Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans

Endo, Eliana Harue; Cortez, Diógenes Aparı́cio Garcia; Ueda-Nakamura, Tânia

doi:10.1016/j.resmic.2010.05.002

Cited by 200 publications

(157 citation statements)

References 17 publications

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“…Interestingly, this phenolic acid also possessed the capability to totally eradicate C. parapsilosis ATCC 22019 ( Figure 1C) and C. tropicalis ATCC 750 ( Figure 1D) planktonic cells at concentrations higher than 0.625 (p < 0.001) and 1.25 mg/ml (p < 0.001), respectively. Despite the fact that the mechanism of action of gallic acid on yeast cells has not been widely understood, it can be proposed that it acts by disrupting the structure of the cell membrane and inhibiting the normal budding process [38][39][40]. Candida glabrata ATCC 2001 was the species that, in general, presented the highest initial reduction for all Figure 1A).…”

Section: Resultsmentioning

confidence: 99%

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

et al. 2014

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Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells. Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units. Results: MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms. Conclusion: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.

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Section: Resultsmentioning

confidence: 99%

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

et al. 2014

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“…Pomegranate pericarp (peel, rind) and seeds contain several high-value compounds, particularly punicic acid, punicalgins, flavones, flavonones, and flavanols, with beneficial health promoting potentials (Barberan et al 2006). The pomegranate peel and seed extracts have been shown to prevent liver fibrosis and exhibit anti-inflammatory, anti-mutagenic, and antimicrobial activities (Çayır et al 2011;Zahin et al 2010;Endo et al 2010). The diverse beneficial effects of these biomolecules stimulated their use in numerous novel functional food formulations that replies to the local and international market tendencies.…”

Section: Introductionmentioning

confidence: 99%

Pomegranate and mint syrup addition to green tea beverage stabilized its polyphenolic content and biofunctional potentials during refrigerated storage

Dhaouadi

Belkhir

Raboudi³

et al. 2015

J Food Sci Technol

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slight increase of the extractable polyphenolics in PS and MS during the storage might explain in part the relatively limited decrease of GTPS and GTMS total phenolic content. However, chromatographic examination proved that some tea compounds, particularly caffeine, were preserved following PS and MS supplementation. Likewise, syrups'addition to GT significantly (P<0.5) limited the reduction of its antioxidant capacity as revealed by the DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azino-bis-(3-ethylbenzthialzoline-6-sulfonic acid)) assays. As expected, the antimicrobial trials showed that Gram (+) Staphylococcus aureus and Staphylococcus epidermidis were the most sensitive strains to tea polyphenols. The syrups supplementation noticeably preserved the tea bacteriostatic and bactericide activities during storage. The obtained analytical results demonstrate that MS or PS addition to green tea beverage stabilized its polyphenolic content and biofunctional properties during refrigerated storage, thus, scientifically supporting this popular practice in the Mediterranean countries.

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“…In a recent study, Candida spp. were incubated with punicalagin or a pomegranate peel extract (Endo et al, 2010). Punicalagin showed strong antifungal activities against C. albicans and Candida parapsilosis, while the pomegranate peel extract did not show any antifungal activity.…”

Section: Effects Of Pomegranate Phenolic Compounds On the Gut Microflmentioning

confidence: 98%

The Use of Pomegranate (Punica granatum L.) Phenolic Compounds as Potential Natural Prevention Against IBDs

Hollebeeck¹,

Larondelle²,

Schneider³

et al. 2012

Inflammatory Bowel Disease - Advances in Pathogenesis and Management

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Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans

Cited by 200 publications

References 17 publications

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

Antifungal Activity of Phenolic Compounds Identified in Flowers from North Eastern Portugal Against Candida Species

Pomegranate and mint syrup addition to green tea beverage stabilized its polyphenolic content and biofunctional potentials during refrigerated storage

The Use of Pomegranate (Punica granatum L.) Phenolic Compounds as Potential Natural Prevention Against IBDs

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