Objectives. It is generally accepted that large breast sizes among women contribute to the development of back pain and poor posture. The aim of our research was to determine if the hypothesis that the size of the breasts has an impact on the pain of the musculoskeletal system in women, can be confirmed or denied on the basis of available literature. Material and methods. A systematic review based on the contents of the PubMed database, ResearchGate, ScienceDirect, and Google Scholar databases was performed. In order to identify relevant publications, a search using a combination of key words "breast size", "spine pain" and "musculoskeletal pain"(according to Medical Subject Headings-MeSH) was performed. Four studies have been included in our review. Results. The correlation between breast size and pain is confirmed by three studies. One study stands in opposition to the others. Considering the value of evidence and results in peer-reviewed publications, we conclude that there is considerable evidence to support the hypothesis that the size of the breasts affects the painfulness of the musculoskeletal system. Conclusions. Due to the small amount of available literature, we find that studies on the impact of bust size on pain of the musculoskeletal system should be continued on a larger scale. Based on the above review, we conclude that there is considerable evidence to support the hypothesis that the size of the breasts affects the painfulness of the musculoskeletal system.