Postsynaptic p47phox regulates long-term depression in the hippocampus

Yi, Jee Hyun; Kim, Dong Hyun; Piers, Thomas M.; Kim, Seung Chan; Whitcomb, Daniel J.; Regan, Philip; Cho, Kwangwook

doi:10.1038/s41421-018-0046-x

Cited by 10 publications

(10 citation statements)

References 51 publications

(75 reference statements)

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“…Post-synaptic NOX2 activity is also required for NMDARdependent LTD (Yi et al, 2018). LTD induced by low frequency stimulation on acute neuronal slices was dependent on postsynaptic expression of NOX2 as verified by shRNA knockdown of gp91 phox and p47 phox .…”

Section: Nox Involvement In Long-term Depression/potentiation and Synaptic Plasticitymentioning

confidence: 87%

“…Protein kinase C (PKC) is an important kinase family that phosphorylates p47 phox (Fontayne et al, 2002), which can be activated downstream of NMDAR activation and calcium influx. Early observations, just after the discovery of the expanded NOX family, demonstrated the necessity of both PKC and oxidant production for synaptic potentiation (Knapp and Klann, 2002), and since then, further evidence for the involvement of different PKC isoforms in NOX2 activation following NMDAR stimulation and synaptic plasticity in neurons has been provided (Brennan et al, 2009;Brennan-Minnella et al, 2013;Yi et al, 2018;Wang and Swanson, 2020).…”

Section: Nmdar Signaling and Nox2 Activationmentioning

confidence: 99%

“…Excitotoxic neuron death and superoxide formation could be prevented by the PI3K inhibitor wortmannin (and p47 phox knockout). The involvement of PKC-zeta has been further refined, as it has been demonstrated that specifically phosphorylation at position 316 of p47 phox is required for induction of LTD (Yi et al, 2018). Incidentally, generation of phosphoinositide species in the vesicular or plasma membrane by PI3K is also a direct recruitment factor for p40 phox and p47 phox , respectively, via their PX domains (Zhan et al, 2002;Ago et al, 2003;Ellson et al, 2006).…”

Section: Nmdar Signaling and Nox2 Activationmentioning

confidence: 99%

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Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

Villegas

Nørremølle

Freude

et al. 2021

Front. Aging Neurosci.

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Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by neuronal loss and tissue atrophy mainly in the striatum and cortex. In the early stages of the disease, impairment of neuronal function, synaptic dysfunction and white matter loss precedes neuronal death itself. Relative to other neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease and Amyotrophic Lateral Sclerosis, where the effects of either microglia or NADPH oxidases (NOXs) are recognized as important contributors to disease pathogenesis and progression, there is a pronounced lack of information in HD. This information void contrasts with evidence from human HD patients where blood monocytes and microglia are activated well before HD clinical symptoms (PET scans), and the clear signs of oxidative stress and inflammation in post mortem HD brain. Habitually, NOX activity and oxidative stress in the central nervous system (CNS) are equated with microglia, but research of the last two decades has carved out important roles for NOX enzyme function in neurons. Here, we will convey recent information about the function of NOX enzymes in neurons, and contemplate on putative roles of neuronal NOX in HD. We will focus on NOX-produced reactive oxygen species (ROS) as redox signaling molecules in/among neurons, and the specific roles of NOXs in important processes such as neurogenesis and lineage specification, neurite outgrowth and growth cone dynamics, and synaptic plasticity where NMDAR-dependent signaling, and long-term depression/potentiation are redox-regulated phenomena. HD animal models and induced pluripotent stem cell (iPSC) studies have made it clear that the very same physiological processes are also affected in HD, and we will speculate on possible roles for NOX in the pathogenesis and development of disease. Finally, we also take into account the limited information on microglia in HD and relate this to any contribution of NOX enzymes.

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Section: Nox Involvement In Long-term Depression/potentiation and Synaptic Plasticitymentioning

confidence: 87%

Section: Nmdar Signaling and Nox2 Activationmentioning

confidence: 99%

Section: Nmdar Signaling and Nox2 Activationmentioning

confidence: 99%

See 1 more Smart Citation

Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

Villegas

Nørremølle

Freude

et al. 2021

Front. Aging Neurosci.

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“…The organotypic hippocampal slice culture (Fig. 3) was prepared as previously described [31]. All steps were carried out under sterile conditions.…”

Section: Biological Samplesmentioning

confidence: 99%

Planar Airy beam light-sheet for two-photon microscopy

Hosny

Seyforth

Spickermann

et al. 2020

Biomed. Opt. Express

Self Cite

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We demonstrate the first planar Airy light-sheet microscope. Fluorescence light-sheet microscopy has become the method of choice to study large biological samples with cellular or sub-cellular resolution. The propagation-invariant Airy beam enables a tenfold increase in field-of-view with single-photon excitation; however, the characteristic asymmetry of the light-sheet limits its potential for multi-photon excitation. Here we show how a planar light-sheet can be formed from the curved propagation-invariant Airy beam. The resulting symmetric light sheet excites two-photon fluorescence uniformly across an extended field-of-view without the need for deconvolution. We demonstrate the method for rapid two-photon imaging of large volumes of neuronal tissue.

show abstract

“…The organotypic hippocampal slice culture (Fig. 3) was prepared as previously described 29 . All steps were carried out under sterile conditions.…”

Section: Biological Samplesmentioning

confidence: 99%

A planar Airy beam light-sheet for two-photon microscopy

Hosny,

Seyforth,

Spickermann

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

We demonstrate the first planar Airy light-sheet microscope. Fluorescence light-sheet microscopy has become the method of choice to study large biological samples with cellular or sub-cellular resolution. The propagation-invariant Airy beam enables a ten-fold increase in field-of-view with single-photon excitation; however, the characteristic asymmetry of the lightsheet limits its potential for multi-photon excitation.Here we show how a planar light-sheet can be formed from the curved propagation-invariant Airy beam. The resulting symmetric light sheet excites two-photon fluorescence uniformly across an extended field-of-view without the need for deconvolution. We demonstrate the method for rapid two-photon imaging of large volumes of neuronal tissue.

show abstract

Postsynaptic p47phox regulates long-term depression in the hippocampus

Cited by 10 publications

References 51 publications

Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

Planar Airy beam light-sheet for two-photon microscopy

A planar Airy beam light-sheet for two-photon microscopy

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