Postsurgical Pantoea calida meningitis: a case report

Fritz, Shirley; Cassir, Nadim; Noudel, R.; Rosa, S. De La; Roche, Pièrre-Hugues; Drancourt, Michel

doi:10.1186/1752-1947-8-195

Cited by 15 publications

(12 citation statements)

References 15 publications

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“…Similarly, Wang and Fraser have isolated P. agglomerans from the brain abscess that developed after infarction and hemicraniectomy [ 5 ]. A case report of Pantoea calida causing postsurgical meningitis in a 52-year-old female has been reported by Fritz et al [ 6 ]. Our isolation of P. agglomerans from a similar case indicates that Pantoea spp.…”

Section: Discussionmentioning

confidence: 99%

Pantoea agglomerans Infections in Children: Report of Two Cases

Siwakoti

Sah

Rajbhandari

et al. 2018

Case Reports in Pediatrics

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Introduction Pantoea agglomerans, primarily an environmental and agricultural organism has been reported as both commensal and pathogen of humans. We present two case reports of P. agglomerans infections in children that involved the meninges and bloodstream. Case Presentations A 6-month-old female baby, diagnosed as congenital hydrocephalus secondary to aqueduct stenosis with ventriculoperitoneal shunt in situ, operated 14 days back was brought to the pediatric emergency with a two-day history of high fever associated with vomiting, irritability, excessive crying, and decreased feeding. Postoperative meningitis was confirmed as cerebrospinal fluid culture revealed P. agglomerans. She responded well with a 14-day intravenous (IV) course of ceftriaxone. Also, we report a case of a 3-year-old male child referred to our center with a provisional diagnosis of UTI with chickenpox for further evaluation. During his 24-hour stay at the local hospital, he had received oral antibiotics and urinary catherization. Urine culture of catheter clamp urine was sterile. P. agglomerans was grown in blood culture. He was treated successfully with IV ceftriaxone and amikacin. Conclusion P. agglomerans can cause postsurgical meningitis and bloodstream infection in children. The clinical course of infection was mild and timely administration of proper antibiotic resulted in a favorable outcome.

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Section: Discussionmentioning

confidence: 99%

Pantoea agglomerans Infections in Children: Report of Two Cases

Siwakoti

Sah

Rajbhandari

et al. 2018

Case Reports in Pediatrics

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“…recovered in our survey rarely cause humans harm. 30,31 However, they were able to transfer cephalosporin resistance to bacteria that do infect patients. Horizontal gene transfer will happen most frequently in areas of high bacterial density.…”

Section: Discussionmentioning

confidence: 99%

ESBL-producing Gram-negative organisms in the healthcare environment as a source of genetic material for resistance in human infections

Muzslay

Moore

Alhussaini

et al. 2017

Journal of Hospital Infection

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SUMMARY BackgroundThe increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriacae in the healthcare setting and in the community despite established infection control guidelines indicates that these microorganisms may possess survival strategies that allow them to persist in the environment. Aims To determine the extent and variation in endemic ESBL-carrying species in different ward environments. To investigate the potential for cephalosporin resistance to be transferred from environmental isolates to human pathogens. Methods Conventional microbiological methods were used to sample 1436 environmental surfaces for ESBL-producing bacteria. Transconjugation assays (broth mating experiments) were performed using environmental ESBL-producing isolates as donors and streptomycin-resistant Escherichia coli (NCTC 50237) as the recipient. FindingsThe prevalence of ESBL-producing bacteria on surfaces in a non-outbreak setting was low (45/1436; 3.1%). The sites most likely to be contaminated were the drains of handwash basins (28/105; 26.7%) and floors (14/160; 8.8%). Fifty-nine ESBL-carrying organisms were isolated. Of these, Klebsiella spp (33.9%), Enterobacter spp (20.3%), Pantoea spp (15.3%) and Citrobacter spp (13.6%), were the most common isolates. ESBL determinants were successfully transferred from three representative environmental isolates (Pantoea calida, Klebsiella oxytoca, Raoultella ornithinolytica) to the human pathogen E. coli. Conclusion ESBL-producing Gram-negative isolates were recovered from the hospital environment in the absence of any ESBL infection on the wards. The drains of hand wash basins should be considered potential long-term reservoirs of multi-drug resistant bacteria and drug resistance genes. These genes can reside in various genera of hardy environmental organisms and be a potential source of ESBL for more common human pathogens.

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“…For example, Pantoea ananatis causes maize white spot disease (Bomfeti et al , 2008) and Pantoea agglomerans causes nosocomial infections in immunocompromised patients (Cruz et al , 2007). Fritz et al (2014) recently demonstrated that some strains of Pantoea calida were the causal agent of post-surgical meningitis in humans. Pantoea species serve as plant epiphytes or endophytes; they are also used as biocontrol agents (De Maayer et al , 2012a, b; Swart, 2009).…”

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confidence: 99%

Pantoea intestinalis sp. nov., isolated from the human gut

Prakash

Nimonkar

Vaishampayan

et al. 2015

International Journal of Systematic and Evolutionary Microbiology

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A novel bacterial strain, 29Y89B T , was isolated from a faecal sample of a healthy human subject. Cells were Gram-stain-negative, motile, non-spore-forming and rod-shaped. Strain 29Y89B T formed cream-coloured colonies 2 mm in diameter on trypticase soy agar and showed optimum growth at 35 8C. Strain 29Y89B T showed highest 16S rRNA gene sequence similarity to Pantoea gaviniae A18/07 T (98.4 %) followed by Pantoea calida 1400/07 T (97.2 %). Multi-locus sequence analysis using atpD (ATP synthase b subunit), gyrB (DNA gyrase), infB (initiation translation factor 2) and rpoB (RNA polymerase b subunit) genes also supported the result of 16S rRNA gene sequence based phylogeny. Strain 29Y89B T showed 62 and 40.7 % DNA-DNA relatedness with P. calida DSM 22759 T and P. gaviniae DSM 22758 T . Strain 29Y89B T contained C 17 : 0 cyclo, C 19 : 0 cyclo v8c, C 16 : 0 , C 14 : 0 and C 12 : 0 as predominant fatty acids. In addition, strain 29Y89B T showed physiological and phenotypic differences from its closest relatives P. gaviniae DSM 22758 T and P. calida DSM 22759 T . The polar lipid profile mainly comprised phospholipids. The DNA G+C content was 59.1 mol%. Thus, based on the findings of the current study, strain 29Y89B T showed clear delineations from its closest relatives P. gaviniae DSM 22758 T and P. calida DSM 22759 T , and is thus considered to represent a novel species of the genus Pantoea, for which the name Pantoea intestinalis sp. nov. is proposed. The type strain is 29Y89B T (5DSM 28113 T 5MCC 2554 T ).The human gut is a complex reservoir of trillions of microbes (De Filippo et al., 2010;Gill et al., 2006;Kallus & Brandt, 2012;Kau et al., 2011). These microbial cells outnumber the human body cells by about 100 times (Fujimura et al., 2010). Gut bacteria perform important functions and protect the host against pathogen invasion, improve the host's metabolic activities, enhance the host's immunity (De Filippo et al., 2010), and play an important role in the host's pathogenesis and obesity (Zhang et al., 2009). They help the host in extracting energy from fermentation of undigested carbohydrates and subsequent absorption of short chain fatty acids (Cummings & Macfarlane, 1997). Most reports on the human microbiome have been mainly based on cultureindependent molecular studies. Culture-independent approaches have provided deeper insight into the unexplored diversity of micro-organisms, which could not be attained through culture-dependent studies (Hugenholtz et al., 1998). However, culture-independent methodologies fail to clarify the functionality of micro-organisms (Prakash et al., 2013b). Thus, it is essential to cultivate the bacteria for a better understanding of their physiology and functions regarding host health and ecology.The family Enterobacteriaceae contains members of the genera Escherichia, Klebsiella, Citrobacter, Yersinia, Salmonella, Shigella, Enterobacter, Pantoea and many others. The genus Pantoea was first reported by Gavini et al. (1989). Members of the genus Pantoea are Gram-stainnegative, co...

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Postsurgical Pantoea calida meningitis: a case report

Cited by 15 publications

References 15 publications

Pantoea agglomerans Infections in Children: Report of Two Cases

Pantoea agglomerans Infections in Children: Report of Two Cases

ESBL-producing Gram-negative organisms in the healthcare environment as a source of genetic material for resistance in human infections

Pantoea intestinalis sp. nov., isolated from the human gut

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