Potassium iodide in dermatology

Hassan, Iffat; Keen, Abid

doi:10.4103/0378-6323.95472

Cited by 22 publications

(22 citation statements)

References 32 publications

(35 reference statements)

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“…A recent report has described excessive inflammatory cytokine production, mainly by IL‐1, in ND and the efficacy of IL‐1‐blocking therapies. Another study demonstrated the production of IL‐1 and TNF by adherent peritoneal cells in BALB/c mice after intravenous inoculation with Sporothrix schenckii , which is known to respond to KI . Another study revealed that nicotine augmented macrophage release of IL‐1 β and TNF‐ α .…”

Section: Discussionmentioning

confidence: 99%

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Palmoplantar pustulosis and pustulotic arthro‐osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients

et al. 2017

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Section: Discussionmentioning

confidence: 99%

“…Although PPP is not classified by researchers as ND, we propose that this may be involved in the pathogenesis of both ND and PPP. KI inhibits generation of neutrophil‐derived oxygen intermediates and neutrophil chemotaxis in peripheral blood . These effects can probably affect both ND and PPP.…”

Section: Discussionmentioning

confidence: 99%

Palmoplantar pustulosis and pustulotic arthro‐osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients

et al. 2017

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“…SSKI mixed with another liquid prevents gastrointestinal irritation. SSKI is absorbed after oral administration, acts directly on the thyroid gland, and excreted primarily in the urine …”

Section: Discussionmentioning

confidence: 99%

Potassium iodide in refractory, recurrent pediatric Sweet syndrome: Guidance in dosing and monitoring

Tangtatco

Drucker

et al. 2018

Pediatric Dermatology

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We describe a 5-month-old boy with clinical and histopathologic presentation of Sweet syndrome. He responded to systemic corticosteroids, with multiple flares on tapering; potassium iodide was added, which provided complete resolution of Sweet syndrome. Potassium iodide has been used in only a few cases, and no standard dosage has been established in children. We discuss calculation of a pediatric dosage for potassium iodide in Sweet syndrome.

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“…KI is effective against localized form of infections of some selective low virulence microbes only and paradoxically poorly effective against their systemic infections. [2] Human volunteer study by Rex and Bennett (1990)[7] disproved role of enhanced phagocytosis by KI-treated macrophages and pointed towards need of a realistic hypothesis, because all previous hypothesis indicates wide-spectrum anti-microbial action of KI, which is not true and fail to explain why such action is of very selective in nature, particularly in diseases with Splendore-Hoeppli phenomenon e.g., sporotrichosis, actinomycosis, entomophthoramycosis, chromoblastomycosis, and some mycetomas. [8]…”

Section: Discussionmentioning

confidence: 99%

“…[2] Oral KI therapy is found to affect specific lysis of those fungi in tissues having histological hallmarks of some eosinophilic immune deposit around them in the form of Splendore-Hoeppli (SH) bodies. It also alters course of lepra reaction and some type III immune complex diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of potassium iodide on low avid immunological reactions: Probable mechanism of action on selective fungal infections

Maiti¹,

Das²,

Ghosh³

et al. 2013

Ann Med Health Sci Res

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Background:Selective in-vivo anti-fungal action of potassium iodide (KI) is an enigma, but circumstantial evidences strongly indicate some immune mechanism.Aim:Study was to demonstrate in-vitro immune-modulating role of KI.Materials and Methods:In identical test conditions keeping appropriate control, different immunological tests were performed with and without 0.1% effective concentration of KI. i) Sera from Coombs positive mothers were treated with O, Rh-positive erythrocyte suspensions along with Coombs’ sera (CS)/Bovine albumin (BA)/KI. ii) Amboceptor and complement (C) mixtures were titrated for hemolysis with or without KI. iii) Suspension of Salmonella Typhi with positive sera from enteric cases and C + KI was incubated at 37°C for 30 minutes, then sub-cultured on MacConkey Agar. iv) Positive serum from chronic muco-cutaneous candidiasis patient was treated with suspension of candida isolate and C + KI at 37°C for 30 minutes then sub-cultured to note variations in colony counts. The data was analyzed by Fishers exact test using Graphpad Prism 5 version 5.00 (California USA)Results:i) KI like BA or CS showed hemagglutination. ii) C-mediated hemolysis was inhibited in presence of KI. iii) C-mediated lysis of S. typhi was partially enhanced by KI showing reduced number of colonies; iv) while lysis of candida was reduced.Conclusions:KI increases avidity of some immune reactions including C-mediated cell lysis. An increase or decrease of cell-lysis resulted by KI probably mediates by altered access of C-binding receptors. Thus, hypothetically, a non-protective Splendore Hoeppli-like deposit around fungus may turn into protective immune mechanism by influence of KI.

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Potassium iodide in dermatology

Cited by 22 publications

References 32 publications

Palmoplantar pustulosis and pustulotic arthro‐osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients

Palmoplantar pustulosis and pustulotic arthro‐osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients

Potassium iodide in refractory, recurrent pediatric Sweet syndrome: Guidance in dosing and monitoring

Effects of potassium iodide on low avid immunological reactions: Probable mechanism of action on selective fungal infections

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