Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Agouni, Abdelali; Andriantsitohaina, Ramaroson; Martinez, Maria Carmen

doi:10.2174/1570161112666140423223148

Cited by 41 publications

(40 citation statements)

References 81 publications

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“…Apoptotic bodies are small-sized vesicles of <1.0 μm carrying fragmented chromosomal DNA (19), thus appearing positive after DAPI staining, and absent in non-apoptotic cells. Since the resolution of commercially available fluorescent microscopy systems enables the detection of apoptotic bodies, we raised the question of whether this type of apoptotic marker may also be suitable for detection of apoptotic events.…”

Section: (***) As Determined By the Student's T-test C D: Chromatinmentioning

confidence: 99%

Detection and Quantification of Nuclear Morphology Changes in Apoptotic Cells by Fluorescence Microscopy and Subsequent Analysis of Visualized Fluorescent Signals

Mandelkow¹,

Gümbel²,

Ahrend³

et al. 2017

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Section: (***) As Determined By the Student's T-test C D: Chromatinmentioning

confidence: 99%

Detection and Quantification of Nuclear Morphology Changes in Apoptotic Cells by Fluorescence Microscopy and Subsequent Analysis of Visualized Fluorescent Signals

Mandelkow¹,

Gümbel²,

Ahrend³

et al. 2017

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“…В какой-то степени охаракте-ризованы ВВ синовиальной жидкости и слюны [21], мочи [22], межклеточной жидкости печени [23], мозга [20], плаценты [24], внеклеточного матрикса [25] и особенно органического матрикса скелетных тканей [26]. Разумеется, наиболее детально изученными яв-ляются ВВ плазмы крови.…”

Section: Abbreviations: Dna and Rna -Deoxy-and Ribonucleic Acidsunclassified

Physiology and pathology of extracellular vesicules

Пантелеев¹,

Абаева²,

Нечипуренко³

et al. 2017

Onkogematologiâ

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ВведениеВнеклеточные везикулы (ВВ) представляют собой бислойные структуры из мембранных липидов, кото-рые присутствуют во всех жидкостях нашего организ-ма: интерстициальной, спинномозговой, амниотиче-ской и других, а также в слюне, сперме, плазме крови, лимфе. Везикулы крови были открыты самими первы-ми и остаются наиболее изученными до сих пор. Их размер варьирует в широких пределах -от десятков нанометров до микрона и более, форма чаще всего сферическая (особенно для небольших). ВВ образуют-ся при разнообразных процессах активации, жизнеде-ятельности и смерти практически из любых клеток. В зависимости от происхождения и устройства, среди ВВ выделяют экзосомы, микровезикулы, апоптотиче-ские тела и другие подтипы (впрочем, эта классифика-ция пока плохо проработана и не устоялась). В отличие от клеток, даже самых примитивных, ВВ «мертвы»: у них нет мембранной и ионной асимметрии, зависи-мых от аденозинтрифосфата (АТФ) процессов и про-чих признаков даже самых примитивных клеток. Од-нако они несут на себе и внутри себя разнообразные

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“…Additionally, apoptotic endothelial cell-derived MPs (EMPs) may directly injury an endothelial wall integrity and vascular function playing a central role in development of microvascular inflammation and IR [11]. Recent clinical studies have shown that the circulating levels of apoptotic EMPs were significantly increased in T2DM patients as compared with healthy volunteers [12] and they mediated CV risk in patients with established metabolic syndrome (MetS) and T2DM [13][14][15]. Probably apoptotic EMPs may involve in the transformation of Met-HO into Met-UHO determining the risk of T2DM and CV disease.…”

Section: Introductionmentioning

confidence: 99%

Biosensing of Circulating Apoptotic Endothelial Cell Micro particles: The Impact in Risk Stratification of Obesity

Berezin¹

2017

JABB

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Obesity is considered a main factor mediating a risk of diabetes mellitus development and a predictor of CV disease and events. Contemporary criteria of Adult Treatment Panel-III allow determining subjects with established obesity and various metabolic abnormalities, i.e. increased fasting glucose, impaired glucose tolerance dyslipidemia and insulin resistance (IR), are referred metabolically unhealthy obesity (Met-UHO), whereas individuals without these findings could be defined as those who have metabolically healthy obesity (Met-HO). The mechanisms underlying the change in phenotype from Met-HO to Met-UHO are yet not understood. It has been postulated that apoptotic endothelial cell-derived micro particles (EMPs) could be a trigger of endothelial cell dysfunction and as well as a mediator on vascular repair. Moreover, the imbalance in circulating number of various type of EMPs may influence the risk of transformation of Met-HO into Met-UHO. The short communication is depicted the role of apoptotic EMPs in obesity phenotype modification.

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Microparticles as Biomarkers of Vascular Dysfunction in Metabolic Syndrome and its Individual Components

Cited by 41 publications

References 81 publications

Detection and Quantification of Nuclear Morphology Changes in Apoptotic Cells by Fluorescence Microscopy and Subsequent Analysis of Visualized Fluorescent Signals

Detection and Quantification of Nuclear Morphology Changes in Apoptotic Cells by Fluorescence Microscopy and Subsequent Analysis of Visualized Fluorescent Signals

Physiology and pathology of extracellular vesicules

Biosensing of Circulating Apoptotic Endothelial Cell Micro particles: The Impact in Risk Stratification of Obesity

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