Postrenal transplant Plasmodium vivax malaria: neglected and not benign

Kute, Vivek B.; Vanikar, Aruna V; Shah, Pankaj; Shrimali, Jigar D; Gumber, Manoj R.; Patel, Himanshu V.; Modi, Pranjal; Trivedi, Hargovind L

doi:10.1007/s00436-012-3225-y

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…In endemic countries, Plasmodium sp. could be transferred with solid organ or bone marrow transplants [ 1 , 14 ]. P. falciparum can survive at the standard graft preservation temperature (40 °C) for up to 24 h [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Parasitic Infections Associated with Unfavourable Outcomes in Transplant Recipients

Wołyniec

Sulima²,

Renke

et al. 2018

Medicina

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Introduction. The immunosuppression used after transplantation (Tx) is associated with an increased risk of opportunistic infections. In Europe, parasitic infections after Tx are much less common than viral, bacterial and fungal ones. However, diseases caused by parasites are very common in tropical countries. In the last years the number of travellers with immunosuppression visiting tropical countries has increased. Methods. We performed a literature review to evaluate a risk of parasitic infections after Tx in Europe. Results. There is a real risk of parasitic infection in patients after Tx travelling to tropical countries. Malaria, leishmaniasis, strongyloidiasis and schistosomiasis are the most dangerous and relatively common. Although the incidence of these tropical infections after Tx has not increased, the course of disease could be fatal. There are also some cosmopolitan parasitic infections dangerous for patients after Tx. The greatest threat in Europe is toxoplasmosis, especially in heart and bone marrow recipients. The most severe manifestations of toxoplasmosis are myocarditis, encephalitis and disseminated disease. Diarrhoea is one of the most common symptoms of parasitic infection. In Europe the most prevalent pathogens causing diarrhoea are Giardia duodenalis and Cryptosporidium. Conclusions. Solid organ and bone marrow transplantations, blood transfusions and immunosuppressive treatment are associated with a small but real risk of parasitic infections in European citizens. In patients with severe parasitic infection, i.e., those with lung or brain involvement or a disseminated disease, the progression is very rapid and the prognosis is bad. Establishing a diagnosis before the patient’s death is challenging.

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Section: Resultsmentioning

confidence: 99%

Parasitic Infections Associated with Unfavourable Outcomes in Transplant Recipients

Wołyniec

Sulima²,

Renke

et al. 2018

Medicina

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“…Primary infection or reinfection is a distinct risk in exposed transplant recipients. In published and available literature, post-transplant malaria reported cases involve kidney (16 cases, 59.3%), liver (5 cases, 18.5%), and heart (2 cases, 7.4%) [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. Among these patients, 13 had a primary infection due to well clarified transmission through allograft (n 11, 40.7%) or blood/blood products (n 1, 3.7%), and 1 patient (3.7%) had a documented de novo infection.…”

Section: Discussionmentioning

confidence: 99%

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

2018

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The aim of this study was to evaluate the occurrence of parasitic infections in solid organ transplant (SOT) recipients. We conducted a systematic review of literature records on post-transplant parasitic infections, published from 1996 to 2016 and available on PubMed database, focusing only on parasitic infections acquired after SOT. The methods and findings of the present review have been presented based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. From data published in the literature, the real burden of parasitic infections among SOT recipients cannot really be estimated. Nevertheless, publications on the matter are on the increase, probably due to more than one reason: (i) the increasing number of patients transplanted and then treated with immunosuppressive agents; (ii) the “population shift” resulting from immigration and travels to endemic areas, and (iii) the increased attention directed to diagnosis/notification/publication of cases. Considering parasitic infections as emerging and potentially serious in their evolution, additional strategies for the prevention, careful screening and follow-up, with a high level of awareness, identification, and pre-emptive therapy are needed in transplant recipients.

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“…Plasmodium vivax has been recently considered by multiple authors as a neglected parasite (Carlton et al 2011;de Lacerda et al 2007;Gething et al 2012;Kute et al 2012aKute et al , 2013Mendis et al 2001;Acharya et al 2011;Mueller et al 2009). Even more, in the past decade, new considerations have been made on its associated severity and mortality (Gulati 2012;Picot and Bienvenu 2009;Price et al 2007;Singh et al 2011;Vinetz 2006).…”

Section: Discussionmentioning

confidence: 99%