Postprandial hypertriglyceridaemia in type 2 diabetic subjects

Raj, Sumesh; Rajasekharan, C.; Jayakumar, B

doi:10.4103/0973-3930.33182

Cited by 8 publications

(19 citation statements)

References 4 publications

(3 reference statements)

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“…The increased risk of atherosclerosis among them, may therefore, be related to the higher postprandial lipaemia in them. The earlier studies which were done in our institution, clearly demonstrate the presence of postprandial hypertriglyceridaemia among the diabetic subjects, irrespective of the fasting triglyceride levels [15].…”

Section: Discussionsupporting

confidence: 50%

A Comparative Study on the Fasting and the Postprandial Dyslipidaemia in Type 2 Diabetes Mellitus

L¹

2013

JCDR

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Background and Objectives: Type 2 Diabetes Mellitus (Type 2 DM), which is characterized by a relative insulin deficiency or insulin resistance is associated with a cluster of metabolic abnormalities, which includes glucose intolerance, hypertension, a unique dyslipidaemia, a procoagulant state, and an increase in macrovascular diseases. The present study was conducted to assess the significance of postprandial dyslipidaemia with respect to fasting dyslipidaemia, in the pathogenesis of atherosclerotic changes and possible cardiovascular diseases (CVD) and complications. Methods and Statistical Analysis:Fifty diagnosed cases of type 2 DM which were in the age group of 35-65 years, which had a duration of diabetes of more than five years, were included in the study and 50 age and sex matched healthy subjects were taken as the controls. In both the study groups, we measured the serum levels of fasting as well as the postprandial lipid profile, which was comprised of the total Cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and the waist-hip ratio (WHI) as the cardiovascular risk factors. The statistical analysis was done by using the Students unpaired't'-test. Results:The results of this study showed significantly increased levels of serum total cholesterol, TGs, LDL-C and VLDL-C in the postprandial state as compared to those in the fasting state (p<0.001) and as compared to those in the fasting and the postprandial states of the controls (p<0.001). The serum HDL-C level was significantly lower in the postprandial state as compared to that in the fasting state (p<0.001). Also, the postprandial and the fasting HDL-C levels were significantly lower as compared to the levels in their respective control groups (p<0.001).

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Section: Discussionsupporting

confidence: 50%

A Comparative Study on the Fasting and the Postprandial Dyslipidaemia in Type 2 Diabetes Mellitus

L¹

2013

JCDR

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“…Similar observations were made in the studies done by Rajesh et al, however, in the study done by Raj S et al, it was found that diabetics had significantly higher levels of TC compared to the controls (p <0.05). 7 In this study, the cases had a mean TC level of 169.70±39.917mg/dL in the fasting state and 180.74±38.76mg/dL in the postprandial state. The controls had a mean TC level of 168.02±34.65mg/dL in the fasting state and 165.06±39.27mg/dL in the postprandial state.…”

Section: Discussionmentioning

confidence: 54%

“…Present study was consistent with the study done by Sumesh Raj et al ( Table 2). 7 In this study, 60% of the cases with dyslipidemia had poor glycemic control (HbA1C >7%) whereas 27% of the cases with dyslipidemia had good glycemic control (HbA1C <7%). This association has a p value of 0.738, which was statistically not significant.…”

Section: Discussionmentioning

confidence: 56%

“…6 The results are consistent with a similar study done by Raj S et al, in the year 2005 at Trivandrum, India, wherein the mean age of the cases was 56.6±11.9 years and that of the controls was 53.5±12.7 years (Figure 1). 7 In this study, 50% of the study group were males and 50% of the study group were females. The males and females were almost equally distributed with a male:female ratio of 1:1 ( Table 1).…”

Section: Discussionmentioning

confidence: 59%

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Lipid profile in type 2 diabetes mellitus: a case-controlled study

Rajendran¹,

Mallampati²,

Jha³

et al. 2019

Int J Adv Med

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Background: Atherosclerosis is caused by the combination of type 2 diabetes mellitus and dyslipidemia. Combination of DM and dyslipidemia is associated with increased mortality and morbidity. Hence, it is of utmost importance to know the nature of dyslipidemia in DM for its effective management. The major lipid abnormalities seen in DM are elevated triglyceride levels and lowered HDL-C levels.Methods: A case-controlled study was initiated in Vinayaka Missions Medical college and hospital for a period of 2 year. Pre-prandial and post-prandial lipid profile was assessed in 50 cases of type 2 DM and was compared with age and sex matched healthy controls satisfying the inclusion and exclusion criteria.Results: At the end of the study, the mean age±SD was 48.5±5.68 years. The mean HbA1c±SD of the study population was found to be 7.48±1.517. Looking at the lipid profile all cases in fasting state had elevated VLDL-C levels (mean 50.39±60.27), elevated TC (mean 169.70±39.917), elevated TGL (mean 146.04±60.140) and low LDL-C (mean 92.3±27.699) when compared to control group. In the postprandial state, there was a significant raise in TGL level (mean 188±68.59), raised TC (mean 180.74±38.46), decreased HDL-C (mean 38.761±9.028) compared to the fasting state.Conclusions: Lipid profile of type 2 DM in pre-prandial 12 hour fasting state showed elevated TC, VLDL-C levels and low LDL-C and HDL-C levels. Where as in post prandial state TGL levels were markedly elevated with elevated TC and low HDL-C levels.

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“…11,12 However, direct comparison study between groups according to their body weight with or without diabetes based on the normal daily diet are scarce. 13,14 Hence, the major aim of our study was to investigate the effects of body weight and gender difference on postprandial lipid and glucose responses in adult patients with type 2 diabetes.…”

mentioning

confidence: 99%

Effect of Gender and Body Weight on Postprandial Glucose and Lipid Metabolism in Adults with Type 2 Diabetes

et al. 2014

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Introduction: The magnitude of the healthcare problem of type-2-diabetes increases according to its association with several risk factors for cardiovascular diseases such as obesity and dyslipidemia. Methods: This study took place in the north-western region of Algeria. We aimed to assess the effect of body weight and gender on postprandial lipid and glucose in type-2-diabetes patients. 93 diabetic patients (age 55.65±13.81 years) were studied. Anthropometric parameters and body mass index (BMI) were measured. Fasting and postprandial (PP) glucose and lipid (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, apo A-I and apo B) profiles were evaluated. Results: There were a positive correlation between postprandial glucose and BMI in women (r2 = 0.041). Negative correlation with BMI was noticed for PP TG in both males (r2 = 0.011) and females (r2 = 0.021). A significant difference (p= 0.019) was observed for PP HDL-c in women (0.39 ± 0.10 g/L vs. men 0.33 ± 0.12 g/L) and also for PP apo A-I (women: 1.33 ± 0.27 g/L vs. men: 1.09 ± 0.34 g/L; p= 0.0003). According to gender and weight groups, our results indicated that female gender and overweight are associated with elevated PP HDL-c and PP apo A-I levels. However, obesity in women is related to high concentration of PP TG. Conclusions: The present study suggests that gender difference and weight classes are important factors that contribute to determining the postprandial responses, both for glucose and lipids, in type 2 diabetic patients. Keywords: gender difference; postprandial dyslipidemia; type 2 diabetes; weight groups.

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Postprandial hypertriglyceridaemia in type 2 diabetic subjects

Cited by 8 publications

References 4 publications

A Comparative Study on the Fasting and the Postprandial Dyslipidaemia in Type 2 Diabetes Mellitus

A Comparative Study on the Fasting and the Postprandial Dyslipidaemia in Type 2 Diabetes Mellitus

Lipid profile in type 2 diabetes mellitus: a case-controlled study

Effect of Gender and Body Weight on Postprandial Glucose and Lipid Metabolism in Adults with Type 2 Diabetes

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