Potassium-Escape-Phenomenon in Rats during Continuous Application of Amiloride

Abstract

In normal and adrenalectomized rats the potassium-escape-phenomenon during continuous amiloride treatment was studied after pretreatment with diets of different potassium content. (1) The period of potassium retention during amiloride application was shortened when the rats were pretreated with the diet of elevated potassium content. (2) The potassium-escape-phenomenon was not significantly modified in adrenalectomized rats.

Site and mechanism of the action of diuretics

“…During long-term treatment with amiloridc there may be an "cscape" from the potassium-sparing effect which. however, is maintained if the negative potassium balance persists (Hohenegger 1973).…”