Potency Equivalency Factors for Some Polycyclic Aromatic Hydrocarbons and Polycyclic Aromatic Hydrocarbon Derivatives

Mutagenic and Carcinogenic Hazards of Settled House Dust I: Polycyclic Aromatic Hydrocarbon Content and Excess Lifetime Cancer Risk from Preschool Exposure

“…The PEFs were BaA ) 0.1, BbF ) 0.1, BkF ) 0.1, CHRY ) 0.001, I123cdP ) 0.1, DBahA ) 5. All PEFs were taken from Collins et al (32), except for DbahA, which was taken from Nisbet and Lagoy (33). IR ) Daily ingestion rate of dust (g day -1 ).…”

Calculated respiratory exposure to indoor size-fractioned polycyclic aromatic hydrocarbons in an urban environment

“…Several approaches based on atmospheric PAH levels have been developed to evaluate the carcinogenic potency of the components in mixtures of PAHs (Collins et al, 1998;Nisbet and LaGoy, 1992). One of the most widely used methods involves toxicity equivalency factors (TEFs; Table 1) based on benzo(a)pyrene (Nisbet and LaGoy, 1992).…”

Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air

“…In a criteria document issued by the California EPA (CARB 1994), TEF values were developed for PAHs and PAH derivatives known to be carcinogenic in animals (see also Collins et al 1998). For most of these chemicals, data on mouse skin carcinogenesis were used to compare the cancer activity relative to B[a]P. For some compounds, data were also available from experiments using intrapulmonary administration to rats and tests for lung adenomas in newborn mice.…”