Complexes of Zinc(II)- and Copper(II) Perchlorates with Nicotinamide: Synthesis, Structure, Cytotoxicity

Abstract

Interaction of zinc(II)- and copper(II) perchlorate hexahydrates with nicotinamide (Nia – nicotinamide, niacinamide, 3-pyridinecarboxamide, C 5 H 4 NС(O)NH 2 ) has been studied. It has been demonstrated that complex compounds [Zn(Nia) 2 (H 2 O) 4 ](ClO 4 ) 2 ( 1 ) and [Cu(Nia) 2 (H 2 O) 2 ](ClO 4 ) 2 ⋅ 2H 2 O ( 2 ) are formed in aqueous media at the molar ratio M(ClO 4 ) 2 ⋅ 6H 2 O : Nia = 1 : 2. Both compounds are the ionic ones. Geometry of complex cation ( 1 ) may be represented as a distorted octahedron in which nicotinamide molecules are in the trans -position. The same position of ligands is found for planar complex cation ( 2 ). Cytotoxicity of the prepared compounds (MTT assay) has been determined with respect to dental pulp stem cells (DPSC) and breast cancer cell line MCF-7. Antiproliferative activity has been studied relative to 10 cancer cell lines, complex compound ( 1 ) being the most toxic for C6, Panc-1, U251 cell lines (survivability below 15%).