Potential Anticancer Agents--XXXL. The Relationship of Analogues of 1-Methyl-3-nitro-1-nitrosoguanidine (NSC-9369)

N-Methyl-N-nitroso-p-toluenesulfonamide

“…For related structures, see: Hakkinen et al (1988); Lightfoot et al (1993). For the use of the title compound as a potential cancer chemotherapeutic, see: Garcia-Rio et al (2011); Skinner et al (1960). For its use as an antimicrobial, see: Uri & Scola (1992) and as a precursor in methylene production and production of heterocyclic rings, see: Hudlicky (1980).…”

“…(Hudlicky, 1980) Recently, these N-nitroso compounds have gained attention due to their potential cancer chemotherapeutic abilities. (Skinner et al, 1960); (Garcia-Rio et al, 2011) Additionally, the title compound was also found to behave as an antimicrobial agent against yeasts, fungi, Gram-negative, and Gram-positive bacteria. (Uri & Scola, 1992) The title compound was also shown to behave as a nitrosylating reagent in the formation of a new diruthenium complex.…”

Prophage Induction in Lysogenic Escherichia coli with N-Nitroso Compounds and Derivatives

“…Of the seven denitrosated nitrosamidines and nitrosamides tested (Table 2), N-methyl-N-nitroguanidine, 2-nitramino-2-imidazoline, N-methylurea, N-ethylurea, 2-imidazolidone, N-methylurethane, and N-ethylurethane were incapable of prophage induction, although all of their parent N-nitroso derivatives were effective inducers, demonstrating the necessity of the nitroso group for the biological response. Denitrosated derivatives, generally, appear to be biologically inert (11,27,40).…”

Cationic Mixed Micelles as Reaction Medium for Hydrolysis Reactions

“…The N-nitroso compounds are of great interest from a biological point of view, because a wide variety of structurally related compounds possessing the N-nitroso-N-alkyl functionality have demonstrated cancer chemotherapeutic potential [10,11]. Besides, the discovery of the bioregulatory roles of nitric oxide [12][13][14][15][16], and its anti-carcinogen properties [17,18], has greatly increased the interest in nitrosation reactions because nitroso compounds are able to delivery nitric oxide in a controlled manner [19].…”