Posttreatment Evaluation of Brain Gliomas

Dalesandro, Mark F.; Andre, Jalal B.

doi:10.1016/j.nic.2016.06.007

Cited by 18 publications

(8 citation statements)

References 74 publications

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“…Another challenge is pseudo-progression, which makes imaging unreliable during the first 12 weeks after radiotherapy. [4][5][6][7] Cisplatin exerts a strong cytotoxic effect on glioma cells. [8][9][10] However, due to the limited penetration of the blood-brain barrier it is difficult to administer cisplatin systemically in relevant doses without dose-limiting neuro-or nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

et al. 2019

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BACKGROUND: High-grade gliomas are associated with poor prognosis. Tumour heterogeneity and invasiveness create challenges for effective treatment and use of systemically administrated drugs. Furthermore, lack of functional predictive response-assays based on drug efficacy complicates evaluation of early treatment responses. METHODS: We used microdialysis to deliver cisplatin into the tumour and to monitor levels of metabolic compounds present in the tumour and non-malignant brain tissue adjacent to tumour, before and during treatment. In parallel, we collected serum samples and used multivariate statistics to analyse the metabolic effects. RESULTS: We found distinct metabolic patterns in the extracellular fluids from tumour compared to non-malignant brain tissue, including high concentrations of a wide range of amino acids, amino acid derivatives and reduced levels of monosaccharides and purine nucleosides. We found that locoregional cisplatin delivery had a strong metabolic effect at the tumour site, resulting in substantial release of glutamic acid, phosphate, and spermidine and a reduction of cysteine levels. In addition, patients with longtime survival displayed different treatment response patterns in both tumour and serum. Longer survival was associated with low tumour levels of lactic acid, glyceric acid, ketoses, creatinine and cysteine. Patients with longer survival displayed lower serum levels of ketohexoses, fatty acid methyl esters, glycerol-3-phosphate and alpha-tocopherol, while elevated phosphate levels were seen in both tumour and serum during treatment. CONCLUSION: We highlight distinct metabolic patterns associated with high-grade tumour metabolism, and responses to cytotoxic cisplatin treatment.

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Section: Introductionmentioning

confidence: 99%

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

et al. 2019

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“…Кроме того, измерение опухоли на основе одного только контрастного усиления оказалось менее надежным, особенно при одновременном применении темозоломида (ТМЗ) с облучением, что может привести к псевдопрогрессии (ПсП) у некоторых пациентов. Точная оценка опухолевого ответа на основе усиления заболеваниясложная задача в контексте лучевого некроза, а также после изменения дозы КС или применения антиангиогенных агентов, таких как бевацизумаб: они нарушают гематоэнцефалический барьер, снижают контрастирование, что вызывает псевдоответ [35].…”

Section: критерии оценки эффективности лечения глиомunclassified

“…полагают: широкое использование перфузионной визуализации для дифференцирования лучевого некроза и рецидива осложняется тем, что существуют различные методы изучения «перфузии», со множеством параметров визуализации и методик постобработки. В связи с этим возникает неоднородность наблюдений, она значительно затрудняет интерпретацию данных [35].…”

Section: Russian Journal Of Neurosurgeryunclassified

High-grade gliomas: a literature review. Part 2. Radiosurgical treatment

Gretskikh

Токарев

2022

Nejrohirurgiâ (Mosk.)

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Malignant brain tumors remain one of the most complex problem in modern oncology, being among the most dangerous types of cancer not only because of their poor prognosis, but also due to the immediate consequences for quality of life and cognitive functions. It is expected that the number of such patients will increase as the life expectancy of the population increases.The mortality rate of patients with malignant gliomas remains the highest among all cancer patients. The median survival rate in this population does not exceed 24.5 months. Despite serious progress in the study of the molecular biology of this type of tumor, the question of effective application of this knowledge in the treatment process remains open.The review highlights the most advanced diagnostic methods and analyzes the effectiveness of a multidisciplinary therapeutic strategy. Special attention is given to the search for new approaches to radiosurgical treatment of high-grade gliomas in order to increase the duration and improve the quality of life of patients. The literature review is divided into 2 parts. Part 1 covers the epidemiology, clinic, and diagnosis of high-grade gliomas, as well as a combined approach to the treatment of the disease. In the 2nd part, the issues of stereotactic radiosurgery of high-grade gliomas, the features of the practical application of the “gamma knife” device in this pathology are highlighted; the effectiveness of the multimodal approach to the treatment of malignant gliomas is analyzed.

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“…Оставшаяся рядом инфильтрированная опухолевыми клетками мозговая ткань обрабатывается комбинацией ЛТ и ХТ [74,81]. Стандартным режимом послеоперационной терапии для пациентов с впервые диагностированной глиобластомой в хорошем общем состоянии является ЛТ в сочетании с ежедневным приемом темозоломида в дозе 75 мг / м 2 с последующим интервалом примерно 4 нед без терапии и дальнейшим проведением до 6 циклов терапии темозоломидом в дозе 150-200 мг / м 2 в течение 5 дней (цикл длительностью 28 дней) [60,83].…”

Section: лучевая терапияunclassified

“…По мнению ряда авторов, риск развития радиационно-ассоциированных вторичных злокачественных новообразований через 20 лет после облучения ЦНС составляет 1-3 %; обычно это наблюдается у тех, кто прошел ЛТ в детском или молодом возрасте [83].…”

Section: Russian Journal Of Neurosurgeryunclassified

High-grade gliomas: a literature review. Part 1. Epidemiology, classification and approaches to combination treatment

Gretskikh

Токарев

2021

Nejrohirurgiâ (Mosk.)

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Malignant brain tumors remain one of the most complex problem in modern oncology, being among the most dangerous types of cancer not only because of their poor prognosis, but also due to the immediate consequences for quality of life and cognitive functions. It is expected that the number of such patients will increase as the life expectancy of the population increases.The mortality rate of patients with malignant gliomas remains the highest among all cancer patients. The median survival rate in this population does not exceed 24.5 months. Despite serious progress in the study of the molecular biology of this type of tumor, the question of effective application of this knowledge in the treatment process remains open.The review highlights the most advanced diagnostic methods and analyzes the effectiveness of a multidisciplinary therapeutic strategy. Special attention is given to the search for new approaches to radiosurgical treatment of highgrade gliomas in order to increase the duration and improve the quality of life of patients.The literature review is divided into 2 parts. Part 1 covers the epidemiology, clinic, and diagnosis of high-grade gliomas, as well as a combined approach to the treatment of the disease.

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Posttreatment Evaluation of Brain Gliomas

Cited by 18 publications

References 74 publications

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma

High-grade gliomas: a literature review. Part 2. Radiosurgical treatment

High-grade gliomas: a literature review. Part 1. Epidemiology, classification and approaches to combination treatment

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