2003
DOI: 10.1042/bst0311090
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Postprandial lipaemia in familial combined hyperlipidaemia

Abstract: FCHL (familial combined hyperlipidaemia) is the most frequent inherited disorder of lipid metabolism leading to premature atherosclerosis. The usual phenotype in FCHL is elevated fasting plasma triacylglycerols, low HDL (high-density lipoprotein)-cholesterol concentrations and elevated plasma apolipoprotein B concentrations. The metabolic basis for this phenotype is hepatic overproduction of VLDL (very-low-density lipoprotein), which is only partly linked to the insulin resistance associated with FCHL. At this… Show more

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Cited by 11 publications
(6 citation statements)
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“…Along with TRL, diminished lipoprotein clearance associated to IR-mediated decreased LPL activity, leads to sdLDL and intermediate-density lipoprotein particle accumulation, both of which are highly atherogenic and easily oxidized, contributing to its entry into subendothelial pathways 3,43 . Decreased adiponectin levels in the setting of IR have been linked to higher levels of apoB and VLDL particles, further contributing to atherogenesis 44 , which might be feasible in the setting of FCHL.…”
Section: Pathophysiology Of Fchlmentioning
confidence: 99%
“…Along with TRL, diminished lipoprotein clearance associated to IR-mediated decreased LPL activity, leads to sdLDL and intermediate-density lipoprotein particle accumulation, both of which are highly atherogenic and easily oxidized, contributing to its entry into subendothelial pathways 3,43 . Decreased adiponectin levels in the setting of IR have been linked to higher levels of apoB and VLDL particles, further contributing to atherogenesis 44 , which might be feasible in the setting of FCHL.…”
Section: Pathophysiology Of Fchlmentioning
confidence: 99%
“…Plant stanols decrease plasma cholesterol concentrations by reducing the intestinal absorption of cholesterol, thereby increasing the hepatic expression of LDL receptors and reducing the production of endogenous LDL cholesterol (5). This effect of stanols may reduce the risk of atherosclerosis (6). Combinations of plant stanols with antilipidemic drugs have been found to be more effective than individual usage, and an additional 17 % drop in serum cholesterol level was achieved using such a combination (7).…”
Section: Introductionmentioning
confidence: 99%
“…Here, we will consider only susceptibility genes for complex lipid-related disorders that have been identified by whole genome linkage and positional cloning. A striking example is the identification of a gene contributing to FCHL, which is characterized by increased serum cholesterol and triglyceride levels and is the most common familial lipid disorder predisposing to premature heart disease (89). Using whole genome scans in a Finnish population, a QTL for FCHL was identified on chromosome 1q21-23 (90).…”
Section: Positional Cloning Of Genes Underlying Complex Traitsmentioning
confidence: 99%