Posttransplantation Encephalopaties

Anghel, Daniela; Dumitrescu, Laura; Coclitu, Catalina; Ene, Amalia; Băjenaru, Ovidiu; Tanasescu, Radu

doi:10.5772/38927

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…Antiinflammatory drugs given immediately after SCI improved locomotor function in animal studies [58]. But, immune-suppressive drugs can be neurotoxic [59]. Our study avoided immune-suppressive agents.…”

Section: Discussionmentioning

confidence: 71%

Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury

et al. 2021

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Transplantation of neural progenitor cell (NPC) possessing the potential to differentiate into neurons may guard against spinal cord injury (SCI)- associated neuronal trauma. We propose that autologous-like NPC may reduce post-transplant immune response. The study used the rat SCI model to prove this concept. For isolation and expansion of rat NPC for cell-based SCI therapy, the in vitro protocol standardized with human NPC seemed suitable. The primary aim of this study is to select a cell/neural tissue-compatible biomaterial for improving NPC survival in vivo. The composition of the fibrin hydrogel is adjusted to obtain degradable, porous, and robust fibrin strands for supporting neural cell attachment, migration, and tissue regeneration. This study employed NPC culture to evaluate the cytocompatibility and suitability of the hydrogel, composed by adding graded concentrations of thrombin to a fixed fibrinogen concentration. The microstructure evaluation by scanning electron microscope guided the selection of a suitable composition for delivering the embedded cells. On adding more thrombin, fibrinogen clotted quickly but reduced porosity, pore size, and fiber strand thickness. The high activity of thrombin also affected NPC morphology and the in vitro cell survival. The selected hydrogel carried viable NPC and retained them at the injury site post-transplantation. The fibrin hydrogel played a protective role throughout the transfer process by providing cell attachment sites and survival signals. The fibrin and NPC together regulated the immune response at the SCI site reducing ED1+ve/ED2+ve macrophages in the early period of 8–16 d after injury. Migration of β-III tubulin+ve neural-like cells into the fibrin-injected control SCI is evident. The continuous use of a non-neurotoxic fibrin matrix could be a convenient strategy for in vitro NPC preparation, minimally invasive cell delivery, and better transplantation outcome.

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Section: Discussionmentioning

confidence: 71%

Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury

et al. 2021

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“…Takibini geciktirmesiyle, takrolimus dozu azaltılıp, diltiazem (orta derece CYP3A4 inhibitörü) kullanımı durdurulduğu halde ritonavir ilişkili takrolimus toksisitesi gelişti. Olguda takrolimus toksisitesinin bütün özellikleri mevcuttu; gastrointestinal yakınmalar, insülin bağımlı diyabetes mellitus (insülin salınımını azalması), akut böbrek hasarı (renal vazokonstriksiyon, hipoksi), hiperkalemi, hipertansiyon (endotelin artışı) ve nörotoksisite (direkt nöron hasarı, endotel disfonksiyonu) (11,15,16). Bu nedenle hem antiviral tedavi hem de kalsinorin inhibitörü alımının durdurulması gerekti.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

“…Bu denli ağır olgularda beyin MR görüntüleme yapılmalı ve destek tedavisi ile birlikte transplante böbrekten biyopsi örneği alınmalıdır. ABH nedeniyle benzer bir olgunun hemodiyaliz gereksinimi de ortaya çıkabilir ancak hemodiyaliz tedavisi plazmadaki kalsinorin inhibitörlerini uzaklaştıramamaktadır (9,11,16). Takip ettiğimiz olguda hızlı klinik düzelme olduğu için bu uygulamalara ihtiyaç duyulmadı.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

Böbrek Nakli Sonrası Hepatit C Virüs Enfeksiyonu Tedavisi ve İlaç Etkileşimleri; Olgu ve Literatürün Gözden Geçirilmesi

Erken¹,

Altunören²,

Tütüncü³

et al. 2018

Turk Neph Dial Transpl

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ÖZYeni direkt etkili antiviraller ile hepatit-C virüs (HCV) enfeksiyonunun etkin tedavisi mümkün olabilmektedir. Böbrek nakli sonrası ortaya çıkan veya nüks eden HCV enfeksiyonu tedavisi özenli bir yaklaşım gerektirir. Uygun tedavi seçimi yanında ilaç etkileşimleri de iyi bilinmelidir. Bu olgu sunumu ve literatür derlemesinde, HCV için tedavi başlandığı dönemde kalsinorin inhibitörü toksisitesi gelişen bir olguyu tanımlarken, böbrek nakli sonrası antiviral tedavide ilaç etkileşimlerine dikkat çekmeyi amaçladık. Kırk-sekiz yaşında böbrek nakilli erkek olgu genotip-1b nüks HCV enfeksiyonu için tedavi başlanması sonrasında ritonavir ile ilaç etkileşimine bağlı akut, şiddetli takrolimus toksisitesi nedeniyle takip edildi. Antiviral tedavi ve takrolimus kullanımı durduruldu. Klinik düzelme olduktan sonra hasta düşük doz siklosporin-A (CsA) eşliğinde antiviral tedavi alabildi ve sürdürülebilir viral yanıt elde edildi. Böbrek nakli alıcılarında uygun antiviral kombinasyonu seçerken HCV genotipi ve klinik özelliklerin yanı sıra immunosupressif ilaçlarla olası etkileşimlerin de dikkate alınması gerekeceği için, bu olgular hepatolog ve transplant nefroloğu tarafından yakın izlenmelidir. ANAHTAR SÖZCÜKLER: Böbrek nakli, Hepatit C virüs, İlaç etkileşimleri, Takrolimus, Ritonavir ABSTRACTNew direct acting antiviral agents are quite effective in treating hepatitis-C virus infection (HCV). Treating HCV that occurs or relapses after kidney transplantation necessitates a heedful approach for selecting the proper antiviral alternatives with respect to possible drug interactions. Here we want to lay emphasis on drug interactions in kidney transplant recipients along with a case that developed calcineurin inhibitor toxicity after initiation of anti-HCV treatment. A 48-year-old male was admitted after acute severe toxicity with tacrolimus due to a drug interaction with an antiviral regimen including ritonavir for relapsing genotype-1b HCV infection. Cessation of tacrolimus and antiviral therapy provided recovery. Sustained viral response was achieved with the same antiviral regimen with conversion to very low dose cyclosporine-A (CsA). Selection of a proper anti-HCV treatment combination for kidney transplant recipients requires consideration of the viral genotype, clinical features and possible drug interactions with immunosuppressives. These patients must therefore be followed by a hepatologist as well as a nephrologist.

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“…SCs transplanted into the lesion site of an injured spinal cord promote axon regeneration, and can also form myelin sheaths around axons [5,36,37]. Additional advantages associated with the use of SCs in spinal cord transplantation therapies include that they can be used as an autologous approach, precluding potential issues of an adverse immune response or the use of immunesuppressive treatments associated with cells from allogeneic sources [38][39][40]. After four decades of research, SCs therapy is currently in phase I clinical trials to evaluate the safety of autologous human SC transplantation after subacute and chronic SCI [41,42] (www.clinicaltrials.gov NCT02354625).…”

Section: Introductionmentioning

confidence: 99%

Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro

Chen

Maurel

et al. 2018

J. Neural Eng.

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Posttransplantation Encephalopaties

Cited by 3 publications

References 23 publications

Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury

Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury

Böbrek Nakli Sonrası Hepatit C Virüs Enfeksiyonu Tedavisi ve İlaç Etkileşimleri; Olgu ve Literatürün Gözden Geçirilmesi

Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro

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