Potassium channel conductance as a control mechanism in hair follicles

Buhl, Allen E.; Conrad, Steven J.; Waldon, Daniel J.; Brunden, Marshall N.

doi:10.1016/0022-202x(93)90517-l

Cited by 29 publications

(17 citation statements)

References 25 publications

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“…Potassium channel openers promote hair growth by a direct effect on hair follicles, and by improving blood supply to follicles [150,151]. In particular minoxidil stimulates DNA synthesis in epidermal keratinocytes and whole-hair follicles enhancing proliferation and differentiation of the epithelial hair shaft and increase hair density by induction of anagen or an increase in anagen duration.…”

Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

“…In particular minoxidil stimulates DNA synthesis in epidermal keratinocytes and whole-hair follicles enhancing proliferation and differentiation of the epithelial hair shaft and increase hair density by induction of anagen or an increase in anagen duration. [150,151]. Topical minoxidil maintain and stimulate new hair growth and helps stop the loss of hair in men with androgenic alopecia and women with female pattern hair loss [150][151][152][153].…”

Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

“…[150,151]. Topical minoxidil maintain and stimulate new hair growth and helps stop the loss of hair in men with androgenic alopecia and women with female pattern hair loss [150][151][152][153]. The increase in hair growth, measured by hair counts or hair weight is evident within 6-8 weeks of starting treatment and generally peaks by 12-16 weeks [153].…”

Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

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K channel therapeutics at the bedside

Jahangir

Terzic

2005

Journal of Molecular and Cellular Cardiology

131

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The family of potassium channel openers regroups drugs that share the property of activating adenosine triphosphate-sensitive potassium (K(ATP)) channels, metabolic sensors responsible for adjusting membrane potential-dependent functions to match cellular energetic demands. K(ATP) channels, widely represented in metabolically-active tissue, are heteromultimers composed of an inwardly rectifying potassium channel pore and a regulatory sulfonylurea receptor subunit, the site of action of potassium channel opening drugs that promote channel activity by antagonizing ATP-induced pore inhibition. The activity of K(ATP) channels is critical in the cardiovascular adaptive response to stress, maintenance of neuronal electrical stability, and hormonal homeostasis. Thereby, K(ATP) channel openers have a unique therapeutic spectrum, ranging from applications in myopreservation and vasodilatation in patients with heart or vascular disease to potential clinical use as bronchodilators, bladder relaxants, islet cell protector, antiepileptics and promoters of hair growth. While the current experience in practice with potassium channel openers remains limited, multitude of ongoing investigations aims at defining the benefit of this emerging family of therapeutics in diverse disease conditions associated with metabolic distress.

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Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

Section: Potassium Channel Openers Use In Dermatologymentioning

confidence: 99%

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K channel therapeutics at the bedside

Jahangir

Terzic

2005

Journal of Molecular and Cellular Cardiology

131

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“…Androgenic alopecia (AGA) is a common form of hair loss (HL), affecting men and women at different ages [1,2]. In AGA, androgens are involved in the reduction of anagen phase, inducing an increment of the number of hair follicles (HF) in the catagen and telogen phases as well as delaying the telogen-to-anagen transition [3].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…Minoxidil은 체내에서 sulpho-transferase의 촉매작용으로 빠르게 Minoxidil sulphate로 전환됨으로서 vascular smooth muscle의 빠른 이 완작용을 유발하여 혈압강하의 효과를 유발한다고 보고되 었다 [3]. Minoxidil 이외에 다른 potassium channel opener 를 대상으로 한 발모실험 [4]에서 Cromakalin 및 P-1075 (Pinacidil analog)도 발모효과가 입증되어 potassium channel 이 발모효과의 중요한 표적으로 인식되었다. 그러나 근래에 Minoxidil에 대한 연구가 다양하게 이루어지면서 potassium channel opener 뿐만 아니라, 세포기능에 다양한 효과를 보 인다고 밝혀졌다.…”

Section: 서론unclassified

Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

Myung¹,

Sung²,

Lee³

2012

KSBB Journal

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1) In order to explore structural features of minoxidil analogs with a view of enhancing lysyl hydroxylase (LH) inhibitory activity, molecular holographic QSAR (HQSAR) and CoMSIA (comparative molecular similarity indices analysis) were performed. The results from the atomic contributions with optimized the HQSAR 6-2 model indicated that, in case of pyrimidine-1-N-oxide substituent, C2 atom of pyrimidine ring and C'3-C'4 bond of 4-piperidinol group showed the highest impact on the inhibitory activity towards LH enzyme. It was also evident from the information of the optimized CoMSIA F5 model that the inhibitory activity mainly depended on the hydrophobic field contribution (36%) and the hydrogen bond (H-bond) field contribution (49.2%) of substrate molecule. Particularly, it is predicted that the functional groups which disfavor H-bond acceptors in large space around the piperidinol group and also the functional groups which favor the H-bond acceptors at C'4 (& C'5) atom

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Potassium channel conductance as a control mechanism in hair follicles

Cited by 29 publications

References 25 publications

K channel therapeutics at the bedside

K channel therapeutics at the bedside

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

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