Potency of pre–post treatment of coenzyme Q10 and melatonin supplement in ameliorating the impaired fatty acid profile in rodent model of autism

Abstract

BackgroundAbnormalities in fatty acid metabolism and membrane fatty acid composition play a part in a wide range of neurodevelopmental and psychiatric disorders. Altered fatty acid homeostasis as a result of insufficient dietary supplementation, genetic defects, the function of enzymes involved in their metabolism, or mitochondrial dysfunction contributes to the development of autism.ObjectiveThis study evaluates the association of altered brain lipid composition and neurotoxicity related to autism spectrum disorders in propionic acid (PA)–treated rats.DesignForty-eight young male western albino rats were used in this study. They were grouped into six equal groups with eight rats in each. The first group received only phosphate buffered saline (control group). The second group received a neurotoxic dose of buffered PA (250 mg/kg body weight/day for 3 consecutive days). The third and fourth groups were intoxicated with PA as described above followed by treatment with either coenzyme Q (4.5 mg/kg body weight) or melatonin (10 mg/kg body weight) for 1 week (therapeutically treated groups). The fifth and sixth groups were administered both compounds for 1 week prior to PA (protected groups). Methyl esters of fatty acid were extracted with hexane, and the fatty acid composition of the extract was analyzed on a gas chromatography.ResultsThe obtained data proved that fatty acids are altered in brain tissue of PA-treated rats. All saturated fatty acids were increased while all unsaturated fatty acids were significantly decreased in the PA-treated group and relatively ameliorated in the pre–post melatonin and coenzyme Q groups.ConclusionsMelatonin and coenzyme Q were effective in restoring normal level of most of the impaired fatty acids in PA-intoxicated rats which could help suggest both as supplements to ameliorate the autistic features induced in rat pups.

Efficacy of Novavit in ameliorating the neurotoxicity of propionic acid

“…The finding of the current study is of great support to our previous work in which vitamin D, CoQ10, vitamin B12, carnitine, and bioflavonoids (as major components of bee pollen) demonstrate significant potency in ameliorating PPA-induced persistent autistic features in the rodent model [ 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ].…”

The Possible Protective Effect of Melatonin and Coenzyme Q10 on Lung Injury Induced by Bleomycin in Adult Male Albino Rats

“…Also, Elbaky et al (31) stated that CoQ10 and N-Acetylcysteine had an ameliorative role in myocardial oxidative stress and encourages their use in protection from cardiotoxicity. El-Ansary et al proved the role of melatonin and co enzyme Q10 in ameliorating the impaired fatty acid profile in rodent model of autism (32) . Conclusion: melatonin had a higher protective effect than co enzyme Q10 in elimination the injury effect of bleomycin in lung tissue.…”

Investigating the influence of ubiquinone blood level on the abilities of children with specific learning disorder

“…The ubiquinone is an antioxidant that has a neuroprotective value [ 23 ]. It has a protective role on polyunsaturated fatty acids which constitute an important component of neurons and myelin sheath [ 24 ]. The learning disorder participants manifested less ubiquinone levels in relation to controls which could indicate oxidative stress.…”