Postprandial hypertriglyceridemia and oxidative stress in patients of type 2 diabetes mellitus with macrovascular complications

Meal Induced Oxidative Stress Levels in Controlled and Poorly Controlled Diabetes

“…Studies have demonstrated a positive correlation between PP TBARS and TG [16][17][18] and that with PG [19]. This marker of oxidative stress has also been found to have a positive correlation with endothelial dysfunction [18].…”

Antidiabetic potential of α-amylase inhibitor from the seeds ofMacrotyloma uniflorumin streptozotocin-nicotinamide-induced diabetic mice

“…Hyperglycemia produces a marked increase in serum triglycerides and total cholesterol (Saxena et al, 2005). Lipid abnormalities along with premature atherosclerosis are the major cause of cardiovascular diseases in diabetic patients.…”

Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

“…A lifestyle approach of modifying dietary intake might be considered a "first line" defense to decrease both fasting and postprandial oxidative stress. It should be noted that unlike exercise, for which the oxidative stress response is typically short lived, the oxidative stress response following a high calorie, high fat meal may persist for several hours (e.g., 4-6) following feeding (Bloomer, Cole et al, 2009;Melton et al, 2009;Saxena et al, 2005), and the response is exacerbated in those who are obese ).…”

“…The severity of the oxidative load imposed appears dependent on the magnitude and rate of glycemia and lipemia experienced post-feeding (O'Keefe & Bell, 2007). Indeed, moderate to strong correlations exist for both glucose (Monnier et al, 2006) and triglycerides (Bae et al, 2001;Bloomer, Ferebee et al, 2009;Saxena et al, 2005) and oxidative stress biomarkers post-feeding. Studies have included a variety of meals to induce an oxidative stress, ranging from isolated protein, carbohydrate, and fat, to mixed meals involving some combination of macronutrients.…”

“…As highlighted earlier, reducing postprandial triglyceride levels is of particular importance, as this rise in circulating lipids post-feeding may be associated to increased risk for cardiovascular disease, possibly linked to the formation of RONS (Bae et al, 2001). It is well documented that a positive correlation exists between postprandial triglyceride levels and oxidative stress biomarkers (Bae et al, 2001;Bloomer, Ferebee et al, 2009;Bloomer & FisherWellman, 2010;Saxena et al, 2005). Therefore, if exercise is successful at reducing postprandial triglycerides, it may also be associated with a decrease in oxidative stress.…”