Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ

Gürbüz, Perihan; Martı́nez, Ana; Pérez, Concepción; Martínez-González, Loreto; Göğer, Fatih; Ayran, İrem

doi:10.1016/j.indcrop.2019.05.080

Cited by 33 publications

(18 citation statements)

References 41 publications

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“…These behavioral test results are in line with previous reports, which demonstrated the potential anti-AD effects of selected Lamiaceae plants [ 91 ]. Altogether, our study provides evidence that OmEO ameliorates Aβ-induced perturbations, such as memory deficits, and offers insights into the cellular and molecular mechanisms involved in the protective effects of this essential oil against Aβ-induced cognitive dysfunctions.…”

Section: Resultssupporting

confidence: 92%

Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer’s Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study

et al. 2020

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Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in traditional medicine since ancient times as culinary herbs and remedies. The aim of the present study was to evaluate the chemical composition, as well as the biochemical and cellular activities of freshly prepared Origanum majorana L. essential oil (OmEO) in an Alzheimer’s disease (AD) amyloid beta1-42 (Aβ1-42) rat model. OmEO (1% and 3%) was inhaled for 21 consecutive days, while Aβ1-42 was administered intracerebroventricularly to induce AD-like symptoms. Our data demonstrate that OmEO increased antioxidant activity and enhanced brain-derived neurotrophic factor (BDNF) expression, which in concert contributed to the improvement of cognitive function of animals. Moreover, OmEO presented beneficial effects on memory performance in Y-maze and radial arm-maze tests in the Aβ1-42 rat AD model.

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Section: Resultssupporting

confidence: 92%

Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer’s Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study

et al. 2020

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“…The methanolic extracts of the above species and M. aquatica and M. suaveolens showed antioxidant and lipid peroxidation inhibition activities [ 73 ], as well as a monoamine oxidase-A (MAO-A) inhibition activity, indicating an antidepressant effect [ 90 ]. M. piperita 70% methanol extract containing flavones and phenolic acids inhibited β-secretase (the enzyme involved in the formation of Aβ), glycogen synthase kinase (GSK-3β), and casein kinase 1δ (CK-1δ) (the enzymes involved in the pathological accumulation of tau) [ 91 ]. The methanolic extracts of M. pulegium, M. rotundifolia, M. villosa, M. arvensis, M. aquatica , and M. piperita showed antioxidant and metal ion chelating ability [ 92 ].…”

Section: Bioactivities Of Mentha Extracts Relatmentioning

confidence: 99%

Potential Role of Phenolic Extracts of Mentha in Managing Oxidative Stress and Alzheimer’s Disease

et al. 2020

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With an increase in the longevity and thus the proportion of the elderly, especially in developed nations, there is a rise in pathological conditions that accompany ageing, such as neurodegenerative disorders. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive and memory decline. The pathophysiology of the disease is poorly understood, with several factors contributing to its development, such as oxidative stress, neuroinflammation, cholinergic neuronal apoptotic death, and the accumulation of abnormal proteins in the brain. Current medications are only palliative and cannot stop or reverse the progression of the disease. Recent clinical trials of synthetic compounds for the treatment of AD have failed because of their adverse effects or lack of efficacy. Thus, there is impetus behind the search for drugs from natural origins, in addition to the discovery of novel, conventional therapeutics. Mints have been used traditionally for conditions relevant to the central nervous system. Recent studies showed that mint extracts and/or their phenolic constituents have a neuroprotective potential and can target multiple events of AD. In this review, we provide evidence of the potential role of mint extracts and their derivatives as possible sources of treatments in managing AD. Some of the molecular pathways implicated in the development of AD are reviewed, with focus on apoptosis and some redox pathways, pointing to mechanisms that may be modulated for the treatment of AD, and the need for future research invoking knowledge of these pathways is highlighted.

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“…From another point of view, β-secretase is a key enzyme in the amyloidogenic pathway and its activity leads to the accumulation of neurotoxic forms of Aβ (Hu et al, 2010;Venugopal et al, 2008). It was found that glycogen synthase kinase-3β (GSK-3β) has been actively involved with Aβ toxicity and tau pathologies (Takashima, 2006) and that methanolic extract of MO has inhibitory effects on GSK-3β and β-secretase (Gürbüz et al, 2019) Acetylcholinesterase inhibitory effect of Melissa officinalis One of the pathological factors of AD is the reduction of acetylcholine (Ach) neurotransmission in the brain areas dealing with learning and memory (Quirion, 1993). Acetylcholinesterase (AChE) is primarily responsible for the hydrolysis of ACh and its synaptic clearance (Soreq and Seidman, 2001).…”

Section: Melissa Officinalis and Alzheimer's Diseasementioning

confidence: 99%

Melissa officinalis: a memory enhancer remedy

Eivani

Khosronezhad

2020

Physiol Pharmacol

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Melissa officinalis (MO) is a perennial herb and it is a member of Lamiaceae family. MO is native to Europe and the leaves of the plants are used in traditional medicine for its effects on the central nervous system functions such as sedation, anxiolytic and memory enhancement. Furthermore, MO has antioxidant and anti-inflammatory effects. Convincing evidence shows that molecular changes such as oxidative stress and inflammation are associated with a decline in cognitive abilities, including learning and memory. MO and its main ingredient, rosmarinic acid, possess robust anti-oxidant and anti-inflammatory effects. Besides, animal model studies have shown that MO and rosmarinic acid can improve memory loss in Alzheimer's disease. In this review beneficial implications of MO have been discussed.

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Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ

Cited by 33 publications

References 41 publications

Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer’s Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study

Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer’s Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study

Potential Role of Phenolic Extracts of Mentha in Managing Oxidative Stress and Alzheimer’s Disease

Melissa officinalis: a memory enhancer remedy

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