Posttraumatic lipogranuloma on the lower leg

Late-Onset Complication of Fillers: Paraffinoma of the Lower Eyelids Clinically Mimicking Xanthelasma

“…Its mechanism involves endogenous fat degeneration8. The breakdown of endogenous lipid following trauma, vascular insufficiency, infection, foreign body injection, and other such events results in the release of fat droplets into the intracellular spaces, and this leads to a macrophage response8. A lipogranulomatous reaction can occur through this process, and our case could be partly explained by this mechanism.…”

“…Although the exact pathomechanism of paraffinoma is still unknown, an inflammatory reactive process associated with exogenous or endogenous lipids in the dermis and subcutaneous layer is believed to be involved8. Paraffinoma typically occurs in areas where lipid material has entered traumatically or has been injected for a specific purpose.…”

“…This type of paraffinoma can be explained by the natural host response to wall off exogenous substances that are too large to be ingested by macrophages7. However, another type of paraffinoma that occurs after exenatide injection, triamcinolone injection, aluminum hydroxide injection, and trauma has been reported; however, this type cannot be explained by the above mechanism8910. Its mechanism involves endogenous fat degeneration8.…”

“…However, another type of paraffinoma that occurs after exenatide injection, triamcinolone injection, aluminum hydroxide injection, and trauma has been reported; however, this type cannot be explained by the above mechanism8910. Its mechanism involves endogenous fat degeneration8. The breakdown of endogenous lipid following trauma, vascular insufficiency, infection, foreign body injection, and other such events results in the release of fat droplets into the intracellular spaces, and this leads to a macrophage response8.…”