Potential Antitumor Activity Studies on Some Coordination Compounds of Rare Earth Elements With Antipyrine

Abstract

The aim of this study was to examine the anticancer activity of rare earth elements complexes with antipirin. Materials and methods. We have studied the cytotixic activity of in vitro and antineoplastic activity in vivo of 28 iodides and perchlorates containing as a ligand antipirine. Results. Here we show, that non of tested compounds exert cytotoxic action on 5 human cancer cell lines of different histogenesis at a concentration of 100 ßM. However, we observe that two complexes of antipirine derivatives with iodides of gadolinium and neodymium possess anti-tumor activity in experiments with transplantable solid tumors. Conclusion. The data obtained indicate the feasibility of further studies of these two complexes on a larger number of mice, with changing doses and routes of administration. We also suggest the investigation of these compounds on ascites tumors.

Complexes of Zinc(II)- and Copper(II) Perchlorates with Nicotinamide: Synthesis, Structure, Cytotoxicity

“…The mentioned mechanism is the nonspecific one and platinum-containing compounds demonstrate serious side effects (neuro-, hepato-, and nephrotoxicity). That is why complex compounds of transition metals, rare-earth elements with small organic ligands as potential anticancer pharmacological agents of new generation are of special interest [2][3][4][5][6][7][8][9]. Action of metal-complexes-containing anticancer drugs is based on the different adducts formation with DNA [10].…”