Potential and Emerging Treatment Options for Ebola Virus Disease

Bishop, Bryan M.

doi:10.1177/1060028014561227

Cited by 98 publications

(83 citation statements)

References 57 publications

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“…63 Ongoing investigations within the scope of treatments for Ebola include ZMapp, TKM-Ebola, BCX-4430, antivirals (brincidofovir and favipiravir), plasma transfusions from survivors and phosphorodiamidate morpholino oligomer (POMs). 11,62,64,65 ZMapp is a cocktail of monoclonal antibodies already used on victims of the current outbreak, but whose results have not yet been published. 66 In NHPS, ZMapp was able to reverse the spread of the Ebola virus 5 days after exposure.…”

Section: Pathophysiology Clinical Manifestations and Diagnosismentioning

confidence: 99%

Ebola virus – from neglected threat to global emergency state

Pacheco¹,

Rodrigues

Lisboa

2016

Rev. Assoc. Med. Bras.

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Objective: This review aims to update knowledge about Ebola virus disease (EVD) and recent advances in its diagnosis, treatment and prevention. Method: A literature review was performed using the following databases: ISI Web of Knowledge, PubMed, IRIS, Scopus and the websites of the CDC and the WHO. Additionally, we have included articles and reports referenced in the basic literature search, and news that were considered relevant. Results: The Ebola virus, endemic in some parts of Africa, is responsible for a severe form of hemorrhagic fever in humans; bats are probably its natural reservoir. It is an extremely virulent virus and easily transmitted by bodily fluids. EVD's complex pathophysiology, characterized by immunosuppression as well as stimulation of an intense inflammatory response, results in a syndrome similar to septic shock. The diagnosis is difficult due to the initial symptoms that mimic other diseases. Despite the high mortality rates that can amount to 90%, a prophylaxis (chemical or vaccine) or effective treatment does not exist. Two vaccines and experimental therapies are being developed for the prevention and treatment of EVD. Conclusion: Although the virus is known for about 40 years, the lack of knowledge obtained and the disinterest of government authorities in the countries involved justify the state of emergency currently exists regarding this infectious agent. Only the coordination of multiple entities and the effective commitment of the international community will facilitate the control and effective prevention of EVD.

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Section: Pathophysiology Clinical Manifestations and Diagnosismentioning

confidence: 99%

Ebola virus – from neglected threat to global emergency state

Pacheco¹,

Rodrigues

Lisboa

2016

Rev. Assoc. Med. Bras.

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“…Adminis- tration of IV fluids, replacement of electrolytes, treatment of concurrent infections and secondary bacterial infections, nutritional support, administration of antinauseants and analgesics, and management of bleeding are essential aspects of care for those with EVD. 6 As clinical trials are conducted, investigational treatments for EVD may play a larger role. Investigational medications include brincidofovir, favipiravir, TKM-Ebola, ZMapp, amiodarone, chloroquine, clomiphene, dronedarone, lamivudine, and verapamil (Table 2).…”

Section: Treatmentmentioning

confidence: 99%

“…6,7 Supportive care may allow time for the development of adequate antibody response. Adminis- tration of IV fluids, replacement of electrolytes, treatment of concurrent infections and secondary bacterial infections, nutritional support, administration of antinauseants and analgesics, and management of bleeding are essential aspects of care for those with EVD.…”

Section: Treatmentmentioning

confidence: 99%

“…Investigational medications include brincidofovir, favipiravir, TKM-Ebola, ZMapp, amiodarone, chloroquine, clomiphene, dronedarone, lamivudine, and verapamil (Table 2). 6,7 Therapies based on blood products obtained from convalescing EVD patients and vaccines, including the VSV-EBOV vaccine developed by the National Microbiology Laboratory of the Public Health Agency of Canada, are also being assessed for their potential use in treating and preventing EVD. …”

Section: Treatmentmentioning

confidence: 99%

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Ebola Virus Disease: What Canadian Hospital Pharmacists Need To Know

Ramsey

Tung

Balogh

et al. 2015

CJHP

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“…[28][29][30][31][32][33][34][35][36][37][38] There is also a need to increase health workers' understanding on Ebola disease to improve healthcare like any other viral disease. [39] …”

Section: Drug and Vaccine Developmentmentioning

confidence: 99%

Past, Present and Future about Ebola Virus Diseases: An Updated Review

Mali¹,

Swapnil²,

Jadhav³

et al. 2016

JPPCM

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Ebola virus is responsible for the Ebola virus diseases. The epidemic of Ebola hemorrhagic fever is a deadly disease of animal can also be transmitted to human and non-human primates. The virulence of Ebola virus involved in several immune evasion mechanisms that include an inhibition of type I interferon responsible for innate immunity, epitope masking, etc. recently Ebola virus is sexually transmitted which was reported in Liberia has associated with new clusters in regions previously declared Ebola-free. There is no appropriate antiviral vaccine or therapy is not available to work against EBOV infection in humans. However, supportive recovery practices are performed include high-fluid intake, ventilator support and broad-spectrum antibiotic therapy. The treatment and diagnosis is very important because these kind of dangerous viruses are possibly used for bio-weapons. The present review describes briefly about virology, epidemiology, pathophysiology, transmission, diagnosis and treatment of Ebola viral disease.

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Potential and Emerging Treatment Options for Ebola Virus Disease

Abstract: Ebola virus is highly virulent and fatal, and treatment options are limited. Several experimental and existing therapies may be options for preventing and treating Ebola virus disease.

Cited by 98 publications

References 57 publications

Ebola virus – from neglected threat to global emergency state

Ebola virus – from neglected threat to global emergency state

Ebola Virus Disease: What Canadian Hospital Pharmacists Need To Know

Past, Present and Future about Ebola Virus Diseases: An Updated Review

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