Potential antimicrobial properties of the Ulva lactuca extract against methicillin-resistant Staphylococcus aureus-infected wounds: A review

Ardita, Nadya Fianny; Mithasari, Lenny; Untoro, Daris; Salasia, Siti Isrina Oktavia

doi:10.14202/vetworld.2021.1116-1123

Cited by 9 publications

(3 citation statements)

References 58 publications

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“…[ 24 ] The recovery rate of MRSA‐infected wounds is very low, and these wounds have become more challenging because antibiotics are ineffective against MRSA. [ 25 ] Therefore, the MRSA strain is employed to evaluate the antibacterial performance of Cu 2.8 O@silicene‐BSA nanosheets. As shown in Figure A, the live/dead staining is first performed to assess the antibacterial effects of testing samples under various treatment conditions.…”

Section: Resultsmentioning

confidence: 99%

Engineering Copper‐Containing Nanoparticles‐Loaded Silicene Nanosheets with Triple Enzyme Mimicry Activities and Photothermal Effect for Promoting Bacteria‐Infected Wound Healing

Zeng,

Gu,

Geng

et al. 2023

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Skin wounds accompanied by bacterial infections threaten human health, and conventional antibiotic treatments are ineffective for drug‐resistant bacterial infections and chronically infected wounds. The development of non‐antibiotic‐dependent therapeutics is highly desired but remains a challenging issue. Recently, 2D silicene nanosheets with considerable biocompatibility, biodegradability, and photothermal‐conversion performance have received increasing attention in biomedical fields. Herein, copper‐containing nanoparticles‐loaded silicene (Cu2.8O@silicene‐BSA) nanosheets with triple enzyme mimicry catalytic (peroxidase, catalase, and oxidase‐like) activities and photothermal function are rationally designed and fabricated for efficient bacterial elimination, angiogenesis promotion, and accelerated wound healing. Cu2.8O@silicene‐BSA nanosheets display excellent antibacterial activity through synergistic effects of reactive oxygen species generated from multiple catalytic reactions, intrinsic bactericidal activity of released Cu2+ ions, and photothermal effects, achieving high antibacterial efficiencies on methicillin‐resistant Staphylococcus aureus (MRSA) of 99.1 ± 0.7% in vitro and 97.2 ± 1.6% in vivo. In addition, Cu2.8O@silicene‐BSA nanosheets exhibit high biocompatibility for promoting human umbilical vein endothelial cell (HUVEC) proliferation and angiogenic differentiation. In vivo experiments reveal that Cu2.8O@silicene‐BSA nanosheets with synergistic photothermal/chemodynamic therapeutics effectively accelerate MRSA‐infected wound healing by eliminating bacteria, alleviating inflammation, boosting collagen deposition, and promoting angiogenesis. This research presents a promising strategy to engineer photothermal‐assisted nanozyme catalysis for bacteria‐invaded wound healing.

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Section: Resultsmentioning

confidence: 99%

Engineering Copper‐Containing Nanoparticles‐Loaded Silicene Nanosheets with Triple Enzyme Mimicry Activities and Photothermal Effect for Promoting Bacteria‐Infected Wound Healing

Zeng,

Gu,

Geng

et al. 2023

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“…have shown antibacterial effects against pathogens such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). These antimicrobial properties are attributed to the presence of sulfated polysaccharides and other bioactive compounds [76].…”

Section: Antimicrobial and Antiviral Activitymentioning

confidence: 99%

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery

Pereira,

Valado

2023

Explor Drug Sci

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Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of seaweed-based drug discovery and highlights the diverse range of bioactive compounds found in seaweeds, including polysaccharides, phlorotannins, pigments, and peptides. These compounds exhibit various pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer effects. Seaweeds have demonstrated particular promise in the areas of cancer research, with certain species showing potent antitumor properties. Additionally, their anti-inflammatory, antimicrobial, and neuroprotective potential has captured scientific interest in the treatment of chronic diseases and neurodegenerative disorders. However, challenges related to compound identification, extraction methods, scalability of seaweed cultivation, and understanding the mechanisms of action still need to be addressed. As researchers employ advanced technologies and dive deeper into the chemical composition of seaweeds, the untapped potential of these marine organisms in drug discovery awaits further exploration and holds significant promise for future therapeutic advancements.

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“…Because of their antibacterial, anti-inflammatory, antioxidant, and anticoagulant properties, these active substances may hasten wound healing in nosocomial wound infections [ 15 , 16 ]. The mechanism of U. lactuca a promising antibacterial as well as an anti-inflammatory agent in wound healing is poorly understood [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic antibacterial effects of Ulva lactuca methanolic extract alone and in combination with different antibiotics on multidrug-resistant Klebsiella pneumoniae isolate

2023

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Various antibiotics are available, including gentamicin, chloramphenicol, ampicillin, amoxicillin, and streptomycin, but they have some restrictions. Many microorganisms are resistant to these medications. A new antimicrobial source must be found or developed to solve this issue. Inhere, extract from seaweeds Ulva lactuca was investigated for its antibacterial activity using a well diffusion assay against Klebsiella pneumoniae, and a promising inhibition zone diameter was recorded to be 14.04 mm. The biochemical structure of the antibacterial compound was determined via GC-MS and FTIR analysis. Also, a micro-dilution assay was used to calculate the minimum concentration that makes inhibition (MIC) to be 1.25 mg/ml from U. extract reliable to prevent the visibility of any bacterial growth, this was followed by examining the antibacterial effect of U. Lactuca methanolic extract alone and the synergetic effect of U. Lactuca methanolic extract in combination with two different antibiotics (gentamicin and chloramphenicol). This was assayed by the agar well diffusion method to achieve promising and strong inhibiting power against K. pneumoniae. It was deduced that the maximum synergism could be achieved by adding 2.5 mg/ml of Ulva methanolic extract to gentamicin (4 µg/ml), and the results were illustrated obviously via transmission electron microscope in which severe morphological deteriorations were experienced by the treated cells. From this study, we can conclude that U. lactucae extract has the power to aid antibiotics in reducing the growth of pathogenic K. pneumoniae.

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Potential antimicrobial properties of the Ulva lactuca extract against methicillin-resistant Staphylococcus aureus-infected wounds: A review

Cited by 9 publications

References 58 publications

Engineering Copper‐Containing Nanoparticles‐Loaded Silicene Nanosheets with Triple Enzyme Mimicry Activities and Photothermal Effect for Promoting Bacteria‐Infected Wound Healing

Engineering Copper‐Containing Nanoparticles‐Loaded Silicene Nanosheets with Triple Enzyme Mimicry Activities and Photothermal Effect for Promoting Bacteria‐Infected Wound Healing

Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery

Synergistic antibacterial effects of Ulva lactuca methanolic extract alone and in combination with different antibiotics on multidrug-resistant Klebsiella pneumoniae isolate

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