Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression

Zhang, Ling; Sui, Rubo; Zhang, Lei; Zhang, Zhuang

doi:10.1159/000452557

Cited by 9 publications

(4 citation statements)

References 29 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Tables 1 and 3 , significant differences were found in NIHSS, HAMD, HAMA, and MMSE scores between the two groups, indicating that neurological deficits were more serious in the PSD group. Other studies also showed the same results [ 16 , 17 ]. Further, a significant difference was found in frontal and parietal lesions between the two groups.…”

Section: Discussionsupporting

confidence: 77%

Predictors of early-onset post-ischemic stroke depression: a cross-sectional study

Meng

et al. 2017

BMC Neurol

View full text Add to dashboard Cite

BackgroundPost-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD.MethodsPatients with an acute ischemic stroke, who met the inclusion criteria at Shanghai Tenth People’s Hospital from April 2016 to September 2016, were recruited for this study. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and the mental state was assessed using Mini-Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) at 1 week of admission. The patients were divided into PSD and non-PSD groups. The demographic and clinical characteristics, as well as the biochemical factors, were compared between the two groups. A logistic regression analysis was performed to identify the risk factors for depression following stroke.ResultsA total of 83 patients with acute ischemic stroke were recruited. Of these, 36 (43.4%) developed depression. The multivariate logistic regression analysis indicated that high NIHSS [odds ratio (OR): 1.84, 95% confidence interval (CI): 1.09–3.12, P = 0.023] and high HAMD scores (OR: 2.38, 95% CI: 1.61–3.50, P < 0.001) were independent risk predictors for PSD and so were lower dopamine level (OR: 0.64, 95% CI: 0.45–0.91, P = 0.014), lower 5-hydroxytryptamine level (OR: 0.99, 95% CI: 0.98–1.00, P = 0.046), higher tumor necrosis factor-α level (OR: 1.05, 95% CI: 1.00–1.09, P = 0.044), and lower nerve growth factor level (OR: 0.06, 95% CI: 0.01–0.67, P = 0.022).ConclusionsThe identification of higher NIHSS scores, higher HAMD scores, lower dopamine level, lower 5-hydroxytryptamine level, higher tumor necrosis factor-α level, and lower nerve growth factor level might be useful for clinicians in recognizing and treating depression in patients after a stroke.

show abstract

Section: Discussionsupporting

confidence: 77%

Predictors of early-onset post-ischemic stroke depression: a cross-sectional study

Meng

et al. 2017

BMC Neurol

View full text Add to dashboard Cite

show abstract

“…Dietary regimens serve as a major risk factor for disability and mortality caused by chronic diseases and nutritional interventions with dietary restriction has been reported to improve metabolic homeostasis, − which is highly associated with longevity and health . In various models, protein restriction without malnutrition has been consistently identified to prevent disease development and promote healthspan via metabolic reprogramming. , In clinic, low-protein diets are widely introduced to patients with kidney diseases, such as early and advanced stage chronic kidney disease .…”

Section: Introductionmentioning

confidence: 99%

Metabolic and Proteomic Responses to Long-Term Protein Restriction in a Pig Model

Yin

Han

et al. 2018

J. Agric. Food Chem.

View full text Add to dashboard Cite

Protein restriction is associated with extended lifespan and reduced incidence and progression of multiple age-related diseases. The underlying mechanism of metabolic and proteomic responses to the long-term dietary protein restriction, however, has not been fully uncovered. The present study aimed to identify the metabolic and proteomic profiles in a low-protein diet-fed pig model. Intestinal and liver metabolomics showed that amino acid metabolism was highly associated with dietary protein restriction. Interestingly, blood was characterized by markedly higher abundances of Ser, Gly, Glu, Thr, Ala, Lys, and Met levels, and lower abundances of His, Val, and Ile levels regardless of the age of pigs from piglets to adult pigs. Amino acid transporters might contribute to the changed amino acid pools and serve as a feedback regulatory mechanism in response to protein restriction. iTRAQ-based quantitative proteomics approach identified more than 10 differently expressed proteins in protein restricted pigs and KEGG pathway analysis showed that significant enrichment of proteins involved in metabolic pathways, PI3K-Akt signaling pathway, lysosome, spliceosome, oxidative phosphorylation, phagosome, and DNA replication. Western blot analysis further confirmed that protein restriction markedly inactivated Akt and mTOR signals in pigs. This study indicates that dietary protein restriction leads to a shift in the host metabolism in a pig model, especially for amino acid metabolism. Along with proteomics, our findings unveil potential mechanisms for integrating how protein restriction modulates host metabolism.

show abstract

“…The cerebellum is an important cerebral region, which responds to the controls of movement and balance perception. Previous neuroimaging studies have reported that cerebrovascular disease is associated with cerebellar dysfunction (Zhang et al, 2016;Koch et al, 2019). Dong et al (2007) demonstrated that stroke patients showed fMRI activation in the perilesional primary motor cortex and cerebellum with training-related motor gains after stroke.…”

Section: Discussionmentioning

confidence: 99%

Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study

Xiao

Gan²,

Liu³

et al. 2022

Front. Hum. Neurosci.

View full text Add to dashboard Cite

ObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrated that RVO was accompanied by cerebral changes, and was related to stroke. The purpose of the study is to investigate synchronous neural activity changes in patients with RVO.MethodsA total of 50 patients with RVO and 48 healthy subjects with matched sex, age, and education were enrolled in the study. The ReHo method was applied to investigate synchronous neural activity changes in patients with RVO.ResultsCompared with HC, patients with RVO showed increased ReHo values in the bilateral cerebellum_4_5. On the contrary, patients with RVO had decreased ReHo values in the bilateral middle occipital gyrus, right cerebelum_crus1, and right inferior temporal gyrus.ConclusionOur study demonstrated that patients with RVO were associated with abnormal synchronous neural activities in the cerebellum, middle occipital gyrus, and inferior temporal gyrus. These findings shed new insight into neural mechanisms of vision loss in patients with RVO.

show abstract

Morphological and Metabolic Alteration of Cerebellum in Patients with Post-Stroke Depression

Cited by 9 publications

References 29 publications

Predictors of early-onset post-ischemic stroke depression: a cross-sectional study

Predictors of early-onset post-ischemic stroke depression: a cross-sectional study

Metabolic and Proteomic Responses to Long-Term Protein Restriction in a Pig Model

Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study

Contact Info

Product

Resources

About