Poststroke Depression and Risk of Recurrent Stroke at 1 Year in a Chinese Cohort Study

Abstract

BackgroundStudies show that poststroke depression (PSD) increases mortality risk at 1 year. However, whether PSD increases the risk of recurrent stroke at 1 year remains unclear. This study was to investigate whether PSD at 2 weeks following a stroke could increase risk of recurrent stroke at 1 year.Methods and ResultsThis was a multi-centered prospective cohort study. A total of 2306 patients with acute stroke were enrolled in our study. PSD was diagnosed according to the criteria set by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). The outcomes of recurrent stroke were followed up via face-to-face or phone interview. A total of 1713 patients had complete follow-up data, with 481 (28.1%) cases of PSD and 158 (9.2%) cases of cumulative recurrent stroke at 1 year. Multivariate logistic regression analysis showed a 49% increase of OR of recurrent stroke at 1 year in patients with PSD, compared to patients without PSD following a stroke (OR = 1.49, 95%CI: 1.03–2.15). There was no significant correlation between anti-depressant drugs and the risk of recurrent stroke at 1 year following a stroke (OR = 1.96, 95%: CI 0.95–4.04).ConclusionsBased on the DSM-IV diagnostic criteria, nearly 3 out of 10 hospitalized stroke patients in China were diagnosed with PSD at 2 weeks following a stroke. PSD is associated with a higher risk of recurrent stroke at 1 year. Our study did not find benefit of anti-depressant drugs in reducing such risk.

Depression in Older Residents With Stroke Living in Long-Term Care Facilities

“…These results were consistent with previous studies of depression in older patients with stroke (Cheng et al, 2005;Li et al, 2003). However, previous studies of communitydwelling patients with stroke suggested that being a woman (Liao et al, 2004), being older (Farner et al, 2010), and having a higher risk of stroke recurrence (Yuan et al, 2012) were significantly associated with depression symptoms. More studies are needed to confirm our research findings regarding the relationships between demographic data and depression in older residents of LTCFs with stroke.…”

“…Poststroke depression has been associated with brain damage and increased disability, cognitive impairment, and mortality (Robinson, 2003;Whyte & Mulsant, 2002). Previous studies have shown that gender (Liao et al, 2004), age (Farner et al, 2010;Hornsten, Molander, & Gustafson, 2012), and risk of recurrent stroke (Yuan et al, 2012) are factors associated with depressive symptoms in poststroke patients.…”

Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression

“…PSD significantly influences the patients' cognition, recovery and daily life. It is reported that the morbidity of PSD within two weeks is 28.1% [3,4], within a year is 61%, and within two years is 79% [5,6]. However, benefit of present used antidepressant drug was not satisfactory [7,8].…”

Proton Magnetic Resonance Spectroscopy Study on the Metabolism Changes of Cerebellum in Patients with Post-Stroke Depression

“…PSD significantly affects the cognition, recovery and daily life of the stroke patients. It has been reported that the incidence of PSD was 28.1% in 2 weeks after stroke attack, 61% within 1 year, even higher (79%) in 2nd year following the stroke [2, 3]. Nevertheless, the clinical efficacy of the current anti-depression agents is relatively limited [4].…”