Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide

Maeda, Megumi; Mizuno, Yuji; Wakita, Masahito; Yamaga, Toshitaka; Nonaka, Kiku; Shin, Min-Chul; Shoudai, Kiyomitsu; Akaike, Norio

doi:10.1016/j.brainresbull.2013.09.003

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…In order to test the potential involvement of NPRs in NPs-mediated BP reduction, the similar experiments were also carried out with anantin (1 mg/mL, acetonitrile (ACN) solution, NPRA inhibitor) [ 31 ], sphingosine 1-phosphate (S-1-P, 4 mg/mL, NaOH solution, NPRB inhibitor) [ 32 ], and ring-deleted ANP analogue (cANP 4–23 ,1 mg/mL, ACN solution, NPRC activator) [ 33 ] before NG microinjection of NPs. As expected, these inhibitors/activators did not induce a significant BP drop, but abolished the effect of NPs on MAP reduction with different affinity ( Figure 1 F–H).…”

Section: Resultsmentioning

confidence: 99%

Natriuretic Peptides—New Targets for Neurocontrol of Blood Pressure via Baroreflex Afferent Pathway

Cui

Zhang

et al. 2022

IJMS

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Natriuretic peptides (NPs) induce vasodilation, natriuresis, and diuresis, counteract the renin–angiotensin–aldosterone system and autonomic nervous system, and are key regulators of cardiovascular volume and pressure homeostasis. Baroreflex afferent pathway is an important reflex loop in the neuroregulation of blood pressure (BP), including nodose ganglion (NG) and nucleus tractus solitarius (NTS). Dysfunction of baroreflex would lead to various hypertensions. Here, we carried out functional experiments to explore the effects of NPs on baroreflex afferent function. Under physiological and hypertensive condition (high-fructose drinking-induced hypertension, HFD), BP was reduced by NPs through NG microinjection and baroreflex sensitivity (BRS) was enhanced via acute intravenous NPs injection. These anti-hypertensive effects were more obvious in female rats with the higher expression of NPs and its receptor A/B (NPRA/NPRB) and lower expression of its receptor C (NPRC). However, these effects were not as obvious as those in HFD rats compared with the same gender control group, which is likely to be explained by the abnormal expression of NPs and NPRs in the hypertensive condition. Our data provide additional evidence showing that NPs play a crucial role in neurocontrol of BP regulation via baroreflex afferent function and may be potential targets for clinical management of metabolic-related hypertension.

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Section: Resultsmentioning

confidence: 99%

Natriuretic Peptides—New Targets for Neurocontrol of Blood Pressure via Baroreflex Afferent Pathway

Cui

Zhang

et al. 2022

IJMS

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“…Anantin has been used extensively as an antagonist to investigate the role and molecular mechanisms of the natriuretic system (recent selection: Citarella et al 2009;Abraham et al 2010;Hrometz et al 2011;Baetz et al 2012;Bian et al 2012;Maeda et al 2013;Vilotti et al 2013) and is cited in more than 100 patents. However, most of the studies reported have used commercially available versions of anantin, which are peptides obtained by solid-phase synthesis.…”

Section: Resmentioning

confidence: 99%

Lasso Peptides

Zirah

Rebuffat

2015

SpringerBriefs in Microbiology

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SpringerBriefs in Microbiology present concise summaries of cutting-edge research and practical applications across a wide spectrum of fields. Featuring compact, authored volumes of 50 to 125 pages, the series covers a range of content from professional to academic. Typical topics might include:• A timely report of state-of-the art analytical techniques • A bridge between new research results published in journal articles and a contextual literature review • A snapshot of a hot or emerging topic • An in-depth case study or clinical example • A presentation of core concepts that students must understand in order to make independent contributions • Best practices or protocols to be followed • A series of short case studies SpringerBriefs in Microbiology showcase basic and translational research from a global author community. Briefs allow authors to present their ideas and readers to absorb them with minimal time investment, and will be published as part of Springer's eBook collection, with millions of users worldwide. In addition, Briefs will be available for individual print and electronic purchase.Briefs are characterized by fast, global electronic dissemination, standard publishing contracts, standardized manuscript preparation and formatting guidelines, and expedited production schedules. We aim for publication 8-12 weeks after acceptance.More information about this series at

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Biological Activities of Lasso Peptides and Structure–Activity Relationships

Zirah

Rebuffat

2014

SpringerBriefs in Microbiology

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Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide

Cited by 6 publications

References 23 publications

Natriuretic Peptides—New Targets for Neurocontrol of Blood Pressure via Baroreflex Afferent Pathway

Natriuretic Peptides—New Targets for Neurocontrol of Blood Pressure via Baroreflex Afferent Pathway

Lasso Peptides

Biological Activities of Lasso Peptides and Structure–Activity Relationships

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