Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxan-induced diabetes mellitus

Kumar, Rajesh; Sujatha, D.; Saleem, TS Mohamed; Chetty, C. Madhusudhana; Ranganayakulu, D.

doi:10.2147/jep.s8947

Cited by 15 publications

(2 citation statements)

References 32 publications

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“…The leaves and flowers of this plant are traditionally used in Ayurveda and siddha to treat various disorders (Quattrocchi 2012) and an important medicinal remedy for treating various ailments in African traditional folk medicine system. The leaves are used in treatment of asthma due to the presence of biologically active terpenoids; other medicinal properties of the plant include anti-inflammatory, antihyperglycemic, antihyperlipidemic, anti-helminthic, anti-arthritic, antibacterial, anti-cancerous, and antioxidant activities (Akah et al 2003;Kumar et al 2010;Hamid et al 2011;Stewart et al 2013;Janakiraman et al 2014) and used in the treatment of rheumatism, vermifuge, diabetes, and ulcers (Prasad et al 2013). In addition to its medicinal importance in treating various ailments, A. gangetica is considered a nutritious leafy vegetable with high quantity of beta-carotene, vitamin C, and several mineral constituents.…”

Section: Introductionmentioning

confidence: 99%

In vitro regeneration, antioxidant potential, and genetic fidelity analysis of Asystasia gangetica (L.) T.Anderson

Dilkalal

Akula

Umesh

2021

In Vitro Cell.Dev.Biol.-Plant

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An effective protocol for the plant regeneration via direct and indirect organogenesis has been developed from leaf explants of Asystasia gangetica (L.), cultured on Murashige and Skoog (MS) medium supplemented with various concentrations and combinations of auxin and cytokinins. Approximately 86% of explants produced direct shoots on MS medium containing 0.5 mg L −1 6-benzyladenine (BA) and 10 μg L −1 Triacontanol (TRIA) with a maximum of 4.82 ± 0.29 shoots per leaf segment. For production of callus-mediated plantlets (indirect), primarily callus was induced on MS medium containing 2 mg L −1 2,4dichlorophenoxyacetic acid (2,4-D), which was then subcultured on medium with 0.1 mg L −1 naphthaleneacetic acid (NAA), 0.5 mg L −1 BA, and 1 to 8 mg L −1 2-isopentenyl adenine (2iP) in order to develop organogenic callus and subsequent shoot induction. A maximum of 6.84 ± 0.05 shoots per callus clump was obtained on MS media supplemented with 4 mg L −1 2iP, 0.5 mg L −1 BA, and 0.1 mg L −1 NAA. The shootlets produced roots when cultured on half-strength MS media supplemented with 2 mg L −1 indole-3-butyric acid (IBA). In vitro propagated plantlets were hardened on soil rite and acclimatized to field condition with 85% survivability. The chlorophyll content of acclimatized plants was comparable with that of the mother plant, while stomatal micromorphology of regenerated plants exhibited no abnormalities. The radical scavenging and antioxidant activity of methanolic extract of leaves were measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing ability of plasma (FRAP), and phosphomolybdenum test. In all experiments, regenerated plants exhibited enhanced antioxidant potential indicating micropropagated plants could be exploited for isolation of novel biomolecules. Further, the genetic homogeneity of acclimatized plants was confirmed by PCR-based start codon targeted (SCoT) markers and ycf1b DNA barcoding primers which exhibited monomorphic bands identical to the normal mother plant and no variations were observed.

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Section: Introductionmentioning

confidence: 99%

In vitro regeneration, antioxidant potential, and genetic fidelity analysis of Asystasia gangetica (L.) T.Anderson

Dilkalal

Akula

Umesh

2021

In Vitro Cell.Dev.Biol.-Plant

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“…Thus liver and kidney are first target of the toxic substances which caused the hepatic and renal injuries. Assessment of some serum biomarker enzymes (ALT, AST and ALP) gives the signal for the health status of liver and kidney [ 50 ]. Transaminases ALT and AST mainly present in hepatocyte of liver while ALP is major components of plasma membrane and endoplasmic reticulum of the tissues.…”

Section: Discussionmentioning

confidence: 99%

Toxicity profiling and antioxidant activity of ethyl acetate extract of leaves of Premna integrifolia L. for its application as protective agent against xenobiotics

et al. 2021

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Triticale crisp bread enriched with selected bioactive additives: volatile profile, physical characteristics, sensory and nutritional properties

et al. 2017

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The effect of selected plant additives (couch grass, artichoke, kale, nettle, ground buckwheat husks, broad beans, fenugreek seeds, and extracts of yellow tea and mulberry leaf) on the volatile compounds, color, texture, sensory attributes, polyphenols, and antioxidant properties of triticale crisp bread was studied. The volatile profile of control bread was dominated by lipid oxidation products with hexanal and (E)-2-nonenal predominant. The additives strongly modified the volatile profile of the extruded crisp bread. The greatest differences were recorded in the case of products with artichoke and kale additions, which had respectively about 12 and 8 times higher levels of total volatile compounds than the control crisp bread. The samples containing kale, buckwheat, and fenugreek as well as yellow tea extract characterized high levels of sulfur compounds, with methanethiol predominant. The additives, especially kale, nettle, and artichoke affected the color of the crisp breads, in most cases making them darker. In terms of texture only the crisp bread with addition of buckwheat husk was significantly harder than the control sample. On the basis of sensory evaluation it was stated that among all the additives, the artichoke and fenugreek resulted in dramatic deterioration in the extruded product taste. The used additives also affected the antioxidant properties of triticale crisp bread. The greatest content of total phenolic compounds and the highest antioxidant activity were observed for the bread with yellow tea extract addition (3.5- and 6.5-fold higher, respectively, than in control sample).

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Potential antidiabetic and antioxidant activities of Morus indica and Asystasia gangetica in alloxan-induced diabetes mellitus

Cited by 15 publications

References 32 publications

In vitro regeneration, antioxidant potential, and genetic fidelity analysis of Asystasia gangetica (L.) T.Anderson

In vitro regeneration, antioxidant potential, and genetic fidelity analysis of Asystasia gangetica (L.) T.Anderson

Toxicity profiling and antioxidant activity of ethyl acetate extract of leaves of Premna integrifolia L. for its application as protective agent against xenobiotics

Triticale crisp bread enriched with selected bioactive additives: volatile profile, physical characteristics, sensory and nutritional properties

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