Postsynthetic functionalization of covalent organic frameworks for dual channel fluorescence diagnosis of two indicators related to Parkinson's disease

Ratiometric Fluorescence Capillary Sensor-Integrated Molecular Imprinting for Simultaneous Detection of Two Biological Indicators of Parkinson’s Disease

“…The Si-CD@CdTe@CMIP had a broader determination range compared with other methods. The LOD of Si-CD@CdTe@CMIP was lower than that of trace analysis in previous studies. − ,− Importantly, the Si-CD@CdTe@CMIP method achieved the lower detection limit with a lower sample consumption of 18 μL, which proved that the Si-CD@CdTe@CMIP can be used for detection of trace samples.…”

“…Simultaneously, excessive levels of Al 3+ in the body can lead to serious diseases such as dementia, PD, and Alzheimer’s disease. Studies showed that the level of HVA decreases while the concentration of Al 3+ increases in PD patients. − Thus, simultaneous detection of HVA and Al 3+ is of great significance for the early diagnosis and monitoring of PD. Currently, the detection methods of HVA or Al 3+ included enzymatic immunological assays (EIA), liquid chromatography (LC), gas chromatography–mass spectrometry (GC–MS), and high-performance liquid chromatography (HPLC). − However, these methods have some shortcomings such as the lack of specificity, poor sensitivity, large reagent consumption, and individual determination …”

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…Based on the same principle of TAA-enhanced Eu( iii ) photoluminescence, in 2022, a TpBD-(COOH) 2 @Eu-TTA COF hydrogel was used for the simultaneous detection of vanilacetic acid and Al( iii ), both of which are associated with neurodegenerative diseases. 764 In aqueous solution, due to competitive energy absorption and dynamic quenching, vanilacetic acid led to fluorescence quenching at 614 nm, while Al( iii ) led to fluorescence quenching at 614 nm and enhancement at 412 nm. The detection limits for vanilacetic acid and Al( iii ) were 132 nM and 23.4 nM, respectively.…”

The postsynthetic renaissance of luminescent lanthanide ions on crystalline porous organic framework materials

“…118 Similarly, Wang et al adopted the solvent-free esterification reaction to turn TpBD-(OH) 2 COF with only hydroxyl groups into TpBD-(COOH) 2 COF with carboxyl groups and then anchored Eu 3+ ions onto the free carboxyl groups of TpBD-(COOH) 2 ; finally TTA was coordinated on Eu 3+ ions, which generated the Eu(TTA) @TpBD-(COOH) 2 material. 119 The Eu(TTA)@TpBD-(COOH) 2 material was encapsulated in agarose to fabricate an Eu(TTA) @TpBD-(COOH) 2 luminescent hydrogel (Fig. 12).…”

“…12 The preparation process from TpBD-(OH) 2 to the Eu(TTA) @TpBD-(COOH) 2 hydrogel by covalent PSM, two-step coordinated PSM, and doping into the hydrogel. 119 Therefore, hydrogen donor and acceptor sites are important for building HOF materials. Because of the tunable structural properties of organic molecules, researchers often design the functional groups on organic ligands, which determine the combination mode of organic linkers so that the designability of HOFs is achieved well.…”