Potential anticancer activity of Mn (II) complexes containing arginine dithiocarbamate ligand on MCF-7 breast cancer cell lines

Prihantono, Prihantono; Irfandi, Rizal; Raya, Indah; Warsinggih,

doi:10.1016/j.amsu.2020.11.018

Cited by 29 publications

(18 citation statements)

References 30 publications

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“…The UV-vis spectrum of the synthesized in band I showed an absorption band at 268 nm. This band was an intra-ligand transition π→π* of the CS2 group, which was influenced by the hyperconjugation effect of the R group on the nitrogen (N) atom in the region (Prihantono et al, 2020). The shift in band II, which was an intra-ligand transition n → π* of the N=C=S group at 575 nm, was also observed in the Fe(II) isoleucine dithiocarbamate complex.…”

Section: Resultsmentioning

confidence: 82%

“…This phenomenon shows that iron can be applied in biology (Dinda et al, 2020;Irfandi et al, 2019). The dithiocarbamate complex has a cytotoxicity effect (IC 50 =211.53 g/mL) against the MCF-7 breast cancer cell line and has a potential as an effective anti-cancer agent (Prihantono et al, 2020). The dithiocarbamate ligand acts as a selective inhibitor of mitochondrial respiration.…”

Section: Research Articlementioning

confidence: 91%

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A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Irfandi

Riswandi

Raya

et al. 2022

Asian Pac J Cancer Prev

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Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2. Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ ADMET properties were also carried out on the complex. Result: Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399-599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC 50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis. Conclusion: Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein -ACE2 receptors, and inhibiting major proteases and 3Clpro.

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Section: Resultsmentioning

confidence: 82%

Section: Research Articlementioning

confidence: 91%

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Irfandi

Riswandi

Raya

et al. 2022

Asian Pac J Cancer Prev

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“…In other words, the dose of cytotoxic compound where 50% viability is achieved is the IC 50 when testing viability through an MTT assay [88,89]. Concerning the IC 50 standard for cytotoxic samples, the Mn(II) coordination compounds belong to the active cytotoxic category because the IC 50 value occurs less than 100 μg/mL based on Prayong classification [77]. Damercheli (Adpa � bis(2-pyridylmethyl) amino-2-propionic acid), with possible reaction mechanisms was investigated [84].…”

Section: Damercheli Et Al's Study Damercheli Et Al Synthesized Four M...mentioning

confidence: 99%

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Odularu

2022

Journal of Chemistry

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Choice of ligands is significant to successful synthesis of metal complexes (coordination compounds). This study reports the use of Schiff base as the right ligand to control the poor bioavailability and neurodegenerative toxicity challenges of manganese ion. In line with this study, document analysis was used as the methodological approach to evaluate the significance of Schiff base ligands in easing these manganese’s challenges and aligning the resultant coordination compounds (manganese Schiff base complexes) as therapeutic agents in anticancer studies. Report also involves crystallographic studies where single crystal X-ray crystallography was used as a chemical characterization technique. In addition, molecular docking studies, MOE2008, and AutoDock software were used to reveal the mode of interaction between the Schiff base and the manganese(II) and (III) ions, as well as scrutinizing the biological efficacy of the manganese(II) and manganese(III) Schiff bases coordination compounds as anticancer agents against some anticancer cell lines. Conclusion drawn was that manganese(II) and manganese(III) Schiff bases coordination compounds gave more active and potent activities than the corresponding Schiff bases. As a result, challenges of neurodegenerative toxicity and poor bioavailability of manganese ion were overcome, and the chelation therapy was fulfilled. Results from single crystal X-ray crystallography confirmed the successful synthesis of manganese(II) and manganese(III) Schiff bases coordination compounds and revealed the mechanism of reaction, while the molecular docking buttressed the biological activities of the Schiff base ligand and manganese Schiff base coordination compounds by portraying the structure activity relationship (SAR) between either Schiff base or the manganese Schiff base coordination compounds and the virtual cancer cell line (receptor protein), where hits were obtained for lead optimizations.

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“…The Mn(II) 1 complex was identified as being active against cancer cells because its IC 50 value showed a link between its cytotoxic activity and a positive control, cisplatin. The Mn(II) argininedithiocarbamate complex was more effective against MCF-7 cancer cells, when compared to the active compound from Dioscorea esculenta L. [55,57]. The Mn(II) complex is classified as moderately cytotoxic according to the IC 50 standard for cytotoxic samples because the IC 50 value falls between 100 and 1000 μg/mL [55,58].…”

Section: ■ Cytotoxic Action Of Mn(ii) Dithiocarbamate Complexes Again...mentioning

confidence: 99%

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

et al. 2022

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The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.

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Potential anticancer activity of Mn (II) complexes containing arginine dithiocarbamate ligand on MCF-7 breast cancer cell lines

Cited by 29 publications

References 30 publications

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19)

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

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