Potency control of foot-and-mouth disease vaccine in cattle. Comparison of the 50% protective dose and the protection against generalization

Filho, Y L Vianna; Astudillo, V.; Gomes, I.; Fernandez, G.; Rozas, César Eduardo Enriquez; Ravison, J.A.; Alonso, A.

doi:10.1016/0264-410x(93)90171-s

Cited by 27 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each vaccine component was formulated >6PD 50 by the vaccine manufacturer (equivalent to >90%PPG [26] ), although this experiment did not use homologous challenge to specifically confirm this. The vaccine potency was assessed by using pre-existing serological correlates for each of the components with expected potency at the point of market authorisation.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage

Waters

Ludi

Fowler

et al. 2018

Vaccine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage

Waters

Ludi

Fowler

et al. 2018

Vaccine

View full text Add to dashboard Cite

show abstract

“…The PPG method, currently used in Latin America, has proved to be highly reliable (Filho et al, 1993). In this test, vaccine potency is tested in a group of cattle in which 16 animals are vaccinated and two remain as unvaccinated controls.…”

Section: Introductionmentioning

confidence: 99%

“…Protection against podal generalization (PPG) and 50% protective dose (PD 50 ) are direct methods commonly in use (OIE, 2009). The PPG method, currently used in Latin America, has proved to be highly reliable (Filho et al., 1993). In this test, vaccine potency is tested in a group of cattle in which 16 animals are vaccinated and two remain as unvaccinated controls.…”

Section: Introductionmentioning

confidence: 99%

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

Gnazzo

Quattrocchi

Soria

et al. 2020

Transbound. Emerg. Dis.

View full text Add to dashboard Cite

Foot-and-mouth disease virus (FMDV) is a picornavirus belonging to the Aphthovirus genus (Soria et al., 2017). FMDV has seven distinct serotypes, namely O, A, C, SAT1, SAT2, SAT3 and Asia 1. This virus produces foot-and-mouth disease (FMD), a devastating and highly transmissible infection of farm animals, with large associated economic losses. Some countries are either FMD free or close to achieving eradication, while others are at an early stage of FMD control. In many countries, FMD control is performed by regular vaccination based on inactivated whole virus (Soria et al., 2017).

show abstract

“…For vaccination in naïve populations to control FMD outbreaks, higher potency vaccines (e.g. >6 PD 50 for the duration of the shelf life claimed by the manufacturer) are recommended for their wider spectrum of immunity as well as their rapid onset of protection [30,31,32,33,34]. According to the PD 50 results of the GRI vaccine (which was manufactured at the Nuclear Science and Technology Research Institute of Iran) and the conventional vaccine (which was manufactured in the Razi Vaccine and Serum Research Institute of Iran), both deliver more than 6 PD 50 , so these vaccines are suitable for both routine vaccination and control of FMDV outbreaks in naïve calves.…”

Section: Discussionmentioning

confidence: 99%

Development of Protective Immunity against Inactivated Iranian Isolate of Foot-and-Mouth Disease Virus Type O/IRN/2007 Using Gamma Ray-Irradiated Vaccine on BALB/c Mice and Guinea Pigs

Motamedi-Sedeh

Soleimanjahi²,

Jalilian³

et al. 2015

Intervirology

View full text Add to dashboard Cite

Objectives: Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals and is the most damaging disease of livestock worldwide, leading to great economic losses. The aim of this research was the inactivation of FMDV type O/IRN/1/2007 to produce a gamma ray-irradiated (GRI) vaccine in order to immunize mice and guinea pigs. Methods: In this research, the Iranian isolated FMDV type O/IRN/1/2007 was irradiated by gamma ray to prepare an inactivated whole virus antigen and formulated as a GRI vaccine with unaltered antigenic characteristics. Immune responses against this vaccine were evaluated on mice and guinea pigs. Results: The comparison of the immune responses between the GRI vaccine and conventional vaccine did not show any significant difference in neutralizing antibody titer, memory spleen T lymphocytes or IFN-γ, IL-4, IL-2 and IL-10 concentrations (p > 0.05). In contrast, there were significant differences in all of the evaluated immune factors between the two vaccinated groups of mice and negative control mice (p < 0.05). The protective dose 50 for the conventional and GRI vaccines obtained were 6.28 and 7.07, respectively, which indicated the high potency of both vaccines. Conclusion: GRI vaccine is suitable for both routine vaccination and control of FMDV in emergency outbreaks.

show abstract

Potency control of foot-and-mouth disease vaccine in cattle. Comparison of the 50% protective dose and the protection against generalization

Cited by 27 publications

References 6 publications

Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage

Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

Development of Protective Immunity against Inactivated Iranian Isolate of Foot-and-Mouth Disease Virus Type O/IRN/2007 Using Gamma Ray-Irradiated Vaccine on BALB/c Mice and Guinea Pigs

Contact Info

Product

Resources

About