Posttraumatic stress disorder in children affected by sickle‐cell disease and their parents

Hofmann, Michel; Montalembert, Mariane de; Beauquier-Maccotta, Bérengère; Villartay, Philippe de; Golse, Bernard

doi:10.1002/ajh.20722

Cited by 24 publications

(23 citation statements)

References 8 publications

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“…Several studies found that 30-40% of the caregivers had symptoms of psychological distress. [10][11][12][13] These studies were descriptive and did not compare caregivers of SCD patients to a control group of parents with healthy children. In order to conclude that psychological distress is related to caring for children with SCD, a well-matched control group is essential.…”

Section: Introductionmentioning

confidence: 99%

Quality of life of female caregivers of children with sickle cell disease: a survey

Tweel¹,

Hatzmann²,

Ensink³

et al. 2008

Haematologica

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Caring for a child with sickle cell disease poses extra demands on parents, both practically and psychologically, which may influence their quality of life. Since families of children with sickle cell disease in the Netherlands usually belong to immigrant communities with a low socio-economic status, there may be an additional strain on caregivers. The aim of the present study was to evaluate the quality of life of caregivers of children with sickle cell disease. The quality of life of female caregivers of sickle cell disease patients, measured with the TNO-AZL Adult Quality of Life questionnaire, was compared to the norm data of healthy Dutch females (n=700) and female caregivers of healthy children with the same socio-economic status and ethnic background (socio-economic status control group). Groups were compared by the Mann-Whitney U test. Point estimates and 95% confidence intervals of the median difference are presented. The results of questionnaires of 54 caregivers of children with sickle cell disease and 28 caregivers of a control group of the same socio-economic status were analyzed. Caregivers of patients with sickle cell disease had a significantly lower quality of life on all subscales compared to the Dutch norm population. Compared to the control group of the same socio-economic status, the quality of life of caregivers of patients with sickle cell disease was significantly lower on the subscales depressive moods, daily activities and vitality. In this first study reporting on the quality of life of caregivers of children with sickle cell disease, we demonstrate a reduced quality of life in these caregivers compared to the healthy Dutch female population and caregivers of healthy children with the same socio-economic status.Key words: sickle cell disease, quality of life, caregivers. Citation

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Section: Introductionmentioning

confidence: 99%

Quality of life of female caregivers of children with sickle cell disease: a survey

Tweel¹,

Hatzmann²,

Ensink³

et al. 2008

Haematologica

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“…5 Mutations in genes which regulate the response to hypoxia, such as VHL and PHD2 and HIF-2α have recently been found in a number of familial polycythemia syndromes with high serum erythropoietin levels. 6,7 Familial thrombocytosis without involvement of other lineages can be caused by mutations in THPO or MPL. Some families with elevated serum thrombopoietin levels carry activating mutations in the THPO gene which cause overproduction of the thrombopoietin protein by a mechanism of increased translational efficiency for the mutant THPO mRNA.…”

Section: Jak2-v617fmentioning

confidence: 99%

“…Families and patients may experience post-traumatic stress disorder, the rate of occurrence of which is not correlated with disease severity. 6 Thus, the disease itself, independently of the number of hospital admissions and complications, adversely affects the quality of life of the patients and their families. This quality-oflife burden is being increasingly recognized by physicians and families as a key component in the risk/benefit ratio of treatments for SCD.…”

mentioning

confidence: 99%

Sickle cell disease: primum non nocere (first do no harm)

Montalembert¹,

Roberts²

2010

Haematologica

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“…Identifying anxiety in adolescents with SCD imposes a high clinical relevance, because of the distress stemming from anxiety itself, which may disturb the child's development, and fear of recurrence that may worsen the consequences of vaso-occlusion, and promote inadequate use of analgesics (Hofmann et al 2007). …”

Section: Examined 84 Nigerianmentioning

confidence: 99%

Psychiatric Disorders in a Sample of Saudi Arabian Adolescents with Sickle Cell Disease

Amr

Amin

Hablas

2009

Child Youth Care Forum

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The objectives of this study were to determine the magnitude of psychiatric disorders and to define socio-demographic and disease-related risk factors in a sample of adolescents with SCD in Al-Hassa, Saudi Arabia. The sample consisted of 110 adolescents with SCD and a convenient sample of 202 adolescents without SCD as controls. Psychiatric assessment was based a double test strategy through employing the observation form of the semi-structured clinical interview for children and adolescents (SCICA), followed by clinical interview based on the Diagnostic and Statistical manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR 2000). The study revealed that 29.0% of adolescents with SCD and 32.0% of adolescents without SCD were screened positive for one or more psychiatric disorders. Adolescents with SCD showed higher prevalence of adjustment and anxiety disorders compared to their peers. Hierarchical logistic regression analysis for determination of the independent predictors of psychopathology among adolescents with SCD revealed that male gender and high family income were independent protective factors while frequent pain episodes served as an independent risk factor for the development of psychiatric morbidity. Psychiatric assessment using a semi-structured clinical interview in adolescents yields a comprehensive view of the adolescent psychopathology in SCD that calls for early identification and intervention.

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Posttraumatic stress disorder in children affected by sickle‐cell disease and their parents

Cited by 24 publications

References 8 publications

Quality of life of female caregivers of children with sickle cell disease: a survey

Quality of life of female caregivers of children with sickle cell disease: a survey

Sickle cell disease: primum non nocere (first do no harm)

Psychiatric Disorders in a Sample of Saudi Arabian Adolescents with Sickle Cell Disease

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