Potenciais evocados auditivos corticais em neonatos nascidos a termo e pré-termo

Melo, Ândrea de; Biaggio, Eliara Pinto Vieira; Rechia, Inaê Costa; Sleifer, Pricila

doi:10.1590/2317-1782/20162015291

Cited by 10 publications

(11 citation statements)

References 18 publications

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“…In this study, we did not use a control group; however, when observing the P1-N1-P2-N2 complex mean amplitude on children without auditory complaints evidenced by Agostinho-Pesse and Alvarenga (21), we noticed higher amplitudes. The amplitude can be related to the amount of neural structure that participates in the response, being proportional to the synaptic activation magnitude (22,23).…”

Section: Discussionmentioning

confidence: 99%

Peripheral and Central Auditory Findings in Individuals with Williams Syndrome

Fraga

Sleifer

Rosa

et al. 2019

JHSCI

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Introduction: Williams syndrome (WS) is a rare neurodevelopment genetic condition. The syndrome may present manifestations associated with the central nervous system, hearing, and language. It is possible, as well, to observe an alteration in the central auditory system, which can be diagnosed through long-latency auditory evoked potential (LLAEP). Objective: The aim of this study was to describe and analyze the results obtained by peripheral and central auditory evaluation on individuals with WS, verifying if there is a relationship between audiological findings and gender, age and ear side. Methods: This is a cross-sectional study in which 14 individuals with WS were evaluated. The exams performed consisted of pure tone audiometry, vocal audiometry, acoustic immittance measures, LLAEP, and cognitive potential. Results: The sample was composed of patients from 4 to 18 years old, with a mean age of 11.6 years old (±5.3), being 9 males (64.3%) and 5 females (35.7%). We mainly verified mild to moderate degree (40-44%) of sensorineural auditory loss (35.7-42.9%), type A tympanometric curve (57.1-64.3%), and absent acoustic reflexes (57.1%). As for central auditory evaluation, the subjects showed latency delay in all of the LLAEP components. Moreover, it was evidenced a statistically significant difference when comparing ears for amplitude on cognitive potential evaluation (p = 0.032), observing higher values at the left ear. It was also observed an inverse association between age and P1 wave latency both on the right (p = 0.006) and on the left ear (p = 0.022), and this result can be related to the nervous system maturational process of the WS individuals. Conclusion: There are few studies investigating the central auditory pathway on WS in literature. The present study contributes to the extension of the knowledge about the central involvement of the auditory phenotype in the syndrome. However, considering the sample size, more studies are suggested to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Peripheral and Central Auditory Findings in Individuals with Williams Syndrome

Fraga

Sleifer

Rosa

et al. 2019

JHSCI

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“…Some authors point out that the amplitude of the response relates directly to the amount of neural structure involved in the reply, being proportional to the magnitude of synaptic activation (Melo, Biaggio, et al, ; Sleifer, ). A relation between age and responses in latency and amplitude is also verified in humans.…”

Section: Discussionmentioning

confidence: 99%

“…However, in our literature review, we did not find studies comparing potential responses with attention, memory, and discrimination tests. These tests complement are objective and non‐invasive and complement the routine diagnostic evaluations for auditory changes (Junqueira & Colafêmina, ; Melo, Biaggio, Rechia, & Sleifer, ; Melo, Sleifer, Rechia, & Biaggio, ).…”

Section: Introductionmentioning

confidence: 96%

“…The long‐latency auditory evoked potentials assessment also allows for measurement or observation of the function of the peripheral and central auditory pathway. This may have paramount importance to the complementary evaluation, targeting adequate diagnosis closure, and/or understanding of auditory status, especially when the individuals have difficulty responding in subjective audiological tests; for example, when they need to indicate that they are listening to the stimulus (Melo, Biaggio, et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Auditory evoked potentials in children and adolescents with Down syndrome

Gregory

Rosa

Zen

et al. 2017

American J of Med Genetics Pt A

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Down syndrome, or trisomy 21, is the most common genetic alteration in humans. The syndrome presents with several features, including hearing loss and changes in the central nervous system, which may affect language development in children and lead to school difficulties. The present study aimed to investigate group differences in the central auditory system by long-latency auditory evoked potentials and cognitivepotential. An assessment of 23 children and adolescents with Down syndrome was performed, and a control group composed of 43 children and adolescents without genetic and/or neurological changes was used for comparison. All children underwent evaluation with pure tone and vocal audiometry, acoustic immitance measures, longlatency auditory evoked potentials, and cognitive potential. Longer latencies of the waves were found in the Down syndrome group than the control group, without significant differences in amplitude, suggesting that individuals with Down syndrome have difficulty in discrimination and auditory memory. It is, therefore, important to stimulate and monitor these children in order to enable adequate development and improve their life quality. We also emphasize the importance of the application of auditory evoked potentials in clinical practice, in order to contribute to the early diagnosis of hearing alterations and the development of more research in this area.central auditory evaluation, Down syndrome, electrophysiology, event-related potentials, evoked potentials, hearing, trisomy 21

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“…Both the amplitude and latency of these components change during maturation of auditory cortical circuits. The earliest components are called P1 and N1 and are already present in newborns (Cunningham, Nicol, Zecker, & Kraus, 2000;Melo, Biaggio, Rechia, & Sleifer, 2016). Latency of the P1 component shows a steady decrease until it stabilizes in adulthood (D. R. Moore, 2002;Valerie L Shafer, Yan, & Datta, 2011;V.…”

Section: Introductionmentioning

confidence: 99%

Early Exposure to Environment Sounds and the Development of Cortical Auditory Evoked Potentials of Preterm Infants During the First Three Months of Life

Cavalcanti

Nunes

Cunha

et al. 2020

Preprint

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ObjectivePrenatal experience influences the course of development of sensory pathways. Preterm infants are exposed earlier than their term counterparts to unattenuated sounds from the external environment during the sensitive period of organization of auditory cortical circuitry. In the current study, we evaluated how gestational age (GA) correlates with the latency of the P1 component of the cortical auditory evoked potential of two experimental groups measured at one or three months of age. Our sample consisted of 23 infants delivered at GA ranging from 31.28-41.42 weeks and separated into two groups evaluated transversally at one or three months of corrected age (CA).ResultsIn the group evaluated at one-month CA, the latency of the component P1 was similar in both term and late-preterm infants (GA>32 weeks). However, in the group evaluated at three months CA, P1 latency was significant smaller in preterms. These preliminary results suggest an acceleration of the development of auditory cortical pathways in preterms, probably due to their early exposure to socially relevant auditory stimuli from the external environment.Keywords: preterm, newborn, brain development, auditory, cortex

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Potenciais evocados auditivos corticais em neonatos nascidos a termo e pré-termo

Cited by 10 publications

References 18 publications

Peripheral and Central Auditory Findings in Individuals with Williams Syndrome

Peripheral and Central Auditory Findings in Individuals with Williams Syndrome

Auditory evoked potentials in children and adolescents with Down syndrome

Early Exposure to Environment Sounds and the Development of Cortical Auditory Evoked Potentials of Preterm Infants During the First Three Months of Life

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