Potensi Senyawa Aktif Biji Kopi sebagai Imunomodulator (Ulasan)

Assa, Asma; Indriana, Dwi; Amalia, Andi Nur; Wulandari, Rahayu

doi:10.26578/jrti.v15i2.6602

Cited by 2 publications

(3 citation statements)

References 21 publications

(23 reference statements)

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“…Immunomodulators are a certain type of compound that can balance the body's defenses both non-specifically and specifically, through immune mechanisms or cellular or humoral defense. Immunomodulator or biological respons modifier consists of various kinds of ingredients, both chemical, synthetic and natural, which are used in immunotherapy to restore the body's immune imbalance [29].…”

Section: Immunomodulatorsmentioning

confidence: 99%

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The potential of caffeine contained in the coffee to modulate the immune system of the COVID-19 sufferers: A review

Anis Irmawati,

Mochamad Daffa Athallah,

Retno Indrawati Roestamadji

et al. 2023

World J. Adv. Res. Rev.

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Background: The COVID-19 pandemic is a worldwide epidemic caused by the SARS-CoV-2 virus, initially detected in Wuhan City, Hubei, China in December 2019. This presents an unparalleled difficulty in identifying efficacious medications for treatment. Despite numerous clinical trials employing various medicines, there remains a dearth of targeted therapies for COVID-19. The progression of COVID-19 clinical symptoms, for example a severe pneumonia, arespiratory distress syndrome (ARDS), and multiorgan failure, is a result of an exaggerated immune response characterized by increased inflammation, oxidation, and cytokine storm. Presently, coffee beans contain caffeine, which is a highly consumed chemical. Caffeine exerts beneficial benefits on the human body, influencing multiple systems such as the immunological system, central nervous system, digestive system, and respiratory system. The impact of caffeine is contingent upon the quantity and composition of the product in which it is present. Objective: Analyze the potential of caffeine as an immunomodulator in COVID-19 sufferers. Discussion: Caffeine functions as an agonist of TAS2R receptors and an antagonist of adenosine receptors. The immunomodulatory properties of caffeine can assist in diminishing the severity of SARS-CoV-2 infection by stimulating adenylyl cyclase, which converts ATP into cAMP. The heightened level of cAMP stimulates the intiation of protein kinase A (PKA), which subsequently suppresses the secretion of pro-inflammatory cytokines. Furthermore, caffeine has the ability to suppress the generation of reactive oxygen species (ROS), hence reducing the unleash of pro-inflammatory cytokines. Conclusion: Caffeine provides health benefits with its immunomodulating properties to COVID-19 patients and can be regarded as a supplementary treatment in patients with COVID-19.

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Section: Immunomodulatorsmentioning

confidence: 99%

“…Among the many possible benefits of caffeine, many studies have examined its potential to influence the immune system and function as an immunomodulator [29,43]. Caffeine is known as an adenosine receptor antagonist and TAS2R receptor agonist.…”

Section: Caffeinementioning

confidence: 99%

The potential of caffeine contained in the coffee to modulate the immune system of the COVID-19 sufferers: A review

Anis Irmawati,

Mochamad Daffa Athallah,

Retno Indrawati Roestamadji

et al. 2023

World J. Adv. Res. Rev.

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“…(Assa et al 2021).i Gambar 1. Diameter zona hambat yang terbentuk pada ekstrak biji kopi hijau terhadap Propionibacterium acne Gambar 2.…”

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Uji Ekstrak Biji Kopi Hijau (Coffea canephora var. robusta) terhadap Bakteri Propionibacterium acnes dan Staphyolococcus aureus Secara Difusi

Nurhayati¹,

Septiarini²,

Aisyah³

2023

PPTK

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Jerawat merupakan salah satu penyakit kulit paling umum ditemukan di semua usia yang salah satu penyebabnya adalah infeksi bakteri Staphylococcus aureus. Kopi dapat menjadi alternatif lain untuk mengatasi resistensi antibiotik karena memiliki senyawa antibakter Penelitian ini bertujuan untuk menentukan konsentrasi ekstrak biji hijau kopi robusta yang paling optimal sebagai antibakteri P. acne dan S.aureus. Ekstraksi biji hijau kopi robusta dilakukan dengan metode maserasi menggunakan pelarut etanol 96%, pengujian antibakteri dari biji hijau kopi robusta dilakukan dengan metode difusi agar untuk menentukan LDH dengan konsentrasi 1,56%, 3,125%, 6,25%, 12,5%, 25%, dan 50%. Kontrol positif menggunakan Ciprofloxacin 5 ppm dan kontrol negatif menggunakan DMSO 1%. Hasil penelitian menunjukan ekstrak biji hijau kopi robusta paling efektif terhadap S.aureus didapatkan pada konsentrasi 50%, yaitu dengan lebar daya hambat paling besar 33,1±0,05 mm. Sedangkan terhadap P. acne, ekstrak biji hijau kopi robusta paling efektif dengan konsentrasi 50% dengan lebar daya hambat sebesar 30,4±0,35 mm. Disimpulkan bahwa biji kopi hijau berpotensi untuk dimanfaatkan sebagai alternatif bahan antijerawat.

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Potensi Senyawa Aktif Biji Kopi sebagai Imunomodulator (Ulasan)

Cited by 2 publications

References 21 publications

The potential of caffeine contained in the coffee to modulate the immune system of the COVID-19 sufferers: A review

The potential of caffeine contained in the coffee to modulate the immune system of the COVID-19 sufferers: A review

Uji Ekstrak Biji Kopi Hijau (Coffea canephora var. robusta) terhadap Bakteri Propionibacterium acnes dan Staphyolococcus aureus Secara Difusi

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