Potent inhibitory action of red wine polyphenols on human breast cancer cells

Abstract

Breast cancer (one of the most common malignancy in Western societies), as well as esophagus, stomach, lung, bladder, and prostate cancer, depend on environmental factors and diet for growth and evolution. Dietary micronutriments have been proposed as effective inhibitory agents for cancer initiation, progression, and incidence. Among them, polyphenols, present in different foods and beverages, have retained attention in recent years. Red wine is a rich source of polyphenols, and their antioxidant and tumor arresting effects have been demonstrated in different in vitro and in vivo systems. In the present study, we have measured the antiproliferative effect of red wine concentrate, its total polyphenolic pool, and purified catechin, epicatechin, quercetin, and resveratrol, which account for more than 70% of the total polyphenols in red wine, on the proliferation of hormone sensitive (MCF7, T47D) and resistant (MDA-MB-231) breast cancer cell lines. Our results indicate that polyphenols, at the picomolar or the nanomolar range, decrease cell proliferation in a dose- and a time-dependant manner. In hormone sensitive cell lines, a specific interaction of each polyphenol with steroid receptors was observed, with IC(50)s lower than previously described. Interaction of polyphenols with steroid receptors cannot fully explain their inhibitory effect on cell proliferation. In addition, discrete antioxidant action on each cell line was detected under the same concentrations, both by modifying the toxic effect of H(2)O(2), and the production of reactive oxygen species (ROS), after phorbol ester stimulation. Our results suggest that low concentrations of polyphenols, and consecutively, consumption of wine, or other polyphenol-rich foods and beverages, could have a beneficial antiproliferative effect on breast cancer cell growth.

Phenolic Composition, Antioxidant Capacity and in vitro Cytotoxicity Assessment of Fruit Wines

“…2). Individual phenol- ic compounds and phenolic extracts of fruit and wine have proven to be very active antiproliferative agents (25,49,50). Hence, the six samples were selected on the basis of given phenolic abundance and diversity among wines (Table 3) in order to study their cytotoxicity eff ects.…”

An Analogue of Resveratrol HS-1793 Exhibits Anticancer Activity Against MCF-7 Cells Via Inhibition of Mitochondrial Biogenesis Gene Expression

“…Many in vitro and animal model studies have shown that resveratrol treatment exhibits anticancer effects. For example, resveratrol treatment can reduce proliferation of several mammalian cancer cell lines (Bhat et al, 2001;Damianaki et al, 2000;Jang et al, 1997) and induce apoptosis in skin, colon, and breast cancer models in vivo (Alirol and Martinou, 2006;Bove et al, 2002;Fremont, 2000;Gusman et al, 2001;Hsieh et al, 1999). Furthermore, many studies have demonstrated that resveratrol can inhibit several events during carcinogenesis (e.g., tumor initiation, promotion and progression) (Bishayee 2009).…”

Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells

“…Resveratrol has recently attracted considerable interest because of its inhibitor activity on multiple cellular events associated with carcinogenesis (Jang et al, 1997;Runqing et al, 1999). Resveratrol has been shown to have potent growth inhibitory effects on various cancer cells such as colonic tumor cells (Schneider et al, 2000), leukemic cells (Gautam et al, 2000;Dorrie et al, 2001), breast and prostate cancer cells (Mitchell et al, 1999;Damianaki et al, 2000), and has been suggested as one of the most promising cancer chemopreventive agents.…”