Postprandial Elevation of Remnant Lipoprotein Leads to Endothelial Dysfunction

Funada, Junichi; Sekiya, Motohiro; Hamada, Mareomi; Hiwada, Kunio

doi:10.1253/circj.66.127

Cited by 38 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, endothelial dysfunction may influence postprandial changes in arterial stiffness. However, our earlier study did not show significant changes in flow-mediated dilatation after 24 g of fat loading, 34 suggesting that the amount of fat loaded in this study has little influence on endothelial function. In addition, Raitakari et al…”

Section: Discussioncontrasting

confidence: 73%

Influence of meal intake on pulse wave indices in type 2 diabetes

et al. 2010

Self Cite

View full text Add to dashboard Cite

Augmentation index (AI), brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) are available for the assessment of arterial stiffness in clinical practices. However, influences of meal intake on these indices are still poorly understood. The aim of this study is to elucidate the effects of daily meal intake on pulse wave indices in patients with type 2 diabetes. We studied 17 patients with type 2 diabetes. AI was measured at fasting, 60 and 120 min after a commercial mixed meal (500 kcal) intake. The baPWV and CAVI were measured at fasting and 80-100 min after meal intake. All pulse indices decreased significantly after meal intake (AI, 89.3 ± 9.7% to 77.9 ± 9.4%, 82.0 ± 8.4%, Po0.001; baPWV, 1652 ± 286-1586±240 cm s -1 , P¼0.002; CAVI, 9.52±0.92-9.20±0.89, P¼0.037). D 120 (value 120 min after meal intakeÀfasting value) AI correlated significantly with age, body weight, D 120 systolic blood pressure (SBP), D 120 diastolic blood pressure, D 120 pulse pressure, D 120 heart rate and fasting AI. D (postprandial valueÀfasting value) baPWV correlated significantly with fasting baPWV, D SBP, D pulse pressure and HbA1c. In contrast, D CAVI did not correlate with any clinical variables. In conclusion, postprandial decreases in AI, baPWV and CAVI can lead to underestimate arterial stiffness in patients with type 2 diabetes. Postprandial changes in AI and baPWV, but not CAVI, are associated with changes in hemodynamic variables after daily meal intake.

show abstract

Section: Discussioncontrasting

confidence: 73%

Influence of meal intake on pulse wave indices in type 2 diabetes

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…32 Funada et al have reported that postprandial elevation of RLP-C is associated with endothelial dysfunction, an early feature of atherosclerosis, even in normolipidemic subjects. 46 The present results suggest that both fasting hypertriglyceridemia and normotriglyceridemia with PPL are associated with the predominance of sd-LDLs, potent proatherogenic lipoproteins. Future studies should focus on the role of PPL in future CHD events.…”

Section: Circulation Journal Vol68 December 2004mentioning

confidence: 50%

Association Between Small Dense Low-Density Lipoprotein and Postprandial Accumulation of Triglyceride-Rich Remnant-Like Particles in Normotriglyceridemic Patients With Myocardial Infarction

Tsunoda

Koba

Hirano

et al. 2004

Circ J

View full text Add to dashboard Cite

“…Elevated postprandial plasma triglycerides are an established risk factor for cardiovascular disease [63] and several reports have indicated that increased postprandial hypertriglyceridemia can impair endothelial function in normolipidaemic subjects [64,65]. Because cells can respond to whole-body changes by releasing circulating microparticles that are able to carry a biological message, microparticles can represent an early response to injury and may predict future adverse events in population at risk.…”

Section: Dyslipidaemiasmentioning

confidence: 99%