cited by 1 publication

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“…These previous and our results are in the same line with the findings of Khorana et al (2008). Recently, EAC-inoculation caused considerable leukocytosis, where a high number of leukocytes that linked with the initiation of cancer was found to be one of the risk indicators of venous thrombosis in cancer, which is the second cause of death in cancer as stated by Salem et al (2020). Our finding is in the same line with Badr et al (2011), where the total leukocytic granulocytes were significantly elevated which might be caused by inflammatory response or stress caused by EAC cell growth.…”

Section: Discussionsupporting

confidence: 92%

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Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

El-Bolkiny

Salem

El‐Naggar

et al. 2021

International Journal of Cancer and Biomedical Research

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Background: Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mice. Materials and Methods: Extracts of ROLE and SLRE were examined for their phytochemical activities. To ecaluate their anti-tumor effects, mice were inoculated intraperitoneally (i.p.) with 2.5x10 5 Ehrlich ascites carcinoma (EAC) and then treated i.p. with CIS (dose????) at days 3-7 and with ROLE (dose) or SLRE (dose) at days 3-14. Mice were sacrificed on day 14 for CBC and T-cell analyses. Results: Phytochemical analysis revealed that both ROLE and SLRE showed similar antioxidant activities. Treatment of EAC-bearing mice with CIS induced antitumor efficacy of about 90%. Treatment with CIS in combination of ROLE or SLRE did not further enhance the the antitumor activity of CIS. However, co-administration of ROLE or SLRE with CIS increased significantly the antitumor efficacy of CIS. Flow cytometric analysis showed that the numbers of CD4 + and CD8 + T cells were decreased in EAC bearing mice after treatment with CIS. Treatment with both ROLE and SLRE improved the number of these cells. Conclusion: Combinatorial treatment with rosemary and costus can enhance the antitumor activity of CIS while lower its side effects.

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Section: Discussionsupporting

confidence: 92%

“…Cells were washed twice; RBCs were lysed with ACK and the remaining cells were again washed 3 times and counted. The cell viability was determined by Trypan blue exclusion and consistently exceeded 90% (Salem et al, 2020).…”

Section: Preparation Of Spleen Cell Suspensions and Splenocytes Countmentioning

confidence: 99%

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

El-Bolkiny

Salem

El‐Naggar

et al. 2021

International Journal of Cancer and Biomedical Research

Self Cite

View full text Add to dashboard Cite

show abstract

Potential antitumor effects of egg extract and purple fluid from marine Aplysia fasciata against experimental Ehrlich ascites carcinoma

Cited by 1 publication

References 0 publications

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

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